node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACP2 | DNAJB11 | ENSP00000256997 | ENSP00000265028 | acid phosphatase 2, lysosomal | DnaJ (Hsp40) homolog, subfamily B, member 11; Serves as a co-chaperone for HSPA5. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity | 0.644 |
ACP2 | M6PR | ENSP00000256997 | ENSP00000000412 | acid phosphatase 2, lysosomal | mannose-6-phosphate receptor (cation dependent); Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex | 0.644 |
ACP2 | NIF3L1 | ENSP00000256997 | ENSP00000386394 | acid phosphatase 2, lysosomal | NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae) | 0.644 |
ACP2 | UBC | ENSP00000256997 | ENSP00000344818 | acid phosphatase 2, lysosomal | ubiquitin C | 0.512 |
ACP2 | UQCRFS1 | ENSP00000256997 | ENSP00000306397 | acid phosphatase 2, lysosomal | ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis | 0.644 |
CBX1 | UBC | ENSP00000225603 | ENSP00000344818 | chromobox homolog 1; Component of heterochromatin. Recognizes and binds histone H3 tails methylated at ’Lys-9’, leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane | ubiquitin C | 0.869 |
DNAJB11 | ACP2 | ENSP00000265028 | ENSP00000256997 | DnaJ (Hsp40) homolog, subfamily B, member 11; Serves as a co-chaperone for HSPA5. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity | acid phosphatase 2, lysosomal | 0.644 |
DNAJB11 | UBC | ENSP00000265028 | ENSP00000344818 | DnaJ (Hsp40) homolog, subfamily B, member 11; Serves as a co-chaperone for HSPA5. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity | ubiquitin C | 0.754 |
M6PR | ACP2 | ENSP00000000412 | ENSP00000256997 | mannose-6-phosphate receptor (cation dependent); Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex | acid phosphatase 2, lysosomal | 0.644 |
NIF3L1 | ACP2 | ENSP00000386394 | ENSP00000256997 | NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae) | acid phosphatase 2, lysosomal | 0.644 |
NIF3L1 | UBC | ENSP00000386394 | ENSP00000344818 | NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae) | ubiquitin C | 0.483 |
UBC | ACP2 | ENSP00000344818 | ENSP00000256997 | ubiquitin C | acid phosphatase 2, lysosomal | 0.512 |
UBC | CBX1 | ENSP00000344818 | ENSP00000225603 | ubiquitin C | chromobox homolog 1; Component of heterochromatin. Recognizes and binds histone H3 tails methylated at ’Lys-9’, leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane | 0.869 |
UBC | DNAJB11 | ENSP00000344818 | ENSP00000265028 | ubiquitin C | DnaJ (Hsp40) homolog, subfamily B, member 11; Serves as a co-chaperone for HSPA5. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity | 0.754 |
UBC | NIF3L1 | ENSP00000344818 | ENSP00000386394 | ubiquitin C | NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae) | 0.483 |
UBC | UQCRFS1 | ENSP00000344818 | ENSP00000306397 | ubiquitin C | ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis | 0.741 |
UQCRFS1 | ACP2 | ENSP00000306397 | ENSP00000256997 | ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis | acid phosphatase 2, lysosomal | 0.644 |
UQCRFS1 | UBC | ENSP00000306397 | ENSP00000344818 | ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis | ubiquitin C | 0.741 |