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DHTKD1 DHTKD1 AOC3 AOC3 AOC2 AOC2 SDHB SDHB MAOA MAOA COMT COMT MAOB MAOB MCEE MCEE ZADH2 ZADH2 HBB HBB CAT CAT ADH1B ADH1B SOD2 SOD2 ALDH2 ALDH2 ALDH1A2 ALDH1A2 EHHADH EHHADH ACOX2 ACOX2 ACOX1 ACOX1 HMGCL HMGCL HADHA HADHA LRTOMT LRTOMT OAT OAT CHDH CHDH TOMM20 TOMM20 DERA DERA
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small nodes:
protein of unknown 3D structure
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large nodes:
some 3D structure is known or predicted
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white nodes:
second shell of interactors
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Predicted Interactions
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EHHADHenoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase (723 aa)
CATcatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells (527 aa)
MCEEmethylmalonyl CoA epimerase (176 aa)
ALDH1A2aldehyde dehydrogenase 1 family, member A2; Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Does metabolize octanal and decanal but does not metabolize citral, benzaldehyde, acetaldehyde and propanal efficiently (By similarity) (518 aa)
AOC2amine oxidase, copper containing 2 (retina-specific); Has a monoamine oxidase activity with substrate specificity for 2-phenylethylamine and tryptamine. May play a role in adipogenesis. May be a critical modulator of signal transmission in retina (756 aa)
ALDH2aldehyde dehydrogenase 2 family (mitochondrial) (517 aa)
DHTKD1dehydrogenase E1 and transketolase domain containing 1; The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components- 2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity) (919 aa)
ACOX1acyl-CoA oxidase 1, palmitoyl (660 aa)
LRTOMTleucine rich transmembrane and 0-methyltransferase domain containing; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones (By similarity). Required for auditory function (291 aa)
ADH1Balcohol dehydrogenase 1B (class I), beta polypeptide (375 aa)
ACOX2acyl-CoA oxidase 2, branched chain; Oxidizes the CoA esters of the bile acid intermediates di- and tri-hydroxycholestanoic acids (681 aa)
AOC3amine oxidase, copper containing 3 (vascular adhesion protein 1); Cell adhesion protein that participates in lymphocyte recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin- independent fashion. Has a monoamine oxidase activity. May play a role in adipogenesis (763 aa)
CHDHcholine dehydrogenase (594 aa)
ZADH2zinc binding alcohol dehydrogenase domain containing 2 (377 aa)
HBBhemoglobin, beta (147 aa)
MAOAmonoamine oxidase A; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine (527 aa)
COMTcatechol-O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol (271 aa)
TOMM20translocase of outer mitochondrial membrane 20 homolog (yeast); Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity) (145 aa)
SOD2superoxide dismutase 2, mitochondrial; Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) (222 aa)
OATornithine aminotransferase (439 aa)
HMGCL3-hydroxymethyl-3-methylglutaryl-CoA lyase; Key enzyme in ketogenesis (ketone body formation). Terminal step in leucine catabolism (325 aa)
SDHBsuccinate dehydrogenase complex, subunit B, iron sulfur (Ip); Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (280 aa)
MAOBmonoamine oxidase B; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine (520 aa)
HADHAhydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit; Bifunctional subunit (763 aa)
DERAdeoxyribose-phosphate aldolase (putative); Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) (318 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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