node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FDXACB1 | PRELID1 | ENSP00000260257 | ENSP00000302114 | ferredoxin-fold anticodon binding domain containing 1 | PRELI domain containing 1; May be important for the development of vital and immunocompetent organs | 0.729 |
FDXACB1 | RBMXL2 | ENSP00000260257 | ENSP00000304139 | ferredoxin-fold anticodon binding domain containing 1 | RNA binding motif protein, X-linked-like 2 | 0.644 |
FDXACB1 | TRIAP1 | ENSP00000260257 | ENSP00000449795 | ferredoxin-fold anticodon binding domain containing 1 | TP53 regulated inhibitor of apoptosis 1; Mediates cell survival by inhibiting activation of caspase-9 which prevents induction of apoptosis | 0.661 |
FDXACB1 | YARS | ENSP00000260257 | ENSP00000362576 | ferredoxin-fold anticodon binding domain containing 1 | tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction- tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) | 0.611 |
HSPD1 | YARS | ENSP00000340019 | ENSP00000362576 | heat shock 60kDa protein 1 (chaperonin); Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix | tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction- tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) | 0.725 |
HSPD1 | YME1L1 | ENSP00000340019 | ENSP00000318480 | heat shock 60kDa protein 1 (chaperonin); Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix | YME1-like 1 (S. cerevisiae); Putative ATP-dependent protease which plays a role in mitochondrial protein metabolism. Ensures cell proliferation, maintains normal cristae morphology and complex I respiration activity, promotes antiapoptotic activity and protects mitochondria from the accumulation of oxidatively damaged membrane proteins. Requires to control the accumulation of nonassembled respiratory chain subunits (NDUFB6, OX4 and ND1). Seems to act in the processing of OPA1 | 0.758 |
PITRM1 | YME1L1 | ENSP00000370377 | ENSP00000318480 | pitrilysin metallopeptidase 1 | YME1-like 1 (S. cerevisiae); Putative ATP-dependent protease which plays a role in mitochondrial protein metabolism. Ensures cell proliferation, maintains normal cristae morphology and complex I respiration activity, promotes antiapoptotic activity and protects mitochondria from the accumulation of oxidatively damaged membrane proteins. Requires to control the accumulation of nonassembled respiratory chain subunits (NDUFB6, OX4 and ND1). Seems to act in the processing of OPA1 | 0.602 |
PPP2CA | PPP2CB | ENSP00000418447 | ENSP00000221138 | protein phosphatase 2, catalytic subunit, alpha isozyme; PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at ’Ser-259’ | protein phosphatase 2, catalytic subunit, beta isozyme; PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase | 0.900 |
PPP2CB | PPP2CA | ENSP00000221138 | ENSP00000418447 | protein phosphatase 2, catalytic subunit, beta isozyme; PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase | protein phosphatase 2, catalytic subunit, alpha isozyme; PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at ’Ser-259’ | 0.900 |
PRELID1 | FDXACB1 | ENSP00000302114 | ENSP00000260257 | PRELI domain containing 1; May be important for the development of vital and immunocompetent organs | ferredoxin-fold anticodon binding domain containing 1 | 0.729 |
PRELID1 | TRIAP1 | ENSP00000302114 | ENSP00000449795 | PRELI domain containing 1; May be important for the development of vital and immunocompetent organs | TP53 regulated inhibitor of apoptosis 1; Mediates cell survival by inhibiting activation of caspase-9 which prevents induction of apoptosis | 0.967 |
RBMXL2 | FDXACB1 | ENSP00000304139 | ENSP00000260257 | RNA binding motif protein, X-linked-like 2 | ferredoxin-fold anticodon binding domain containing 1 | 0.644 |
TOMM20 | TOMM22 | ENSP00000355566 | ENSP00000216034 | translocase of outer mitochondrial membrane 20 homolog (yeast); Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity) | translocase of outer mitochondrial membrane 22 homolog (yeast); Central receptor component of the translocase of the outer membrane of mitochondria (TOM complex) responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with the peripheral receptor TOM20 functions as the transit peptide receptor and facilitates the movement of preproteins into the translocation pore | 0.999 |
TOMM20L | TOMM22 | ENSP00000354204 | ENSP00000216034 | translocase of outer mitochondrial membrane 20 homolog (yeast)-like | translocase of outer mitochondrial membrane 22 homolog (yeast); Central receptor component of the translocase of the outer membrane of mitochondria (TOM complex) responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with the peripheral receptor TOM20 functions as the transit peptide receptor and facilitates the movement of preproteins into the translocation pore | 0.947 |
TOMM22 | TOMM20 | ENSP00000216034 | ENSP00000355566 | translocase of outer mitochondrial membrane 22 homolog (yeast); Central receptor component of the translocase of the outer membrane of mitochondria (TOM complex) responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with the peripheral receptor TOM20 functions as the transit peptide receptor and facilitates the movement of preproteins into the translocation pore | translocase of outer mitochondrial membrane 20 homolog (yeast); Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity) | 0.999 |
TOMM22 | TOMM20L | ENSP00000216034 | ENSP00000354204 | translocase of outer mitochondrial membrane 22 homolog (yeast); Central receptor component of the translocase of the outer membrane of mitochondria (TOM complex) responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with the peripheral receptor TOM20 functions as the transit peptide receptor and facilitates the movement of preproteins into the translocation pore | translocase of outer mitochondrial membrane 20 homolog (yeast)-like | 0.947 |
TRIAP1 | FDXACB1 | ENSP00000449795 | ENSP00000260257 | TP53 regulated inhibitor of apoptosis 1; Mediates cell survival by inhibiting activation of caspase-9 which prevents induction of apoptosis | ferredoxin-fold anticodon binding domain containing 1 | 0.661 |
TRIAP1 | PRELID1 | ENSP00000449795 | ENSP00000302114 | TP53 regulated inhibitor of apoptosis 1; Mediates cell survival by inhibiting activation of caspase-9 which prevents induction of apoptosis | PRELI domain containing 1; May be important for the development of vital and immunocompetent organs | 0.967 |
TRIAP1 | YME1L1 | ENSP00000449795 | ENSP00000318480 | TP53 regulated inhibitor of apoptosis 1; Mediates cell survival by inhibiting activation of caspase-9 which prevents induction of apoptosis | YME1-like 1 (S. cerevisiae); Putative ATP-dependent protease which plays a role in mitochondrial protein metabolism. Ensures cell proliferation, maintains normal cristae morphology and complex I respiration activity, promotes antiapoptotic activity and protects mitochondria from the accumulation of oxidatively damaged membrane proteins. Requires to control the accumulation of nonassembled respiratory chain subunits (NDUFB6, OX4 and ND1). Seems to act in the processing of OPA1 | 0.569 |
YARS | FDXACB1 | ENSP00000362576 | ENSP00000260257 | tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction- tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) | ferredoxin-fold anticodon binding domain containing 1 | 0.611 |