Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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 | PYCRL | pyrroline-5-carboxylate reductase-like (286 aa) | ||
 | LAP3 | leucine aminopeptidase 3; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (519 aa) | ||
 | COL21A1 | collagen, type XXI, alpha 1 (957 aa) | ||
 | COL8A1 | collagen, type VIII, alpha 1; Macromolecular component of the subendothelium. Major component of the Descemet’s membrane (basement membrane) of corneal endothelial cells. Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis (744 aa) | ||
 | P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I; Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins (534 aa) | ||
 | COL6A5 | collagen, type VI, alpha 5 (2615 aa) | ||
 | COL6A3 | collagen, type VI, alpha 3; Collagen VI acts as a cell-binding protein (3177 aa) | ||
 | COL1A2 | collagen, type I, alpha 2 (1366 aa) | ||
 | COL14A1 | collagen, type XIV, alpha 1 (1796 aa) | ||
 | COL8A2 | collagen, type VIII, alpha 2; Macromolecular component of the subendothelium. Major component of the Descemet’s membrane (basement membrane) of corneal endothelial cells. Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis (By similarity) (703 aa) | ||
 | COL12A1 | collagen, type XII, alpha 1; Type XII collagen interacts with type I collagen- containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix (By similarity) (3063 aa) | ||
 | PYCR1 | pyrroline-5-carboxylate reductase 1; Housekeeping enzyme that catalyzes the last step in proline biosynthesis. Can utilize both NAD and NADP, but has higher affinity for NAD. Involved in the cellular response to oxidative stress (319 aa) | ||
 | COL4A5 | collagen, type IV, alpha 5; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a ’chicken-wire’ meshwork together with laminins, proteoglycans and entactin/nidogen (1691 aa) | ||
 | COL7A1 | collagen, type VII, alpha 1; Stratified squamous epithelial basement membrane protein that forms anchoring fibrils which may contribute to epithelial basement membrane organization and adherence by interacting with extracellular matrix (ECM) proteins such as type IV collagen (2944 aa) | ||
 | COL17A1 | collagen, type XVII, alpha 1; May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane (1497 aa) | ||
 | COL18A1 | collagen, type XVIII, alpha 1 (1519 aa) | ||
 | PRODH | proline dehydrogenase (oxidase) 1 (600 aa) | ||
 | COL9A1 | collagen, type IX, alpha 1 (921 aa) | ||
 | COL6A6 | collagen, type VI, alpha 6; Collagen VI acts as a cell-binding protein (By similarity) (2263 aa) | ||
 | COL24A1 | collagen, type XXIV, alpha 1; May participate in regulating type I collagen fibrillogenesis at specific anatomical locations during fetal development (1714 aa) | ||
 | COL9A2 | collagen, type IX, alpha 2; Structural component of hyaline cartilage and vitreous of the eye (689 aa) | ||
 | COL16A1 | collagen, type XVI, alpha 1; Involved in mediating cell attachment and inducing integrin-mediated cellular reactions, such as cell spreading and alterations in cell morphology (1604 aa) | ||
 | COL2A1 | collagen, type II, alpha 1 (1487 aa) | ||
 | COL23A1 | collagen, type XXIII, alpha 1 (540 aa) | ||
 | COL28A1 | collagen, type XXVIII, alpha 1; May act as a cell-binding protein (1125 aa) | ||
 | P5CR2 | Uncharacterized protein (359 aa) | ||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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