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KCNA5 KCNA5 KCNB1 KCNB1 KCNAB3 KCNAB3 KCNV1 KCNV1 KCNS2 KCNS2 KCND3 KCND3 KCNG3 KCNG3 KCNF1 KCNF1 KCNG2 KCNG2 KCNA7 KCNA7 KCNA3 KCNA3 KCNQ1 KCNQ1 KCNQ2 KCNQ2 KCNS3 KCNS3 KCNA6 KCNA6 KCNS1 KCNS1 KCNC1 KCNC1 KCND2 KCND2 KCNG4 KCNG4 KCNQ5 KCNQ5 KCNA10 KCNA10 KCNA4 KCNA4 KCNC4 KCNC4 KCNQ4 KCNQ4 KCNG1 KCNG1 KCNA2 KCNA2
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
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colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
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textmining edge
textmining
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co-expression
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Your Input:
KCNQ1potassium voltage-gated channel, KQT-like subfamily, member 1; Probably important in cardiac repolarization. Associates with KCNE1 (MinK) to form the I(Ks) cardiac potassium current. Elicits a rapidly activating, potassium-selective outward current. Muscarinic agonist oxotremorine-M strongly suppresses KCNQ1/KCNE1 current in CHO cells in which cloned KCNQ1/KCNE1 channels were coexpressed with M1 muscarinic receptors. May associate also with KCNE3 (MiRP2) to form the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions, which is reduced in [...] (676 aa)
KCNA7potassium voltage-gated channel, shaker-related subfamily, member 7; Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient (By similarity) (456 aa)
KCNA5potassium voltage-gated channel, shaker-related subfamily, member 5; Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. This channel displays rapid activation and slow inactivation. May play a role in regulating the secretion of insulin in normal pancreatic islets. Isoform 2 exhibits a voltage-dependent recovery from inacti [...] (613 aa)
KCNQ4potassium voltage-gated channel, KQT-like subfamily, member 4; Probably important in the regulation of neuronal excitability. May underlie a potassium current involved in regulating the excitability of sensory cells of the cochlea. KCNQ4 channels are blocked by linopirdin, XE991 and bepridil, whereas clofilium is without significant effect. Muscarinic agonist oxotremorine-M strongly suppress KCNQ4 current in CHO cells in which cloned KCNQ4 channels were coexpressed with M1 muscarinic receptors (695 aa)
KCNC1potassium voltage-gated channel, Shaw-related subfamily, member 1; Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient (585 aa)
KCNA6potassium voltage-gated channel, shaker-related subfamily, member 6; Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient (529 aa)
KCNS2potassium voltage-gated channel, delayed-rectifier, subfamily S, member 2; Potassium channel subunit. Modulates channel activity and reduces the ion flow (By similarity) (477 aa)
KCNF1potassium voltage-gated channel, subfamily F, member 1; Putative voltage-gated potassium channel (494 aa)
KCNV1potassium channel, subfamily V, member 1; Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes (500 aa)
KCNAB3potassium voltage-gated channel, shaker-related subfamily, beta member 3; Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. Alters the functional properties of Kv1.5 (404 aa)
KCNG3potassium voltage-gated channel, subfamily G, member 3; Potassium channel subunit. Modulates channel activity (436 aa)
KCNS3potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3; Potassium channel subunit. Modulates channel activity and reduces the ion flow (By similarity) (491 aa)
KCNS1potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1; Potassium channel subunit. Modulates channel activity and reduces the ion flow (By similarity) (526 aa)
KCNG4potassium voltage-gated channel, subfamily G, member 4; Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values (519 aa)
KCNA2potassium voltage-gated channel, shaker-related subfamily, member 2; Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient (499 aa)
KCNG2potassium voltage-gated channel, subfamily G, member 2; Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values (466 aa)
KCND3potassium voltage-gated channel, Shal-related subfamily, member 3; Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits (655 aa)
KCNA4potassium voltage-gated channel, shaker-related subfamily, member 4; Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient (653 aa)
KCND2potassium voltage-gated channel, Shal-related subfamily, member 2; Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits (630 aa)
KCNQ5potassium voltage-gated channel, KQT-like subfamily, member 5 (951 aa)
KCNQ2potassium voltage-gated channel, KQT-like subfamily, member 2 (872 aa)
KCNA3potassium voltage-gated channel, shaker-related subfamily, member 3; Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient (575 aa)
KCNA10potassium voltage-gated channel, shaker-related subfamily, member 10; Mediates voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. The channel activity is up-regulated by cAMP (511 aa)
KCNC4potassium voltage-gated channel, Shaw-related subfamily, member 4; This protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient (635 aa)
KCNG1potassium voltage-gated channel, subfamily G, member 1; Probable potassium channel subunit. May need to associate with another protein to form a functional channel. May modulate channel activity (513 aa)
KCNB1potassium voltage-gated channel, Shab-related subfamily, member 1; Mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient (858 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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