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CCBL2 CCBL2 GPT2 GPT2 CCBL1 CCBL1 GPT GPT ACCSL ACCSL ACCS ACCS ALDH18A1 ALDH18A1 TAT TAT RFPL3 RFPL3 ASNSD1 ASNSD1 MPP7 MPP7 MPP6 MPP6 MPP2 MPP2 DLG3 DLG3 DLG1 DLG1 GUK1 GUK1 IMPDH2 IMPDH2 DLG2 DLG2 MPP1 MPP1 CASK CASK MPP3 MPP3 CARD10 CARD10 MPP5 MPP5 CARD14 CARD14 LRGUK LRGUK MPP4 MPP4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
MPP6membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6) (540 aa)
RFPL3ret finger protein-like 3 (317 aa)
CARD10caspase recruitment domain family, member 10; Activates NF-kappa-B via BCL10 and IKK (1032 aa)
CCBL2cysteine conjugate-beta lyase 2 (454 aa)
ASNSD1asparagine synthetase domain containing 1 (643 aa)
MPP5membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5); May play a role in tight junctions biogenesis and in the establishment of cell polarity in epithelial cells. May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter. Required for localization of EZR to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton (By similarity) (675 aa)
ACCS1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional); Does not catalyze the synthesis of 1-aminocyclopropane- 1-carboxylate but is capable of catalyzing the deamination of L- vinylglycine (501 aa)
MPP2membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) (552 aa)
LRGUKleucine-rich repeats and guanylate kinase domain containing (825 aa)
CCBL1cysteine conjugate-beta lyase, cytoplasmic; Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites. Catalyzes the beta- elimination of S-conjugates and Se-conjugates of L- (seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond (422 aa)
IMPDH2IMP (inosine 5’-monophosphate) dehydrogenase 2; Catalyzes the conversion of inosine 5’-phosphate (IMP) to xanthosine 5’-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors (514 aa)
MPP7membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7); Acts as an important adapter that promotes epithelial cell polarity and tight junction formation via its interaction with DLG1. Involved in the assembly of protein complexes at sites of cell-cell contact (576 aa)
CARD14caspase recruitment domain family, member 14; Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10 (1004 aa)
GPT2glutamic pyruvate transaminase (alanine aminotransferase) 2; Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate (523 aa)
DLG1discs, large homolog 1 (Drosophila) (926 aa)
TATtyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity towards phenylalanine (454 aa)
GUK1guanylate kinase 1; Essential for recycling GMP and indirectly, cGMP (241 aa)
MPP1membrane protein, palmitoylated 1, 55kDa; Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity (By similarity) (466 aa)
ALDH18A1aldehyde dehydrogenase 18 family, member A1 (795 aa)
DLG3discs, large homolog 3 (Drosophila); Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling (817 aa)
DLG2discs, large homolog 2 (Drosophila); Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses (By similarity) (975 aa)
CASKcalcium/calmodulin-dependent serine protein kinase (MAGUK family) (921 aa)
ACCSL1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional)-like (568 aa)
GPTglutamic-pyruvate transaminase (alanine aminotransferase); Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles (By similarity) (496 aa)
MPP3membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3) (585 aa)
MPP4membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4); May play a role in retinal photoreceptors development (By similarity) (637 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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