node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
COA3 | TACO1 | ENSP00000354762 | ENSP00000258975 | cytochrome c oxidase assembly factor 3; Component of some MITRAC complex, a cytochrome c oxidase (COX) assembly intermediate complex that regulates COX assembly. MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion. Required for efficient translation of MT-CO1 and mitochondrial respiratory chain complex IV assembly | translational activator of mitochondrially encoded cytochrome c oxidase I; Acts as a translational activator of mitochondrially- encoded cytochrome c oxidase 1 | 0.805 |
COA3 | UBC | ENSP00000354762 | ENSP00000344818 | cytochrome c oxidase assembly factor 3; Component of some MITRAC complex, a cytochrome c oxidase (COX) assembly intermediate complex that regulates COX assembly. MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion. Required for efficient translation of MT-CO1 and mitochondrial respiratory chain complex IV assembly | ubiquitin C | 0.483 |
HPDL | TACO1 | ENSP00000335060 | ENSP00000258975 | 4-hydroxyphenylpyruvate dioxygenase-like; May have dioxygenase activity (Potential) | translational activator of mitochondrially encoded cytochrome c oxidase I; Acts as a translational activator of mitochondrially- encoded cytochrome c oxidase 1 | 0.644 |
ICT1 | MRPL19 | ENSP00000301585 | ENSP00000377486 | immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes | mitochondrial ribosomal protein L19 | 0.463 |
ICT1 | RARS2 | ENSP00000301585 | ENSP00000358549 | immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes | arginyl-tRNA synthetase 2, mitochondrial | 0.432 |
ICT1 | UBC | ENSP00000301585 | ENSP00000344818 | immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes | ubiquitin C | 0.532 |
MARS2 | RARS2 | ENSP00000282276 | ENSP00000358549 | methionyl-tRNA synthetase 2, mitochondrial | arginyl-tRNA synthetase 2, mitochondrial | 0.914 |
MARS2 | YARS | ENSP00000282276 | ENSP00000362576 | methionyl-tRNA synthetase 2, mitochondrial | tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction- tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) | 0.974 |
MRPL19 | ICT1 | ENSP00000377486 | ENSP00000301585 | mitochondrial ribosomal protein L19 | immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes | 0.463 |
MRPL19 | UBC | ENSP00000377486 | ENSP00000344818 | mitochondrial ribosomal protein L19 | ubiquitin C | 0.566 |
PRPF8 | SUMO2 | ENSP00000304350 | ENSP00000405965 | PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae); Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5’ and the 3’ splice site | SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae); Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduc [...] | 0.643 |
PRPF8 | TACO1 | ENSP00000304350 | ENSP00000258975 | PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae); Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5’ and the 3’ splice site | translational activator of mitochondrially encoded cytochrome c oxidase I; Acts as a translational activator of mitochondrially- encoded cytochrome c oxidase 1 | 0.789 |
PRPF8 | UBC | ENSP00000304350 | ENSP00000344818 | PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae); Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5’ and the 3’ splice site | ubiquitin C | 0.998 |
RARS2 | ICT1 | ENSP00000358549 | ENSP00000301585 | arginyl-tRNA synthetase 2, mitochondrial | immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes | 0.432 |
RARS2 | MARS2 | ENSP00000358549 | ENSP00000282276 | arginyl-tRNA synthetase 2, mitochondrial | methionyl-tRNA synthetase 2, mitochondrial | 0.914 |
RARS2 | TACO1 | ENSP00000358549 | ENSP00000258975 | arginyl-tRNA synthetase 2, mitochondrial | translational activator of mitochondrially encoded cytochrome c oxidase I; Acts as a translational activator of mitochondrially- encoded cytochrome c oxidase 1 | 0.529 |
RARS2 | UBC | ENSP00000358549 | ENSP00000344818 | arginyl-tRNA synthetase 2, mitochondrial | ubiquitin C | 0.489 |
RARS2 | YARS | ENSP00000358549 | ENSP00000362576 | arginyl-tRNA synthetase 2, mitochondrial | tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction- tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) | 0.918 |
SAT1 | TACO1 | ENSP00000368572 | ENSP00000258975 | spermidine/spermine N1-acetyltransferase 1; Enzyme which catalyzes the acetylation of polyamines. Substrate specificity- norspermidine = spermidine >> spermine > N(1)-acetylspermine > putrescine. This highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines. Also involved in the regulation of polyamine transport out of cells. Acts on 1,3-diaminopropane, 1,5-diaminopentane, putrescine, spermidine (forming N(1)- and N(8)-acetylspermidine), spermine, N(1)-acetylspermidine and N(8)-acetylspermidine | translational activator of mitochondrially encoded cytochrome c oxidase I; Acts as a translational activator of mitochondrially- encoded cytochrome c oxidase 1 | 0.441 |
SAT1 | UBC | ENSP00000368572 | ENSP00000344818 | spermidine/spermine N1-acetyltransferase 1; Enzyme which catalyzes the acetylation of polyamines. Substrate specificity- norspermidine = spermidine >> spermine > N(1)-acetylspermine > putrescine. This highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines. Also involved in the regulation of polyamine transport out of cells. Acts on 1,3-diaminopropane, 1,5-diaminopentane, putrescine, spermidine (forming N(1)- and N(8)-acetylspermidine), spermine, N(1)-acetylspermidine and N(8)-acetylspermidine | ubiquitin C | 0.660 |