node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALKBH8 | ENSG00000268412 | ENSP00000374219 | ENSP00000472299 | alkB, alkylation repair homolog 8 (E. coli); Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA. Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA. Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys). Required for normal survival after DNA damage. May inhibit apoptosis and promote cell survival and angiogenesis | Uncharacterized protein | 0.936 |
ALKBH8 | TRMT112 | ENSP00000374219 | ENSP00000438349 | alkB, alkylation repair homolog 8 (E. coli); Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA. Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA. Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys). Required for normal survival after DNA damage. May inhibit apoptosis and promote cell survival and angiogenesis | tRNA methyltransferase 11-2 homolog (S. cerevisiae); Participates both in methylation of protein and tRNA species. The heterodimer with HEMK2/N6AMT1 catalyzes N5- methylation of ETF1 on ’Gln-185’, using S-adenosyl L-methionine as methyl donor. The heterodimer with ALKBH8 catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA species | 0.972 |
ALKBH8 | TRMT5 | ENSP00000374219 | ENSP00000261249 | alkB, alkylation repair homolog 8 (E. coli); Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA. Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA. Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys). Required for normal survival after DNA damage. May inhibit apoptosis and promote cell survival and angiogenesis | tRNA methyltransferase 5 homolog (S. cerevisiae); Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5’ of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding | 0.617 |
EEF1A1 | ETF1 | ENSP00000330054 | ENSP00000353741 | eukaryotic translation elongation factor 1 alpha 1; This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production | eukaryotic translation termination factor 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons | 0.868 |
ENSG00000267168 | ENSG00000268412 | ENSP00000466829 | ENSP00000472299 | Uncharacterized protein | Uncharacterized protein | 0.428 |
ENSG00000267168 | TRMT112 | ENSP00000466829 | ENSP00000438349 | Uncharacterized protein | tRNA methyltransferase 11-2 homolog (S. cerevisiae); Participates both in methylation of protein and tRNA species. The heterodimer with HEMK2/N6AMT1 catalyzes N5- methylation of ETF1 on ’Gln-185’, using S-adenosyl L-methionine as methyl donor. The heterodimer with ALKBH8 catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA species | 0.428 |
ENSG00000268412 | ALKBH8 | ENSP00000472299 | ENSP00000374219 | Uncharacterized protein | alkB, alkylation repair homolog 8 (E. coli); Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA. Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA. Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys). Required for normal survival after DNA damage. May inhibit apoptosis and promote cell survival and angiogenesis | 0.936 |
ENSG00000268412 | ENSG00000267168 | ENSP00000472299 | ENSP00000466829 | Uncharacterized protein | Uncharacterized protein | 0.428 |
ENSG00000268412 | FAM173A | ENSP00000472299 | ENSP00000454380 | Uncharacterized protein | family with sequence similarity 173, member A | 0.428 |
ENSG00000268412 | KIAA1456 | ENSP00000472299 | ENSP00000432695 | Uncharacterized protein | KIAA1456 | 0.881 |
ENSG00000268412 | METTL21C | ENSP00000472299 | ENSP00000267273 | Uncharacterized protein | methyltransferase like 21C; Protein-lysine methyltransferase | 0.428 |
ENSG00000268412 | NDUFAF5 | ENSP00000472299 | ENSP00000367346 | Uncharacterized protein | NADH dehydrogenase (ubiquinone) complex I, assembly factor 5; Involved in the assembly of mitochondrial NADH-ubiquinone oxidoreductase complex (complex I, MT-ND1) at early stages. May have methyltransferase activity | 0.428 |
ENSG00000268412 | PRMT7 | ENSP00000472299 | ENSP00000343103 | Uncharacterized protein | protein arginine methyltransferase 7; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 ’Arg-3’ to form H4R3me2s. Plays a role in gene imprinting by being r [...] | 0.428 |
ENSG00000268412 | TRMT5 | ENSP00000472299 | ENSP00000261249 | Uncharacterized protein | tRNA methyltransferase 5 homolog (S. cerevisiae); Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5’ of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding | 0.476 |
ENSG00000268412 | WBSCR22 | ENSP00000472299 | ENSP00000401191 | Uncharacterized protein | Williams Beuren syndrome chromosome region 22 | 0.814 |
ENSG00000268412 | WBSCR27 | ENSP00000472299 | ENSP00000297873 | Uncharacterized protein | Williams Beuren syndrome chromosome region 27 | 0.801 |
ETF1 | EEF1A1 | ENSP00000353741 | ENSP00000330054 | eukaryotic translation termination factor 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons | eukaryotic translation elongation factor 1 alpha 1; This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production | 0.868 |
ETF1 | TRMT112 | ENSP00000353741 | ENSP00000438349 | eukaryotic translation termination factor 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons | tRNA methyltransferase 11-2 homolog (S. cerevisiae); Participates both in methylation of protein and tRNA species. The heterodimer with HEMK2/N6AMT1 catalyzes N5- methylation of ETF1 on ’Gln-185’, using S-adenosyl L-methionine as methyl donor. The heterodimer with ALKBH8 catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA species | 0.403 |
FAM173A | ENSG00000268412 | ENSP00000454380 | ENSP00000472299 | family with sequence similarity 173, member A | Uncharacterized protein | 0.428 |
FAM173A | TRMT112 | ENSP00000454380 | ENSP00000438349 | family with sequence similarity 173, member A | tRNA methyltransferase 11-2 homolog (S. cerevisiae); Participates both in methylation of protein and tRNA species. The heterodimer with HEMK2/N6AMT1 catalyzes N5- methylation of ETF1 on ’Gln-185’, using S-adenosyl L-methionine as methyl donor. The heterodimer with ALKBH8 catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA species | 0.428 |