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ADAMTS8 ADAMTS8 ADAMTS16 ADAMTS16 ADAMTS12 ADAMTS12 ADAMTS3 ADAMTS3 ADAMTS9 ADAMTS9 ADAMTS19 ADAMTS19 ADAMTS10 ADAMTS10 ACAN ACAN ADAMTS18 ADAMTS18 SEMA5A SEMA5A ADAMTS4 ADAMTS4 SBSPON SBSPON ADAMTS13 ADAMTS13 ADAMTS2 ADAMTS2 THSD7A THSD7A ADAMTS17 ADAMTS17 ADAMTS5 ADAMTS5 THSD7B THSD7B THBS1 THBS1 POFUT2 POFUT2 B3GALTL B3GALTL THBS2 THBS2 ADAMTSL1 ADAMTSL1 SEMA5B SEMA5B ADAMTS15 ADAMTS15 ADAMTSL5 ADAMTSL5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
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colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
ADAMTS2ADAM metallopeptidase with thrombospondin type 1 motif, 2; Cleaves the propeptides of type I and II collagen prior to fibril assembly. Does not act on type III collagen. May also play a role in development that is independent of its role in collagen biosynthesis (1211 aa)
ADAMTS8ADAM metallopeptidase with thrombospondin type 1 motif, 8; Has anti-angiogenic properties (889 aa)
THBS1thrombospondin 1; Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating antiangiogenic properties (1170 aa)
ADAMTS17ADAM metallopeptidase with thrombospondin type 1 motif, 17 (1095 aa)
ADAMTS10ADAM metallopeptidase with thrombospondin type 1 motif, 10; Metalloprotease that participate in microfibrils assembly. Microfibrils are extracellular matrix components occurring independently or along with elastin in the formation of elastic tissues (1103 aa)
THSD7Bthrombospondin, type I, domain containing 7B (1609 aa)
ADAMTS16ADAM metallopeptidase with thrombospondin type 1 motif, 16 (1224 aa)
ADAMTS19ADAM metallopeptidase with thrombospondin type 1 motif, 19 (1207 aa)
ADAMTS18ADAM metallopeptidase with thrombospondin type 1 motif, 18 (1221 aa)
ADAMTS5ADAM metallopeptidase with thrombospondin type 1 motif, 5; Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. May play a role in proteolytic processing mostly during the peri-implantation period (930 aa)
ADAMTS3ADAM metallopeptidase with thrombospondin type 1 motif, 3; Cleaves the propeptides of type II collagen prior to fibril assembly. Does not act on types I and III collagens (1205 aa)
SBSPONsomatomedin B and thrombospondin, type 1 domain containing (264 aa)
ADAMTS15ADAM metallopeptidase with thrombospondin type 1 motif, 15 (950 aa)
ADAMTSL5ADAMTS-like 5 (471 aa)
POFUT2protein O-fucosyltransferase 2; Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X(2,3)-S/T-C2-X(2)-G of thrombospondin type 1 repeats where C1 and C2 are the first and second cysteines, respectively. O-fucosylates members of several protein families including the ADAMTS family, the thrombosporin (TSP) and spondin families. The O-fucosylation of TSRs is also required for restricting epithelial to mesenchymal transition (EMT), maintaining the correct patterning of mesoderm and localization [...] (429 aa)
B3GALTLbeta 1,3-galactosyltransferase-like; O-fucosyltransferase that transfers glucose toward fucose with a beta-1,3 linkage. Specifically glucosylates O-linked fucosylglycan on TSP type-1 domains of proteins, thereby contributing to elongation of O-fucosylglycan (498 aa)
SEMA5Bsema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B; May act as positive axonal guidance cues (By similarity) (1151 aa)
THBS2thrombospondin 2; Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36 mediating antiangiogenic properties (1172 aa)
ADAMTS4ADAM metallopeptidase with thrombospondin type 1 motif, 4; Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the ’392-Glu-|-Ala-393’ site (837 aa)
ADAMTS13ADAM metallopeptidase with thrombospondin type 1 motif, 13; Cleaves the vWF multimers in plasma into smaller forms (1427 aa)
ADAMTSL1ADAMTS-like 1 (1762 aa)
SEMA5Asema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A; Bifunctional axonal guidance cue regulated by sulfated proteoglycans; attractive effects result from interactions with heparan sulfate proteoglycans (HSPGs), while the inhibitory effects depend on interactions with chondroitin sulfate proteoglycans (CSPGs) (By similarity). Ligand for receptor PLXNB3. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collaps [...] (1074 aa)
ACANaggrecan; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region (2530 aa)
THSD7Athrombospondin, type I, domain containing 7A; The soluble form promotes endothelial cell migration and filopodia formationduring angiogenesis via a FAK-dependent mechanism (1657 aa)
ADAMTS9ADAM metallopeptidase with thrombospondin type 1 motif, 9; Cleaves the large aggregating proteoglycans, aggrecan and versican (1935 aa)
ADAMTS12ADAM metallopeptidase with thrombospondin type 1 motif, 12; Metalloprotease that may play a role in the degradation of COMP. Cleaves also alpha-2 macroglobulin and aggregan. Has anti-tumorigenic properties (1594 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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