ATP-binding cassette, sub-family D (ALD), member 3; Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity

acyl-CoA synthetase long-chain family member 6; Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid

ATP-binding cassette, sub-family D (ALD), member 3; Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity

peroxisomal biogenesis factor 7; Binds to the N-terminal PTS2-type peroxisomal targeting signal and plays an essential role in peroxisomal protein import

ATP-binding cassette, sub-family D (ALD), member 3; Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity

phytanoyl-CoA 2-hydroxylase; Converts phytanoyl-CoA to 2-hydroxyphytanoyl-CoA

ATP-binding cassette, sub-family D (ALD), member 3; Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity

solute carrier family 27 (fatty acid transporter), member 2; Acyl-CoA synthetase probably involved in bile acid metabolism. Proposed to activate C27 precurors of bile acids to their CoA thioesters derivatives before side chain cleavage via peroxisomal beta-oxidation occurs. In vitro, activates 3-alpha,7- alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. Does not utilize C24 bile acids as substrates. In vitro, also activates long- and branched-chain fatty acids and may have additional roles in fat [...]

ATP-binding cassette, sub-family D (ALD), member 3; Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity

ubiquitin C

acyl-CoA synthetase long-chain family member 6; Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid

ATP-binding cassette, sub-family D (ALD), member 3; Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity

acyl-CoA synthetase long-chain family member 6; Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid

phytanoyl-CoA 2-hydroxylase; Converts phytanoyl-CoA to 2-hydroxyphytanoyl-CoA

acyl-CoA synthetase long-chain family member 6; Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid

solute carrier family 27 (fatty acid transporter), member 2; Acyl-CoA synthetase probably involved in bile acid metabolism. Proposed to activate C27 precurors of bile acids to their CoA thioesters derivatives before side chain cleavage via peroxisomal beta-oxidation occurs. In vitro, activates 3-alpha,7- alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. Does not utilize C24 bile acids as substrates. In vitro, also activates long- and branched-chain fatty acids and may have additional roles in fat [...]

COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis); Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association [...]

phytanoyl-CoA 2-hydroxylase; Converts phytanoyl-CoA to 2-hydroxyphytanoyl-CoA

COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis); Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association [...]

ubiquitin C

ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R); Involved in 3’-UTR ARE-mediated MYC stabilization. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA and AUUUUUA motifs. Binds preferentially to the 5’-UUUU[AG]UUU-3’ motif in vitro

ubiquitin C

coagulation factor VIII, procoagulant component; Factor VIII, along with calcium and phospholipid, acts as a cofactor for factor IXa when it converts factor X to the activated form, factor Xa

phytanoyl-CoA 2-hydroxylase; Converts phytanoyl-CoA to 2-hydroxyphytanoyl-CoA

FK506 binding protein 4, 59kDa; Immunophilin protein with PPIase and co-chaperone activities (By similarity). Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments (By similarity). The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembl [...]

phytanoyl-CoA 2-hydroxylase; Converts phytanoyl-CoA to 2-hydroxyphytanoyl-CoA

FK506 binding protein 4, 59kDa; Immunophilin protein with PPIase and co-chaperone activities (By similarity). Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments (By similarity). The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembl [...]

ubiquitin C

2-hydroxyacyl-CoA lyase 1; Catalyzes a carbon-carbon cleavage reaction; cleaves a 2-hydroxy-3-methylacyl-CoA into formyl-CoA and a 2-methyl-branched fatty aldehyde

phytanoyl-CoA 2-hydroxylase; Converts phytanoyl-CoA to 2-hydroxyphytanoyl-CoA

2-hydroxyacyl-CoA lyase 1; Catalyzes a carbon-carbon cleavage reaction; cleaves a 2-hydroxy-3-methylacyl-CoA into formyl-CoA and a 2-methyl-branched fatty aldehyde

ubiquitin C

histone acetyltransferase 1; Acetylates soluble but not nucleosomal histone H4 at ’Lys-5’ (H4K5ac) and ’Lys-12’ (H4K12ac) and, to a lesser extent, acetylates histone H2A at ’Lys-5’ (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. May be involved in nucleosome assembly during DNA replication and repair as part of the histone H3.1 and H3.3 complexes. May play a role in DNA repair in response to free radical damage

ubiquitin C

peroxisomal biogenesis factor 7; Binds to the N-terminal PTS2-type peroxisomal targeting signal and plays an essential role in peroxisomal protein import

ATP-binding cassette, sub-family D (ALD), member 3; Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity

peroxisomal biogenesis factor 7; Binds to the N-terminal PTS2-type peroxisomal targeting signal and plays an essential role in peroxisomal protein import

phytanoyl-CoA 2-hydroxylase; Converts phytanoyl-CoA to 2-hydroxyphytanoyl-CoA

phytanoyl-CoA 2-hydroxylase; Converts phytanoyl-CoA to 2-hydroxyphytanoyl-CoA

ATP-binding cassette, sub-family D (ALD), member 3; Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity