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BCL6 | B-cell CLL/lymphoma 6; Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis (706 aa) | |||
TICAM1 | toll-like receptor adaptor molecule 1; Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF- kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein- interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively (712 aa) | |||
PARP12 | poly (ADP-ribose) polymerase family, member 12 (701 aa) | |||
PHF11 | PHD finger protein 11; Positive regulator of Th1-type cytokine gene expression (331 aa) |