node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CACNA1A | CACNA1C | ENSP00000353362 | ENSP00000266376 | calcium channel, voltage-dependent, P/Q type, alpha 1A subunit | calcium channel, voltage-dependent, L type, alpha 1C subunit | 0.493 |
CACNA1A | CACNA1D | ENSP00000353362 | ENSP00000288139 | calcium channel, voltage-dependent, P/Q type, alpha 1A subunit | calcium channel, voltage-dependent, L type, alpha 1D subunit; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the ’high-voltage activated’ (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and b [...] | 0.481 |
CACNA1B | CACNA1C | ENSP00000360406 | ENSP00000266376 | calcium channel, voltage-dependent, N type, alpha 1B subunit; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the ’high-voltage activated’ (HVA) group and are blocked by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin- IIIA (omega-Aga-IIIA). [...] | calcium channel, voltage-dependent, L type, alpha 1C subunit | 0.781 |
CACNA1B | CACNA1D | ENSP00000360406 | ENSP00000288139 | calcium channel, voltage-dependent, N type, alpha 1B subunit; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the ’high-voltage activated’ (HVA) group and are blocked by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin- IIIA (omega-Aga-IIIA). [...] | calcium channel, voltage-dependent, L type, alpha 1D subunit; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the ’high-voltage activated’ (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and b [...] | 0.775 |
CACNA1C | CACNA1A | ENSP00000266376 | ENSP00000353362 | calcium channel, voltage-dependent, L type, alpha 1C subunit | calcium channel, voltage-dependent, P/Q type, alpha 1A subunit | 0.493 |
CACNA1C | CACNA1B | ENSP00000266376 | ENSP00000360406 | calcium channel, voltage-dependent, L type, alpha 1C subunit | calcium channel, voltage-dependent, N type, alpha 1B subunit; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the ’high-voltage activated’ (HVA) group and are blocked by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin- IIIA (omega-Aga-IIIA). [...] | 0.781 |
CACNA1C | CACNA1D | ENSP00000266376 | ENSP00000288139 | calcium channel, voltage-dependent, L type, alpha 1C subunit | calcium channel, voltage-dependent, L type, alpha 1D subunit; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the ’high-voltage activated’ (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and b [...] | 0.903 |
CACNA1D | CACNA1A | ENSP00000288139 | ENSP00000353362 | calcium channel, voltage-dependent, L type, alpha 1D subunit; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the ’high-voltage activated’ (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and b [...] | calcium channel, voltage-dependent, P/Q type, alpha 1A subunit | 0.481 |
CACNA1D | CACNA1B | ENSP00000288139 | ENSP00000360406 | calcium channel, voltage-dependent, L type, alpha 1D subunit; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the ’high-voltage activated’ (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and b [...] | calcium channel, voltage-dependent, N type, alpha 1B subunit; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the ’high-voltage activated’ (HVA) group and are blocked by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin- IIIA (omega-Aga-IIIA). [...] | 0.775 |
CACNA1D | CACNA1C | ENSP00000288139 | ENSP00000266376 | calcium channel, voltage-dependent, L type, alpha 1D subunit; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the ’high-voltage activated’ (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and b [...] | calcium channel, voltage-dependent, L type, alpha 1C subunit | 0.903 |
RIMBP2 | USP3 | ENSP00000261655 | ENSP00000369681 | RIMS binding protein 2; Plays a role in the synaptic transmission as bifunctional linker that interacts simultaneously with RIMS1, RIMS2, CACNA1D and CACNA1B (By similarity) | ubiquitin specific peptidase 3; Hydrolase that deubiquitinates monoubiquitinated target proteins such as histone H2A and H2B. Required for proper progression through S phase and subsequent mitotic entry. May regulate the DNA damage response (DDR) checkpoint through deubiquitination of H2A at DNA damage sites. Associates with the chromatin | 0.740 |
RIMBP2 | ZNF227 | ENSP00000261655 | ENSP00000321049 | RIMS binding protein 2; Plays a role in the synaptic transmission as bifunctional linker that interacts simultaneously with RIMS1, RIMS2, CACNA1D and CACNA1B (By similarity) | zinc finger protein 227; May be involved in transcriptional regulation | 0.416 |
USP3 | RIMBP2 | ENSP00000369681 | ENSP00000261655 | ubiquitin specific peptidase 3; Hydrolase that deubiquitinates monoubiquitinated target proteins such as histone H2A and H2B. Required for proper progression through S phase and subsequent mitotic entry. May regulate the DNA damage response (DDR) checkpoint through deubiquitination of H2A at DNA damage sites. Associates with the chromatin | RIMS binding protein 2; Plays a role in the synaptic transmission as bifunctional linker that interacts simultaneously with RIMS1, RIMS2, CACNA1D and CACNA1B (By similarity) | 0.740 |
ZNF227 | RIMBP2 | ENSP00000321049 | ENSP00000261655 | zinc finger protein 227; May be involved in transcriptional regulation | RIMS binding protein 2; Plays a role in the synaptic transmission as bifunctional linker that interacts simultaneously with RIMS1, RIMS2, CACNA1D and CACNA1B (By similarity) | 0.416 |