node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
F7 | HPN | ENSP00000364731 | ENSP00000262626 | coagulation factor VII (serum prothrombin conversion accelerator); Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium | hepsin; Plays an essential role in cell growth and maintenance of cell morphology. May mediate the activating cleavage of HGF and MST1/HGFL | 0.665 |
HGF | HPN | ENSP00000222390 | ENSP00000262626 | hepatocyte growth factor (hepapoietin A; scatter factor) | hepsin; Plays an essential role in cell growth and maintenance of cell morphology. May mediate the activating cleavage of HGF and MST1/HGFL | 0.619 |
HGF | SPINT1 | ENSP00000222390 | ENSP00000342098 | hepatocyte growth factor (hepapoietin A; scatter factor) | serine peptidase inhibitor, Kunitz type 1; Inhibitor of HGF activator. Also acts as an inhibitor of matriptase (ST14) | 0.753 |
HPN | F7 | ENSP00000262626 | ENSP00000364731 | hepsin; Plays an essential role in cell growth and maintenance of cell morphology. May mediate the activating cleavage of HGF and MST1/HGFL | coagulation factor VII (serum prothrombin conversion accelerator); Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium | 0.665 |
HPN | HGF | ENSP00000262626 | ENSP00000222390 | hepsin; Plays an essential role in cell growth and maintenance of cell morphology. May mediate the activating cleavage of HGF and MST1/HGFL | hepatocyte growth factor (hepapoietin A; scatter factor) | 0.619 |
HPN | MASP1 | ENSP00000262626 | ENSP00000296280 | hepsin; Plays an essential role in cell growth and maintenance of cell morphology. May mediate the activating cleavage of HGF and MST1/HGFL | mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) | 0.576 |
HPN | SPINT1 | ENSP00000262626 | ENSP00000342098 | hepsin; Plays an essential role in cell growth and maintenance of cell morphology. May mediate the activating cleavage of HGF and MST1/HGFL | serine peptidase inhibitor, Kunitz type 1; Inhibitor of HGF activator. Also acts as an inhibitor of matriptase (ST14) | 0.636 |
MASP1 | HPN | ENSP00000296280 | ENSP00000262626 | mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) | hepsin; Plays an essential role in cell growth and maintenance of cell morphology. May mediate the activating cleavage of HGF and MST1/HGFL | 0.576 |
MUC2 | MUC5AC | ENSP00000415183 | ENSP00000435591 | mucin 2, oligomeric mucus/gel-forming; Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer | mucin 5AC, oligomeric mucus/gel-forming | 0.905 |
MUC2 | MUC5B | ENSP00000415183 | ENSP00000436812 | mucin 2, oligomeric mucus/gel-forming; Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer | mucin 5B, oligomeric mucus/gel-forming | 0.915 |
MUC2 | MUC6 | ENSP00000415183 | ENSP00000406861 | mucin 2, oligomeric mucus/gel-forming; Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer | mucin 6, oligomeric mucus/gel-forming; May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Plays an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial organogenesis | 0.921 |
MUC5AC | MUC2 | ENSP00000435591 | ENSP00000415183 | mucin 5AC, oligomeric mucus/gel-forming | mucin 2, oligomeric mucus/gel-forming; Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer | 0.905 |
MUC5AC | MUC5B | ENSP00000435591 | ENSP00000436812 | mucin 5AC, oligomeric mucus/gel-forming | mucin 5B, oligomeric mucus/gel-forming | 0.902 |
MUC5AC | MUC6 | ENSP00000435591 | ENSP00000406861 | mucin 5AC, oligomeric mucus/gel-forming | mucin 6, oligomeric mucus/gel-forming; May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Plays an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial organogenesis | 0.913 |
MUC5B | MUC2 | ENSP00000436812 | ENSP00000415183 | mucin 5B, oligomeric mucus/gel-forming | mucin 2, oligomeric mucus/gel-forming; Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer | 0.915 |
MUC5B | MUC5AC | ENSP00000436812 | ENSP00000435591 | mucin 5B, oligomeric mucus/gel-forming | mucin 5AC, oligomeric mucus/gel-forming | 0.902 |
MUC5B | MUC6 | ENSP00000436812 | ENSP00000406861 | mucin 5B, oligomeric mucus/gel-forming | mucin 6, oligomeric mucus/gel-forming; May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Plays an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial organogenesis | 0.920 |
MUC6 | MUC2 | ENSP00000406861 | ENSP00000415183 | mucin 6, oligomeric mucus/gel-forming; May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Plays an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial organogenesis | mucin 2, oligomeric mucus/gel-forming; Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer | 0.921 |
MUC6 | MUC5AC | ENSP00000406861 | ENSP00000435591 | mucin 6, oligomeric mucus/gel-forming; May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Plays an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial organogenesis | mucin 5AC, oligomeric mucus/gel-forming | 0.913 |
MUC6 | MUC5B | ENSP00000406861 | ENSP00000436812 | mucin 6, oligomeric mucus/gel-forming; May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Plays an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial organogenesis | mucin 5B, oligomeric mucus/gel-forming | 0.920 |