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STRINGSTRING
ZC3H3 ZC3H3 CPSF4L CPSF4L ZC3H8 ZC3H8 ZC3H6 ZC3H6 CPSF4 CPSF4 ZC3H4 ZC3H4 PAPOLB PAPOLB PAPOLG PAPOLG CSTF2 CSTF2 PCF11 PCF11 CSTF2T CSTF2T ACOX2 ACOX2 FIP1L1 FIP1L1 PAPOLA PAPOLA MKRN2 MKRN2 COG4 COG4 CLP1 CLP1 YTHDC1 YTHDC1 UBC UBC SGSM3 SGSM3 YTHDC2 YTHDC2 PPWD1 PPWD1 ACOX3 ACOX3 EIF2B5 EIF2B5 CDC45 CDC45 EED EED
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
YTHDC2YTH domain containing 2 (1430 aa)
MKRN2makorin ring finger protein 2; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (By similarity) (416 aa)
PAPOLApoly(A) polymerase alpha; Polymerase that creates the 3’-poly(A) tail of mRNA’s. Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. May acquire specificity through interaction with a cleavage and polyadenylation specificity factor (CPSF) at its C-terminus (745 aa)
PAPOLGpoly(A) polymerase gamma; Responsible for the post-transcriptional adenylation of the 3’-terminal of mRNA precursors and several small RNAs including signal recognition particle (SRP) RNA, nuclear 7SK RNA, U2 small nuclear RNA, and ribosomal 5S RNA (736 aa)
SGSM3small G protein signaling modulator 3; May play a cooperative role in NF2-mediated growth suppression of cells (749 aa)
ZC3H4zinc finger CCCH-type containing 4 (1303 aa)
PPWD1peptidylprolyl isomerase domain and WD repeat containing 1; Putative peptidylprolyl isomerase (PPIase). PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved in pre-mRNA splicing (646 aa)
ZC3H3zinc finger CCCH-type containing 3 (948 aa)
EEDembryonic ectoderm development; Polycomb group (PcG) protein. Component of the PRC2/EED- EZH2 complex, which methylates ’Lys-9’ and ’Lys-27’ of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes ’Lys-26’ trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 ’Lys-27’, whereas H3 ’Lys-27’ recognition has the opposite effect, enabling the propagation of this repressive mark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby link [...] (441 aa)
EIF2B5eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa; Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP (721 aa)
CPSF4cleavage and polyadenylation specific factor 4, 30kDa; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3’-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U) (269 aa)
PCF11PCF11, cleavage and polyadenylation factor subunit, homolog (S. cerevisiae); Component of pre-mRNA cleavage complex II (1555 aa)
ACOX2acyl-CoA oxidase 2, branched chain; Oxidizes the CoA esters of the bile acid intermediates di- and tri-hydroxycholestanoic acids (681 aa)
COG4component of oligomeric golgi complex 4; Required for normal Golgi function. Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1 (789 aa)
CSTF2Tcleavage stimulation factor, 3’ pre-RNA, subunit 2, 64kDa, tau variant; May play a significant role in AAUAAA-independent mRNA polyadenylation in germ cells. Directly involved in the binding to pre-mRNAs (By similarity) (616 aa)
FIP1L1FIP1 like 1 (S. cerevisiae) (594 aa)
YTHDC1YTH domain containing 1; May be part of a signal transduction pathway that influences splice site selection (By similarity) (727 aa)
CPSF4Lcleavage and polyadenylation specific factor 4-like (179 aa)
UBCubiquitin C (685 aa)
ACOX3acyl-CoA oxidase 3, pristanoyl; Oxidizes the CoA-esters of 2-methyl-branched fatty acids (By similarity) (700 aa)
CSTF2cleavage stimulation factor, 3’ pre-RNA, subunit 2, 64kDa; One of the multiple factors required for polyadenylation and 3’-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs (By similarity) (577 aa)
PAPOLBpoly(A) polymerase beta (testis specific) (636 aa)
ZC3H8zinc finger CCCH-type containing 8; Acts as a transcriptional repressor of the GATA3 promoter. Sequence-specific DNA-binding factor that binds to the 5’-AGGTCTC-3’ sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene (By similarity). Induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis (291 aa)
ZC3H6zinc finger CCCH-type containing 6 (1189 aa)
CDC45cell division cycle 45 homolog (S. cerevisiae); Required for initiation of chromosomal DNA replication (598 aa)
CLP1cleavage and polyadenylation factor I subunit 1; Polynucleotide kinase that can phosphorylate the 5’- hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA-RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA-RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3’-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5’-terminus of the tRNA 3’-exon during tRNA splicin [...] (425 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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