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SCARF2 SCARF2 ACTRT1 ACTRT1 ACTL7B ACTL7B SCARF1 SCARF1 CRK CRK ACTG1 ACTG1 ACTL9 ACTL9 ACTB ACTB AVIL AVIL ACTBL2 ACTBL2 POTEJ POTEJ ACTA1 ACTA1 ACTR10 ACTR10 ACTC1 ACTC1 ACTR1A ACTR1A FSCN1 FSCN1 UBC UBC ACTG2 ACTG2 ACTA2 ACTA2 ACTL8 ACTL8 FSCN3 FSCN3 POTEE POTEE ACTL7A ACTL7A FSCN2 FSCN2 POTEF POTEF POTEI POTEI
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
ACTA2actin, alpha 2, smooth muscle, aorta; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells (377 aa)
ACTR10actin-related protein 10 homolog (S. cerevisiae) (417 aa)
AVILadvillin; Ca(2+)-regulated actin-binding protein. May have a unique function in the morphogenesis of neuronal cells which form ganglia. Required for SREC1-mediated regulation of neurite-like outgrowth. Plays a role in regenerative sensory axon outgrowth and remodeling processes after peripheral injury in neonates. Involved in the formation of long fine actin-containing filopodia-like structures in fibroblast. Plays a role in ciliogenesis (819 aa)
SCARF1scavenger receptor class F, member 1; Mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). Mediates heterophilic interactions, suggesting a function as adhesion protein. Plays a role in the regulation of neurite-like outgrowth (By similarity) (830 aa)
FSCN3fascin homolog 3, actin-bundling protein, testicular (Strongylocentrotus purpuratus); Acts as an actin bundling protein (By similarity) (498 aa)
SCARF2scavenger receptor class F, member 2; Probable adhesion protein, which mediates homophilic and heterophilic interactions. In contrast to SCARF1, it poorly mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL) (By similarity) (870 aa)
ACTC1actin, alpha, cardiac muscle 1; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells (377 aa)
ACTG2actin, gamma 2, smooth muscle, enteric; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells (376 aa)
CRKv-crk sarcoma virus CT10 oncogene homolog (avian); The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk- II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling (304 aa)
ACTL9actin-like 9 (416 aa)
ACTG1actin, gamma 1; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells (375 aa)
ACTL7Aactin-like 7A (435 aa)
FSCN2fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus) (516 aa)
UBCubiquitin C (685 aa)
ACTBactin, beta (375 aa)
POTEFPOTE ankyrin domain family, member F (1075 aa)
ACTA1actin, alpha 1, skeletal muscle; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells (377 aa)
ACTR1AARP1 actin-related protein 1 homolog A, centractin alpha (yeast); Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome (376 aa)
ACTRT1actin-related protein T1 (376 aa)
ACTL7Bactin-like 7B (415 aa)
ACTL8actin-like 8 (366 aa)
FSCN1fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus); Organizes filamentous actin into bundles with a minimum of 4.1-1 actin/fascin ratio. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration (493 aa)
POTEJPOTE ankyrin domain family, member J (1038 aa)
POTEIPOTE ankyrin domain family, member I (1075 aa)
ACTBL2actin, beta-like 2; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells (By similarity) (376 aa)
POTEEPOTE ankyrin domain family member E (1075 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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