Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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 | DOPEY1 | dopey family member 1; May be involved in protein traffic between late Golgi and early endosomes (By similarity) (2465 aa) | ||
 | ARFIP2 | ADP-ribosylation factor interacting protein 2; Putative target protein of ADP-ribosylation factor. Involved in membrane ruffling (341 aa) | ||
 | ARL1 | ADP-ribosylation factor-like 1; GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus (181 aa) | ||
 | RAB36 | RAB36, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) (333 aa) | ||
 | RAB41 | RAB41, member RAS oncogene family (221 aa) | ||
 | RAB6B | RAB6B, member RAS oncogene family; Seems to have a role in retrograde membrane traffic at the level of the Golgi complex. May function in retrograde transport in neuronal cells (208 aa) | ||
 | GCC2 | GRIP and coiled-coil domain containing 2; Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi-associated microtubules through recruitment of CLASP1 and CLASP2 (1684 aa) | ||
 | RAB6A | RAB6A, member RAS oncogene family; Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity (208 aa) | ||
 | ARFGAP1 | ADP-ribosylation factor GTPase activating protein 1 (414 aa) | ||
 | TBC1D22A | TBC1 domain family, member 22A (517 aa) | ||
 | ATP9A | ATPase, class II, type 9A (1047 aa) | ||
 | ACACA | acetyl-CoA carboxylase alpha (2383 aa) | ||
 | UBC | ubiquitin C (685 aa) | ||
 | GOLGA4 | golgin A4; May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1 (2243 aa) | ||
 | BECN1 | beclin 1, autophagy related; Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus (450 aa) | ||
 | STX16 | syntaxin 16 (325 aa) | ||
 | TBC1D22B | TBC1 domain family, member 22B; May act as a GTPase-activating protein for Rab family protein(s) (By similarity) (505 aa) | ||
 | MON2 | MON2 homolog (S. cerevisiae); May be required for traffic between late Golgi and early endosomes (By similarity) (1717 aa) | ||
 | DOPEY2 | dopey family member 2; May be involved in protein traffic between late Golgi and early endosomes (By similarity) (2298 aa) | ||
 | RAB6C | RAB6C, member RAS oncogene family; May be involved in the regulation of centrosome duplication and cell cycle progression (254 aa) | ||
 | TMCO3 | transmembrane and coiled-coil domains 3; Probable Na(+)/H(+) antiporter (By similarity) (677 aa) | ||
 | COG6 | component of oligomeric golgi complex 6; Required for normal Golgi function (By similarity) (657 aa) | ||
 | ATP9B | ATPase, class II, type 9B (1147 aa) | ||
 | RAB34 | RAB34, member RAS oncogene family; Protein transport. Involved in the redistribution of lysosomes to the peri-Golgi region (By similarity). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes (316 aa) | ||
 | KIAA1432 | KIAA1432 (1423 aa) | ||
 | ENSG00000254995 | STX16-NPEPL1 readthrough (non-protein coding) (382 aa) | ||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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