Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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 | AKR7A2 | aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase); Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2- nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcoh [...] (359 aa) | ||
 | OCM | oncomodulin; Has some calmodulin-like activity with respect to enzyme activation and growth regulation. Binds two calcium ions (109 aa) | ||
 | HCN2 | hyperpolarization activated cyclic nucleotide-gated potassium channel 2; Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Can also transport ammonium in the distal nephron. Produces a large instantaneous current. Activated by cAMP. Modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages (By similarity) (889 aa) | ||
 | HCN4 | hyperpolarization activated cyclic nucleotide-gated potassium channel 4; Hyperpolarization-activated ion channel with very slow activation and inactivation exhibiting weak selectivity for potassium over sodium ions. May contribute to the native pacemaker currents in heart (If) and in neurons (Ih). Activated by cAMP. May mediate responses to sour stimuli (1203 aa) | ||
 | KCNAB3 | potassium voltage-gated channel, shaker-related subfamily, beta member 3; Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. Alters the functional properties of Kv1.5 (404 aa) | ||
 | HCN1 | hyperpolarization activated cyclic nucleotide-gated potassium channel 1; Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Activated by cAMP, and at 10-100 times higher concentrations, also by cGMP. May mediate responses to sour stimuli (890 aa) | ||
 | CALB2 | calbindin 2; Calretinin is a calcium-binding protein which is abundant in auditory neurons (271 aa) | ||
 | CAMK2G | calcium/calmodulin-dependent protein kinase II gamma (556 aa) | ||
 | SPATA21 | spermatogenesis associated 21; Involved in the differentiation of haploid spermatids (By similarity) (469 aa) | ||
 | CAMK2D | calcium/calmodulin-dependent protein kinase II delta; Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart f [...] (499 aa) | ||
 | CAV3 | caveolin 3; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress (151 aa) | ||
 | FYN | FYN oncogene related to SRC, FGR, YES; Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motilit [...] (537 aa) | ||
 | CALM1 | calmodulin 1 (phosphorylase kinase, delta) (149 aa) | ||
 | NF1 | neurofibromin 1; Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity (2839 aa) | ||
 | AKR7A3 | aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase); Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen (By similarity) (331 aa) | ||
 | HCN3 | hyperpolarization activated cyclic nucleotide-gated potassium channel 3; Putative hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions (By similarity) (774 aa) | ||
 | ABL1 | c-abl oncogene 1, non-receptor tyrosine kinase; Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN ( [...] (1149 aa) | ||
 | KCNAB2 | potassium voltage-gated channel, shaker-related subfamily, beta member 2 (415 aa) | ||
 | CASK | calcium/calmodulin-dependent serine protein kinase (MAGUK family) (921 aa) | ||
 | CALML5 | calmodulin-like 5; Binds calcium. May be involved in terminal differentiation of keratinocytes (146 aa) | ||
 | CAMK2B | calcium/calmodulin-dependent protein kinase II beta (666 aa) | ||
 | CAMK2A | calcium/calmodulin-dependent protein kinase II alpha; CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity) (489 aa) | ||
 | EFCAB3 | EF-hand calcium binding domain 3 (490 aa) | ||
 | PEX5 | peroxisomal biogenesis factor 5; Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import (654 aa) | ||
 | KCNAB1 | potassium voltage-gated channel, shaker-related subfamily, beta member 1 (419 aa) | ||
 | PEX5L | peroxisomal biogenesis factor 5-like; Accessory subunit of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, regulating their cell-surface expression and cyclic nucleotide dependence (By similarity) (626 aa) | ||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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