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STRINGSTRING
CDO1 CDO1 BAAT BAAT STX1A STX1A ADO ADO CPLX1 CPLX1 RAB3A RAB3A GGT7 GGT7 GGT5 GGT5 GGT6 GGT6 GGT1 GGT1 SYT1 SYT1 SNAP25 SNAP25 GAD2 GAD2 SLC32A1 SLC32A1 GLS GLS RIMS1 RIMS1 GLUD2 GLUD2 DNAJC5 DNAJC5 GLUD1 GLUD1 GLUL GLUL IL4I1 IL4I1 CARNS1 CARNS1 DLD DLD CNDP2 CNDP2 CNDP1 CNDP1 UPB1 UPB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
DLDdihydrolipoamide dehydrogenase; Lipoamide dehydrogenase is a component of the glycine cleavage system as well as of the alpha-ketoacid dehydrogenase complexes. Involved in the hyperactivation of spermatazoa during capacitation and in the spermatazoal acrosome reaction (509 aa)
SLC32A1solute carrier family 32 (GABA vesicular transporter), member 1; Involved in the uptake of GABA and glycine into the synaptic vesicles (525 aa)
RAB3ARAB3A, member RAS oncogene family; Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal (220 aa)
STX1Asyntaxin 1A (brain) (288 aa)
GGT1gamma-glutamyltransferase 1; Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism. Catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors. Alternatively, glutathione can be hydrolyzed to give Cys-Gly and gamma glutamate. Isoform 3 seems to be inactive (569 aa)
CDO1cysteine dioxygenase, type I; Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range (200 aa)
SNAP25synaptosomal-associated protein, 25kDa (206 aa)
GAD2glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa); Catalyzes the production of GABA (585 aa)
BAATbile acid CoA- amino acid N-acyltransferase (glycine N-choloyltransferase); Involved in bile acid metabolism. In liver hepatocytes catalyzes the second step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi. The major components of bile are cholic acid and chenodeoxycholic acid. In a first step the bile acids are converted to an acyl-CoA thioester, either in peroxisomes (primary bile acids deriving from the cholesterol pathway), or cytoplasmic at the endoplasmic reticulum (secondary bile acids). May catalyze the conjugation [...] (418 aa)
SYT1synaptotagmin I; May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2 (422 aa)
GLUD1glutamate dehydrogenase 1; May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (By similarity) (558 aa)
CPLX1complexin 1; Positively regulates a late step in synaptic vesicle exocytosis. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells (By similarity) (134 aa)
GLULglutamate-ammonia ligase; This enzyme has 2 functions- it catalyzes the production of glutamine and 4-aminobutanoate (gamma-aminobutyric acid, GABA), the latter in a pyridoxal phosphate-independent manner (By similarity). Essential for proliferation of fetal skin fibroblasts (373 aa)
GLSglutaminase; Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate in the brain. Isoform 2 lacks catalytic activity (669 aa)
UPB1ureidopropionase, beta; Converts N-carbamyl-beta-aminoisobutyric acid and N- carbamyl-beta-alanine to, respectively, beta-aminoisobutyric acid and beta-alanine, ammonia and carbon dioxide (384 aa)
CNDP2CNDP dipeptidase 2 (metallopeptidase M20 family); Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly. Isoform 2 may be play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells (475 aa)
GLUD2glutamate dehydrogenase 2; Important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission (558 aa)
GGT7gamma-glutamyltransferase 7; Cleaves glutathione conjugates (By similarity) (662 aa)
IL4I1interleukin 4 induced 1; Lysosomal L-amino-acid oxidase with highest specific activity with phenylalanine. May play a role in lysosomal antigen processing and presentation (By similarity) (589 aa)
CNDP1carnosine dipeptidase 1 (metallopeptidase M20 family) (507 aa)
DNAJC5DnaJ (Hsp40) homolog, subfamily C, member 5; May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings (By similarity) (198 aa)
ADO2-aminoethanethiol (cysteamine) dioxygenase (270 aa)
GGT5gamma-glutamyltransferase 5; Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4) (587 aa)
CARNS1carnosine synthase 1; Catalyzes the synthesis of carnosine and homocarnosine. Carnosine is synthesized more efficiently than homocarnosine (950 aa)
RIMS1regulating synaptic membrane exocytosis 1 (1692 aa)
GGT6gamma-glutamyltransferase 6; Cleaves glutathione conjugates (By similarity) (493 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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