node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BMP1 | LOX | ENSP00000305714 | ENSP00000231004 | bone morphogenetic protein 1 | lysyl oxidase; Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may have a direct role in tumor suppression | 0.962 |
BMP1 | LOXL1 | ENSP00000305714 | ENSP00000261921 | bone morphogenetic protein 1 | lysyl oxidase-like 1; Active on elastin and collagen substrates (By similarity) | 0.931 |
BMP1 | TLL1 | ENSP00000305714 | ENSP00000061240 | bone morphogenetic protein 1 | tolloid-like 1; Protease which processes procollagen C-propeptides, such as chordin, pro-biglycan and pro-lysyl oxidase. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis | 0.901 |
ELN | LOX | ENSP00000252034 | ENSP00000231004 | elastin | lysyl oxidase; Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may have a direct role in tumor suppression | 0.808 |
ELN | LOXL1 | ENSP00000252034 | ENSP00000261921 | elastin | lysyl oxidase-like 1; Active on elastin and collagen substrates (By similarity) | 0.576 |
ELN | MFAP2 | ENSP00000252034 | ENSP00000364685 | elastin | microfibrillar-associated protein 2; Component of the elastin-associated microfibrils | 0.576 |
FBLN5 | LOX | ENSP00000345008 | ENSP00000231004 | fibulin 5; Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Could be a vascular ligand for integrin receptors and may play a role in vascular development and remodeling | lysyl oxidase; Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may have a direct role in tumor suppression | 0.993 |
FBLN5 | LOXL1 | ENSP00000345008 | ENSP00000261921 | fibulin 5; Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Could be a vascular ligand for integrin receptors and may play a role in vascular development and remodeling | lysyl oxidase-like 1; Active on elastin and collagen substrates (By similarity) | 0.998 |
FBLN5 | MFAP2 | ENSP00000345008 | ENSP00000364685 | fibulin 5; Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Could be a vascular ligand for integrin receptors and may play a role in vascular development and remodeling | microfibrillar-associated protein 2; Component of the elastin-associated microfibrils | 0.943 |
FBLN5 | MFAP5 | ENSP00000345008 | ENSP00000352455 | fibulin 5; Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Could be a vascular ligand for integrin receptors and may play a role in vascular development and remodeling | microfibrillar associated protein 5; Component of the elastin-associated microfibrils | 0.939 |
GATAD2B | LOX | ENSP00000357644 | ENSP00000231004 | GATA zinc finger domain containing 2B; Transcriptional repressor. Enhances MBD2-mediated repression. Efficient repression requires the presence of GATAD2A. Targets MBD3 to discrete loci in the nucleus | lysyl oxidase; Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may have a direct role in tumor suppression | 0.570 |
GATAD2B | LOXL1 | ENSP00000357644 | ENSP00000261921 | GATA zinc finger domain containing 2B; Transcriptional repressor. Enhances MBD2-mediated repression. Efficient repression requires the presence of GATAD2A. Targets MBD3 to discrete loci in the nucleus | lysyl oxidase-like 1; Active on elastin and collagen substrates (By similarity) | 0.570 |
LOX | BMP1 | ENSP00000231004 | ENSP00000305714 | lysyl oxidase; Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may have a direct role in tumor suppression | bone morphogenetic protein 1 | 0.962 |
LOX | ELN | ENSP00000231004 | ENSP00000252034 | lysyl oxidase; Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may have a direct role in tumor suppression | elastin | 0.808 |
LOX | FBLN5 | ENSP00000231004 | ENSP00000345008 | lysyl oxidase; Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may have a direct role in tumor suppression | fibulin 5; Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Could be a vascular ligand for integrin receptors and may play a role in vascular development and remodeling | 0.993 |
LOX | GATAD2B | ENSP00000231004 | ENSP00000357644 | lysyl oxidase; Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may have a direct role in tumor suppression | GATA zinc finger domain containing 2B; Transcriptional repressor. Enhances MBD2-mediated repression. Efficient repression requires the presence of GATAD2A. Targets MBD3 to discrete loci in the nucleus | 0.570 |
LOX | LOXL1 | ENSP00000231004 | ENSP00000261921 | lysyl oxidase; Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may have a direct role in tumor suppression | lysyl oxidase-like 1; Active on elastin and collagen substrates (By similarity) | 0.910 |
LOX | MFAP2 | ENSP00000231004 | ENSP00000364685 | lysyl oxidase; Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may have a direct role in tumor suppression | microfibrillar-associated protein 2; Component of the elastin-associated microfibrils | 0.954 |
LOX | MFAP5 | ENSP00000231004 | ENSP00000352455 | lysyl oxidase; Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may have a direct role in tumor suppression | microfibrillar associated protein 5; Component of the elastin-associated microfibrils | 0.938 |
LOX | TLL1 | ENSP00000231004 | ENSP00000061240 | lysyl oxidase; Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may have a direct role in tumor suppression | tolloid-like 1; Protease which processes procollagen C-propeptides, such as chordin, pro-biglycan and pro-lysyl oxidase. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis | 0.948 |