node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CIDEA | CIDEB | ENSP00000320209 | ENSP00000258807 | cell death-inducing DFFA-like effector a; Acts as a CEBPB coactivator in mammary epithelial cells to control the expression of a subset of CEBPB downstream target genes, including ID2, IGF1, PRLR, SOCS1, SOCS3, XDH, but not casein. By interacting with CEBPB, strengthens the association of CEBPB with the XDH promoter, increases histone acetylation and dissociates HDAC1 from the promoter (By similarity). Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutr [...] | cell death-inducing DFFA-like effector b; Activates apoptosis | 0.615 |
CIDEA | DFFB | ENSP00000320209 | ENSP00000367454 | cell death-inducing DFFA-like effector a; Acts as a CEBPB coactivator in mammary epithelial cells to control the expression of a subset of CEBPB downstream target genes, including ID2, IGF1, PRLR, SOCS1, SOCS3, XDH, but not casein. By interacting with CEBPB, strengthens the association of CEBPB with the XDH promoter, increases histone acetylation and dissociates HDAC1 from the promoter (By similarity). Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutr [...] | DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase); Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology | 0.938 |
CIDEB | CIDEA | ENSP00000258807 | ENSP00000320209 | cell death-inducing DFFA-like effector b; Activates apoptosis | cell death-inducing DFFA-like effector a; Acts as a CEBPB coactivator in mammary epithelial cells to control the expression of a subset of CEBPB downstream target genes, including ID2, IGF1, PRLR, SOCS1, SOCS3, XDH, but not casein. By interacting with CEBPB, strengthens the association of CEBPB with the XDH promoter, increases histone acetylation and dissociates HDAC1 from the promoter (By similarity). Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutr [...] | 0.615 |
CIDEB | DFFA | ENSP00000258807 | ENSP00000366237 | cell death-inducing DFFA-like effector b; Activates apoptosis | DNA fragmentation factor, 45kDa, alpha polypeptide; Inhibitor of the caspase-activated DNase (DFF40) | 0.940 |
CIDEB | DFFB | ENSP00000258807 | ENSP00000367454 | cell death-inducing DFFA-like effector b; Activates apoptosis | DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase); Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology | 0.892 |
CIDEB | HM13 | ENSP00000258807 | ENSP00000381237 | cell death-inducing DFFA-like effector b; Activates apoptosis | histocompatibility (minor) 13 | 0.576 |
DFFA | CIDEB | ENSP00000366237 | ENSP00000258807 | DNA fragmentation factor, 45kDa, alpha polypeptide; Inhibitor of the caspase-activated DNase (DFF40) | cell death-inducing DFFA-like effector b; Activates apoptosis | 0.940 |
DFFA | DFFB | ENSP00000366237 | ENSP00000367454 | DNA fragmentation factor, 45kDa, alpha polypeptide; Inhibitor of the caspase-activated DNase (DFF40) | DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase); Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology | 0.999 |
DFFA | HM13 | ENSP00000366237 | ENSP00000381237 | DNA fragmentation factor, 45kDa, alpha polypeptide; Inhibitor of the caspase-activated DNase (DFF40) | histocompatibility (minor) 13 | 0.615 |
DFFB | CIDEA | ENSP00000367454 | ENSP00000320209 | DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase); Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology | cell death-inducing DFFA-like effector a; Acts as a CEBPB coactivator in mammary epithelial cells to control the expression of a subset of CEBPB downstream target genes, including ID2, IGF1, PRLR, SOCS1, SOCS3, XDH, but not casein. By interacting with CEBPB, strengthens the association of CEBPB with the XDH promoter, increases histone acetylation and dissociates HDAC1 from the promoter (By similarity). Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutr [...] | 0.938 |
DFFB | CIDEB | ENSP00000367454 | ENSP00000258807 | DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase); Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology | cell death-inducing DFFA-like effector b; Activates apoptosis | 0.892 |
DFFB | DFFA | ENSP00000367454 | ENSP00000366237 | DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase); Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology | DNA fragmentation factor, 45kDa, alpha polypeptide; Inhibitor of the caspase-activated DNase (DFF40) | 0.999 |
DFFB | HM13 | ENSP00000367454 | ENSP00000381237 | DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase); Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology | histocompatibility (minor) 13 | 0.985 |
HM13 | CIDEB | ENSP00000381237 | ENSP00000258807 | histocompatibility (minor) 13 | cell death-inducing DFFA-like effector b; Activates apoptosis | 0.576 |
HM13 | DFFA | ENSP00000381237 | ENSP00000366237 | histocompatibility (minor) 13 | DNA fragmentation factor, 45kDa, alpha polypeptide; Inhibitor of the caspase-activated DNase (DFF40) | 0.615 |
HM13 | DFFB | ENSP00000381237 | ENSP00000367454 | histocompatibility (minor) 13 | DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase); Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology | 0.985 |