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SLC11A2 SLC11A2 FECH FECH COA6 COA6 COX6B2 COX6B2 HCCS HCCS MT-CO1 MT-CO1 COX10 COX10 SLC11A1 SLC11A1 COX15 COX15 COX6B1 COX6B1 COX11 COX11 SURF1 SURF1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
COX15cytochrome c oxidase assembly homolog 15 (yeast); May be involved in the biosynthesis of heme A (410 aa)
SLC11A1solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1; Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the catio [...] (550 aa)
COX6B1cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous); Connects the two COX monomers into the physiological dimeric form (By similarity) (86 aa)
COX10cytochrome c oxidase assembly homolog 10 (yeast); Converts protoheme IX and farnesyl diphosphate to heme O (By similarity) (443 aa)
COX11cytochrome c oxidase assembly homolog 11 (yeast); Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity) (276 aa)
COX6B2cytochrome c oxidase subunit VIb polypeptide 2 (testis); Connects the two COX monomers into the physiological dimeric form (By similarity) (88 aa)
HCCSholocytochrome c synthase; Links covalently the heme group to the apoprotein of cytochrome c (By similarity) (268 aa)
MT-CO1mitochondrially encoded cytochrome c oxidase I; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B (By similarity) (513 aa)
COA6cytochrome c oxidase assembly factor 6 homolog (S. cerevisiae) (125 aa)
SURF1surfeit 1; Probably involved in the biogenesis of the COX complex (300 aa)
FECHferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) (429 aa)
SLC11A2solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 (590 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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