node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CASP1 | CASP4 | ENSP00000410076 | ENSP00000388566 | caspase 1, apoptosis-related cysteine peptidase; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis | caspase 4, apoptosis-related cysteine peptidase; Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves caspase-1 | 0.957 |
CASP1 | IL18BP | ENSP00000410076 | ENSP00000260049 | caspase 1, apoptosis-related cysteine peptidase; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis | interleukin 18 binding protein; Isoform A binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response | 0.506 |
CASP1 | IL37 | ENSP00000410076 | ENSP00000263326 | caspase 1, apoptosis-related cysteine peptidase; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis | interleukin 37; Suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation | 0.772 |
CASP4 | CASP1 | ENSP00000388566 | ENSP00000410076 | caspase 4, apoptosis-related cysteine peptidase; Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves caspase-1 | caspase 1, apoptosis-related cysteine peptidase; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis | 0.957 |
CASP4 | IL37 | ENSP00000388566 | ENSP00000263326 | caspase 4, apoptosis-related cysteine peptidase; Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves caspase-1 | interleukin 37; Suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation | 0.566 |
IL18BP | CASP1 | ENSP00000260049 | ENSP00000410076 | interleukin 18 binding protein; Isoform A binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response | caspase 1, apoptosis-related cysteine peptidase; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis | 0.506 |
IL18BP | IL18R1 | ENSP00000260049 | ENSP00000233957 | interleukin 18 binding protein; Isoform A binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response | interleukin 18 receptor 1; Receptor for interleukin 18 (IL-18). Binding to the agonist leads to the activation of NF-kappa-B | 0.405 |
IL18BP | IL37 | ENSP00000260049 | ENSP00000263326 | interleukin 18 binding protein; Isoform A binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response | interleukin 37; Suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation | 0.743 |
IL18R1 | IL18BP | ENSP00000233957 | ENSP00000260049 | interleukin 18 receptor 1; Receptor for interleukin 18 (IL-18). Binding to the agonist leads to the activation of NF-kappa-B | interleukin 18 binding protein; Isoform A binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response | 0.405 |
IL18R1 | IL37 | ENSP00000233957 | ENSP00000263326 | interleukin 18 receptor 1; Receptor for interleukin 18 (IL-18). Binding to the agonist leads to the activation of NF-kappa-B | interleukin 37; Suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation | 0.683 |
IL37 | CASP1 | ENSP00000263326 | ENSP00000410076 | interleukin 37; Suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation | caspase 1, apoptosis-related cysteine peptidase; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis | 0.772 |
IL37 | CASP4 | ENSP00000263326 | ENSP00000388566 | interleukin 37; Suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation | caspase 4, apoptosis-related cysteine peptidase; Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves caspase-1 | 0.566 |
IL37 | IL18BP | ENSP00000263326 | ENSP00000260049 | interleukin 37; Suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation | interleukin 18 binding protein; Isoform A binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response | 0.743 |
IL37 | IL18R1 | ENSP00000263326 | ENSP00000233957 | interleukin 37; Suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation | interleukin 18 receptor 1; Receptor for interleukin 18 (IL-18). Binding to the agonist leads to the activation of NF-kappa-B | 0.683 |
IL37 | SMAD3 | ENSP00000263326 | ENSP00000332973 | interleukin 37; Suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation | SMAD family member 3 | 0.961 |
SMAD3 | IL37 | ENSP00000332973 | ENSP00000263326 | SMAD family member 3 | interleukin 37; Suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation | 0.961 |