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MRPL48 MRPL48 MRPL54 MRPL54 MRPL46 MRPL46 MRPL47 MRPL47 MRPL41 MRPL41 MRPL36 MRPL36 MRPL34 MRPL34 MRPL49 MRPL49 MRPL11 MRPL11 MRPL15 MRPL15 MRPL40 MRPL40 GFM2 GFM2 MRPL13 MRPL13 MRPL19 MRPL19 MRPL22 MRPL22 MRPL52 MRPL52 MRPL24 MRPL24 MRPL32 MRPL32 MTIF3 MTIF3 MRPL20 MRPL20 MRPL14 MRPL14 MTIF2 MTIF2 GFM1 GFM1 MRPL18 MRPL18 MRPS30 MRPS30 MRPS18B MRPS18B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
MRPL32mitochondrial ribosomal protein L32 (188 aa)
MRPL34mitochondrial ribosomal protein L34 (92 aa)
MRPS18Bmitochondrial ribosomal protein S18B (258 aa)
MRPL15mitochondrial ribosomal protein L15 (296 aa)
MTIF2mitochondrial translational initiation factor 2; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (727 aa)
MRPL49mitochondrial ribosomal protein L49 (166 aa)
GFM2G elongation factor, mitochondrial 2; Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in collaboration with MRRF. GTP hydrolysis follows the ribosome disassembly and probably occurs on the ribosome large subunit. Not involved in the GTP-dependent ribosomal translocation step during translation elongation (779 aa)
MRPL13mitochondrial ribosomal protein L13 (178 aa)
MRPL48mitochondrial ribosomal protein L48 (212 aa)
MRPL11mitochondrial ribosomal protein L11 (192 aa)
MRPL46mitochondrial ribosomal protein L46 (279 aa)
MRPL54mitochondrial ribosomal protein L54 (138 aa)
MRPL40mitochondrial ribosomal protein L40 (206 aa)
MRPL20mitochondrial ribosomal protein L20 (149 aa)
MRPL52mitochondrial ribosomal protein L52 (123 aa)
MRPL24mitochondrial ribosomal protein L24 (216 aa)
MRPL18mitochondrial ribosomal protein L18; Together with thiosulfate sulfurtransferase (TST), acts as a mitochondrial import factor for the cytosolic 5S rRNA. The precursor form shows RNA chaperone activity; is able to fold the 5S rRNA into an import-competent conformation that is recognized by rhodanese (TST). Both the cytoplasmic and mitochondrial forms are able to bind to the helix IV-loop D in the gamma domain of the 5S rRNA (180 aa)
MRPL41mitochondrial ribosomal protein L41; Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins (137 aa)
MRPL14mitochondrial ribosomal protein L14; Forms part of 2 intersubunit bridges in the assembled ribosome. Upon binding to MALSU1 intersubunit bridge formation is blocked, preventing ribosome formation and repressing translation (Probable) (145 aa)
MTIF3mitochondrial translational initiation factor 3; IF-3 binds to the 28S ribosomal subunit and shifts the equilibrum between 55S ribosomes and their 39S and 28S subunits in favor of the free subunits, thus enhancing the availability of 28S subunits on which protein synthesis initiation begins (278 aa)
MRPL36mitochondrial ribosomal protein L36; Component of the large subunit of the mitochondrial ribosome (Potential) (103 aa)
MRPL19mitochondrial ribosomal protein L19 (292 aa)
MRPL47mitochondrial ribosomal protein L47 (250 aa)
GFM1G elongation factor, mitochondrial 1; Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A- site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of m [...] (751 aa)
MRPS30mitochondrial ribosomal protein S30 (439 aa)
MRPL22mitochondrial ribosomal protein L22 (206 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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