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RPL10L RPL10L RPL10 RPL10 RPL8 RPL8 RPL30 RPL30 RPL29 RPL29 RPS4Y2 RPS4Y2 RPS28 RPS28 RPL23 RPL23 RPL10A RPL10A RPL18A RPL18A RPL13 RPL13 RPS18 RPS18 RPS23 RPS23 RPL3L RPL3L RPL21 RPL21 RPS7 RPS7 UPF2 UPF2 RPS15A RPS15A RPS27L RPS27L RPS27A RPS27A RPS4Y1 RPS4Y1 UPF1 UPF1 RPS15 RPS15 RPS19 RPS19 RPLP1 RPLP1 PPP2R2A PPP2R2A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
RPL18Aribosomal protein L18a (176 aa)
RPS4Y1ribosomal protein S4, Y-linked 1 (263 aa)
RPL8ribosomal protein L8 (257 aa)
UPF1UPF1 regulator of nonsense transcripts homolog (yeast); RNA-dependent helicase and ATPase required for nonsense- mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. Recruited by release factors to stalled ribosomes together with the SMG1C protein kinase complex to form the transient SURF (SMG1-UPF1-eRF1- eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) (loc [...] (1118 aa)
RPL3Lribosomal protein L3-like (407 aa)
RPS27Aribosomal protein S27a (156 aa)
RPL30ribosomal protein L30 (115 aa)
RPS4Y2ribosomal protein S4, Y-linked 2 (263 aa)
RPL29ribosomal protein L29 (159 aa)
RPS23ribosomal protein S23 (143 aa)
RPL10Lribosomal protein L10-like; May play a role in compensating for the inactivated X- linked gene during spermatogenesis (214 aa)
RPL13ribosomal protein L13 (211 aa)
RPS15Aribosomal protein S15a (130 aa)
PPP2R2Aprotein phosphatase 2, regulatory subunit B, alpha; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment (457 aa)
RPS27Lribosomal protein S27-like (84 aa)
RPS7ribosomal protein S7; Required for rRNA maturation (194 aa)
RPL10ribosomal protein L10 (214 aa)
RPL21ribosomal protein L21 (160 aa)
RPLP1ribosomal protein, large, P1; Plays an important role in the elongation step of protein synthesis (114 aa)
UPF2UPF2 regulator of nonsense transcripts homolog (yeast) (1272 aa)
RPL10Aribosomal protein L10a (217 aa)
RPL23ribosomal protein L23 (140 aa)
RPS18ribosomal protein S18 (152 aa)
RPS15ribosomal protein S15 (145 aa)
RPS19ribosomal protein S19; Required for pre-rRNA processing and maturation of 40S ribosomal subunits (145 aa)
RPS28ribosomal protein S28 (69 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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