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GDF15 GDF15 BMP3 BMP3 TWSG1 TWSG1 GDF6 GDF6 BMP6 BMP6 BMP1 BMP1 NODAL NODAL BMP5 BMP5 INHBC INHBC BMP8A BMP8A BMP2 BMP2 INHBB INHBB BMP4 BMP4 GDF2 GDF2 TGFB2 TGFB2 CHRD CHRD BMP8B BMP8B BMP7 BMP7 SGTA SGTA UBC UBC AMH AMH GDF9 GDF9 GDF7 GDF7 GDF1 GDF1 GDF3 GDF3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
CHRDchordin (955 aa)
AMHanti-Mullerian hormone; This glycoprotein, produced by the Sertoli cells of the testis, causes regression of the Muellerian duct. It is also able to inhibit the growth of tumors derived from tissues of Muellerian duct origin (560 aa)
SGTAsmall glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha; Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity (313 aa)
BMP4bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) (408 aa)
GDF1growth differentiation factor 1; May mediate cell differentiation events during embryonic development (372 aa)
GDF2growth differentiation factor 2 (429 aa)
GDF15growth differentiation factor 15 (308 aa)
TWSG1twisted gastrulation homolog 1 (Drosophila); May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development (By similarity) (223 aa)
GDF7growth differentiation factor 7; May play an active role in the motor area of the primate neocortex (By similarity) (450 aa)
BMP3bone morphogenetic protein 3; Negatively regulates bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification (472 aa)
BMP6bone morphogenetic protein 6; Induces cartilage and bone formation (513 aa)
GDF6growth differentiation factor 6; Required for normal formation of bones and joints in the limbs, skull, and axial skeleton. Plays a key role in establishing boundaries between skeletal elements during development (By similarity) (455 aa)
NODALnodal homolog (mouse); Essential for mesoderm formation and axial patterning during embryonic development (By similarity) (347 aa)
INHBBinhibin, beta B; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins (407 aa)
GDF9growth differentiation factor 9; Required for ovarian folliculogenesis. Promotes primordial follicle development. Stimulates granulosa cell proliferation. Promotes cell transition from G0/G1 to S and G2/M phases, through an increase of CCND1 and CCNE1 expression, and RB1 phosphorylation. It regulates STAR expression and cAMP-dependent progesterone release in granulosa and thecal cells. Attenuates the suppressive effects of activin A on STAR expression and progesterone production by increasing the expression of inhibin B. It suppresses FST and FSTL3 production in granulosa-lutein cells (454 aa)
BMP1bone morphogenetic protein 1 (986 aa)
INHBCinhibin, beta C; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins (352 aa)
BMP8Abone morphogenetic protein 8a; Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis (By similarity). Signaling protein involved in regulation of thermogenesis and energy balance. Proposed to increase the peripheral response of brown adipose tissue (BAT) to adrenergic stimulation while acting centrally in the hypothalamus to increase sympathetic output to BAT (402 aa)
GDF3growth differentiation factor 3 (364 aa)
UBCubiquitin C (685 aa)
TGFB2transforming growth factor, beta 2; TGF-beta 2 has suppressive effects on interleukin-2 dependent T-cell growth (442 aa)
BMP5bone morphogenetic protein 5; Induces cartilage and bone formation (454 aa)
BMP8Bbone morphogenetic protein 8b; Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis (By similarity) (402 aa)
BMP2bone morphogenetic protein 2; Induces cartilage and bone formation (396 aa)
BMP7bone morphogenetic protein 7; Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis (431 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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