node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANKRD13A | EGFR | ENSP00000261739 | ENSP00000275493 | ankyrin repeat domain 13A | epidermal growth factor receptor | 0.682 |
ANKRD13A | QDPR | ENSP00000261739 | ENSP00000281243 | ankyrin repeat domain 13A | quinoid dihydropteridine reductase; The product of this enzyme, tetrahydrobiopterin (BH-4), is an essential cofactor for phenylalanine, tyrosine, and tryptophan hydroxylases | 0.613 |
ANKRD13A | TOLLIP | ENSP00000261739 | ENSP00000314733 | ankyrin repeat domain 13A | toll interacting protein; Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity | 0.456 |
ANKRD13A | UBC | ENSP00000261739 | ENSP00000344818 | ankyrin repeat domain 13A | ubiquitin C | 0.987 |
CAV1 | EGFR | ENSP00000339191 | ENSP00000275493 | caveolin 1, caveolae protein, 22kDa; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)- mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3- dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway | epidermal growth factor receptor | 0.999 |
CAV1 | TOLLIP | ENSP00000339191 | ENSP00000314733 | caveolin 1, caveolae protein, 22kDa; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)- mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3- dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway | toll interacting protein; Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity | 0.576 |
CAV1 | UBC | ENSP00000339191 | ENSP00000344818 | caveolin 1, caveolae protein, 22kDa; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)- mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3- dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway | ubiquitin C | 0.970 |
CAV1 | VCP | ENSP00000339191 | ENSP00000351777 | caveolin 1, caveolae protein, 22kDa; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)- mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3- dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway | valosin containing protein; Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the e [...] | 0.826 |
CDK17 | UBC | ENSP00000261211 | ENSP00000344818 | cyclin-dependent kinase 17; May play a role in terminally differentiated neurons. Has a Ser/Thr-phosphorylating activity for histone H1 (By similarity) | ubiquitin C | 0.738 |
CTDSP2 | UBC | ENSP00000381148 | ENSP00000344818 | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2; Preferentially catalyzes the dephosphorylation of ’Ser- 5’ within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas | ubiquitin C | 0.656 |
EGFR | ANKRD13A | ENSP00000275493 | ENSP00000261739 | epidermal growth factor receptor | ankyrin repeat domain 13A | 0.682 |
EGFR | CAV1 | ENSP00000275493 | ENSP00000339191 | epidermal growth factor receptor | caveolin 1, caveolae protein, 22kDa; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)- mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3- dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway | 0.999 |
EGFR | UBC | ENSP00000275493 | ENSP00000344818 | epidermal growth factor receptor | ubiquitin C | 0.999 |
EGFR | VAPA | ENSP00000275493 | ENSP00000345656 | epidermal growth factor receptor | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa; May play a role in vesicle trafficking | 0.469 |
FAM189B | UBC | ENSP00000354958 | ENSP00000344818 | family with sequence similarity 189, member B | ubiquitin C | 0.483 |
FBXO25 | PSMD4 | ENSP00000276326 | ENSP00000357879 | F-box protein 25; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) (By similarity) | proteasome (prosome, macropain) 26S subunit, non-ATPase, 4; Binds and presumably selects ubiquitin-conjugates for destruction. Displays selectivity for longer polyubiquitin chains. Modulates intestinal fluid secretion | 0.514 |
PSMD4 | FBXO25 | ENSP00000357879 | ENSP00000276326 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 4; Binds and presumably selects ubiquitin-conjugates for destruction. Displays selectivity for longer polyubiquitin chains. Modulates intestinal fluid secretion | F-box protein 25; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) (By similarity) | 0.514 |
PSMD4 | UBC | ENSP00000357879 | ENSP00000344818 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 4; Binds and presumably selects ubiquitin-conjugates for destruction. Displays selectivity for longer polyubiquitin chains. Modulates intestinal fluid secretion | ubiquitin C | 0.999 |
PSMD4 | VCP | ENSP00000357879 | ENSP00000351777 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 4; Binds and presumably selects ubiquitin-conjugates for destruction. Displays selectivity for longer polyubiquitin chains. Modulates intestinal fluid secretion | valosin containing protein; Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the e [...] | 0.845 |
PSMD4 | ZFAND4 | ENSP00000357879 | ENSP00000339484 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 4; Binds and presumably selects ubiquitin-conjugates for destruction. Displays selectivity for longer polyubiquitin chains. Modulates intestinal fluid secretion | zinc finger, AN1-type domain 4 | 0.684 |