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STRINGSTRING
SERPINA1 SERPINA1 SERPING1 SERPING1 SERPINA9 SERPINA9 KIAA0664 KIAA0664 SERPINB2 SERPINB2 SERPINB7 SERPINB7 SERPINB13 SERPINB13 SERPINF2 SERPINF2 SERPINA10 SERPINA10 SERPINA4 SERPINA4 PACS2 PACS2 LRRC46 LRRC46 SERPINA7 SERPINA7 SERPINB4 SERPINB4 SERPINC1 SERPINC1 WDR37 WDR37 SERPINB6 SERPINB6 SERPINB8 SERPINB8 SERPINI2 SERPINI2 PACS1 PACS1 SERPINA5 SERPINA5 SERPINA11 SERPINA11 SERPIND1 SERPIND1 SERPINA6 SERPINA6 AGT AGT SETD2 SETD2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
SERPIND1serpin peptidase inhibitor, clade D (heparin cofactor), member 1; Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner (499 aa)
SERPINA10serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10; Inhibits activity of the coagulation protease factor Xa in the presence of PROZ, calcium and phospholipids. Also inhibits factor XIa in the absence of cofactors (444 aa)
WDR37WD repeat domain 37 (494 aa)
SERPINI2serpin peptidase inhibitor, clade I (pancpin), member 2 (405 aa)
LRRC46leucine rich repeat containing 46 (321 aa)
SERPING1serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 (500 aa)
SERPINA4serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4; Inhibits human amidolytic and kininogenase activities of tissue kallikrein. Inhibition is achieved by formation of an equimolar, heat- and SDS-stable complex between the inhibitor and the enzyme, and generation of a small C-terminal fragment of the inhibitor due to cleavage at the reactive site by tissue kallikrein (427 aa)
SERPINB2serpin peptidase inhibitor, clade B (ovalbumin), member 2; Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell- derived PAI-1 (415 aa)
PACS1phosphofurin acidic cluster sorting protein 1 (963 aa)
SERPINF2serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2; Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin (491 aa)
SERPINA7serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7; Major thyroid hormone transport protein in serum (415 aa)
SERPINB8serpin peptidase inhibitor, clade B (ovalbumin), member 8 (374 aa)
SERPINA5serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5; Heparin-dependent serine protease inhibitor acting in body fluids and secretions. Inactivates serine proteases by binding irreversibly to their serine activation site. Involved in the regulation of intravascular and extravascular proteolytic activities. Plays hemostatic roles in the blood plasma. Acts as a procoagulant and proinflammatory factor by inhibiting the anticoagulant activated protein C factor as well as the generation of activated protein C factor by the thrombin/thrombomodulin complex. Acts [...] (406 aa)
SERPINA11serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11 (422 aa)
SERPINA9serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9 (435 aa)
SERPINB7serpin peptidase inhibitor, clade B (ovalbumin), member 7; Might function as an inhibitor of Lys-specific proteases. Might influence the maturation of megakaryocytes via its action as a serpin (380 aa)
SERPINB6serpin peptidase inhibitor, clade B (ovalbumin), member 6; May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood (By similarity). Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress and loss of this protection results in cell death and sensorineural hearing loss (376 aa)
SERPINB13serpin peptidase inhibitor, clade B (ovalbumin), member 13; May play a role in the proliferation or differentiation of keratinocytes (391 aa)
SERPINA6serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6; Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species (405 aa)
SERPINB4serpin peptidase inhibitor, clade B (ovalbumin), member 4; May act as a protease inhibitor to modulate the host immune response against tumor cells (390 aa)
SERPINA1serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 (418 aa)
AGTangiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis (485 aa)
SERPINC1serpin peptidase inhibitor, clade C (antithrombin), member 1 (464 aa)
SETD2SET domain containing 2 (2564 aa)
KIAA0664KIAA0664; Involved in proper cytoplasmic distribution of mitochondria (By similarity) (1309 aa)
PACS2phosphofurin acidic cluster sorting protein 2; Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct [...] (893 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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