node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACTL6B | UBC | ENSP00000160382 | ENSP00000344818 | actin-like 6B; Belongs to the chromatin remodeling brain-specific BAF (bBAF) complex, as such plays a role in remodeling mononucleosomes in an ATP-dependent fashion. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex) and is required for postmitotic neural development and dendritic outgrowth. During neural development a switch from a stem/progenitor to a post- mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons [...] | ubiquitin C | 0.687 |
ADCK1 | COQ4 | ENSP00000238561 | ENSP00000300452 | aarF domain containing kinase 1; The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr) | coenzyme Q4 homolog (S. cerevisiae); Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides | 0.486 |
ADCK1 | COQ5 | ENSP00000238561 | ENSP00000288532 | aarF domain containing kinase 1; The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr) | coenzyme Q5 homolog, methyltransferase (S. cerevisiae); Methyltransferase required for the conversion of 2- polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) | 0.716 |
ADCK1 | COQ7 | ENSP00000238561 | ENSP00000322316 | aarF domain containing kinase 1; The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr) | coenzyme Q7 homolog, ubiquinone (yeast); Involved in lifespan determination in ubiquinone- independent manner. Involved in ubiquinone biosynthesis. Potential central metabolic regulator (By similarity) | 0.417 |
ADCK1 | COQ9 | ENSP00000238561 | ENSP00000262507 | aarF domain containing kinase 1; The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr) | coenzyme Q9 homolog (S. cerevisiae); Involved in the biosynthesis of coenzyme Q (By similarity) | 0.436 |
ADCK2 | COQ4 | ENSP00000072869 | ENSP00000300452 | aarF domain containing kinase 2; The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr) | coenzyme Q4 homolog (S. cerevisiae); Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides | 0.503 |
ADCK2 | COQ5 | ENSP00000072869 | ENSP00000288532 | aarF domain containing kinase 2; The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr) | coenzyme Q5 homolog, methyltransferase (S. cerevisiae); Methyltransferase required for the conversion of 2- polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) | 0.762 |
ADCK2 | COQ7 | ENSP00000072869 | ENSP00000322316 | aarF domain containing kinase 2; The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr) | coenzyme Q7 homolog, ubiquinone (yeast); Involved in lifespan determination in ubiquinone- independent manner. Involved in ubiquinone biosynthesis. Potential central metabolic regulator (By similarity) | 0.499 |
ADCK2 | COQ9 | ENSP00000072869 | ENSP00000262507 | aarF domain containing kinase 2; The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr) | coenzyme Q9 homolog (S. cerevisiae); Involved in the biosynthesis of coenzyme Q (By similarity) | 0.436 |
ADCK3 | COQ4 | ENSP00000355739 | ENSP00000300452 | aarF domain containing kinase 3; May be a chaperone-like protein essential for the proper conformation and functioning of protein complexes in the respiratory chain | coenzyme Q4 homolog (S. cerevisiae); Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides | 0.948 |
ADCK3 | COQ5 | ENSP00000355739 | ENSP00000288532 | aarF domain containing kinase 3; May be a chaperone-like protein essential for the proper conformation and functioning of protein complexes in the respiratory chain | coenzyme Q5 homolog, methyltransferase (S. cerevisiae); Methyltransferase required for the conversion of 2- polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) | 0.967 |
ADCK3 | COQ6 | ENSP00000355739 | ENSP00000333946 | aarF domain containing kinase 3; May be a chaperone-like protein essential for the proper conformation and functioning of protein complexes in the respiratory chain | coenzyme Q6 homolog, monooxygenase (S. cerevisiae) | 0.941 |
ADCK3 | COQ7 | ENSP00000355739 | ENSP00000322316 | aarF domain containing kinase 3; May be a chaperone-like protein essential for the proper conformation and functioning of protein complexes in the respiratory chain | coenzyme Q7 homolog, ubiquinone (yeast); Involved in lifespan determination in ubiquinone- independent manner. Involved in ubiquinone biosynthesis. Potential central metabolic regulator (By similarity) | 0.935 |
ADCK3 | COQ9 | ENSP00000355739 | ENSP00000262507 | aarF domain containing kinase 3; May be a chaperone-like protein essential for the proper conformation and functioning of protein complexes in the respiratory chain | coenzyme Q9 homolog (S. cerevisiae); Involved in the biosynthesis of coenzyme Q (By similarity) | 0.984 |
ADCK3 | UBC | ENSP00000355739 | ENSP00000344818 | aarF domain containing kinase 3; May be a chaperone-like protein essential for the proper conformation and functioning of protein complexes in the respiratory chain | ubiquitin C | 0.483 |
ADCK4 | COQ4 | ENSP00000315118 | ENSP00000300452 | aarF domain containing kinase 4; The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr) | coenzyme Q4 homolog (S. cerevisiae); Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides | 0.964 |
ADCK4 | COQ5 | ENSP00000315118 | ENSP00000288532 | aarF domain containing kinase 4; The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr) | coenzyme Q5 homolog, methyltransferase (S. cerevisiae); Methyltransferase required for the conversion of 2- polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) | 0.978 |
ADCK4 | COQ6 | ENSP00000315118 | ENSP00000333946 | aarF domain containing kinase 4; The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr) | coenzyme Q6 homolog, monooxygenase (S. cerevisiae) | 0.957 |
ADCK4 | COQ7 | ENSP00000315118 | ENSP00000322316 | aarF domain containing kinase 4; The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr) | coenzyme Q7 homolog, ubiquinone (yeast); Involved in lifespan determination in ubiquinone- independent manner. Involved in ubiquinone biosynthesis. Potential central metabolic regulator (By similarity) | 0.954 |
ADCK4 | COQ9 | ENSP00000315118 | ENSP00000262507 | aarF domain containing kinase 4; The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr) | coenzyme Q9 homolog (S. cerevisiae); Involved in the biosynthesis of coenzyme Q (By similarity) | 0.981 |