Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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 | TMEM132A | transmembrane protein 132A; May play a role in embryonic and postnatal development of the brain. Increased resistance to cell death induced by serum starvation in cultured cells. Regulates cAMP-induced GFAP gene expression via STAT3 phosphorylation (By similarity) (1024 aa) | ||
 | TMEM131 | transmembrane protein 131; May play a role in the immune response to viral infection (By similarity) (1883 aa) | ||
 | SIAE | sialic acid acetylesterase; Catalyzes the removal of O-acetyl ester groups from position 9 of the parent sialic acid, N-acetylneuraminic acid (523 aa) | ||
 | ARSB | arylsulfatase B (533 aa) | ||
 | MAN2B2 | mannosidase, alpha, class 2B, member 2 (1009 aa) | ||
 | NAAA | N-acylethanolamine acid amidase; Degrades bioactive fatty acid amides to their corresponding acids, with the following preference- N- palmitoylethanolamine > N-myristoylethanolamine > N- lauroylethanolamine = N-stearoylethanolamine > N- arachidonoylethanolamine > N-oleoylethanolamine. Also exhibits weak hydrolytic activity against the ceramides N- lauroylsphingosine and N-palmitoylsphingosine (359 aa) | ||
 | POC1A | POC1 centriolar protein homolog A (Chlamydomonas); Involved in early steps of centriole duplication, as well as in the later steps of centriole length control. Required for ciliogenesis (407 aa) | ||
 | CNTNAP3 | contactin associated protein-like 3 (1288 aa) | ||
 | LAMB2 | laminin, beta 2 (laminin S); Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components (1798 aa) | ||
 | SGSH | N-sulfoglucosamine sulfohydrolase (502 aa) | ||
 | DCBLD2 | discoidin, CUB and LCCL domain containing 2 (775 aa) | ||
 | OAF | OAF homolog (Drosophila) (273 aa) | ||
 | COL18A1 | collagen, type XVIII, alpha 1 (1519 aa) | ||
 | MANEA | mannosidase, endo-alpha (462 aa) | ||
 | NRP2 | neuropilin 2 (931 aa) | ||
 | SEPN1 | selenoprotein N, 1 (590 aa) | ||
 | MANEAL | mannosidase, endo-alpha-like (457 aa) | ||
 | ENTPD6 | ectonucleoside triphosphate diphosphohydrolase 6 (putative); Might support glycosylation reactions in the Golgi apparatus and, when released from cells, might catalyze the hydrolysis of extracellular nucleotides. Hydrolyzes preferentially nucleoside 5’-diphosphates, nucleoside 5’-triphosphates are hydrolyzed only to a minor extent, there is no hydrolysis of nucleoside 5’-monophosphates. The order of activity with different substrates is GDP > IDP >> UDP = CDP >> ADP (By similarity) (484 aa) | ||
 | TMEM2 | transmembrane protein 2 (1383 aa) | ||
 | ARSK | arylsulfatase family, member K (536 aa) | ||
 | TENM3 | teneurin transmembrane protein 3; Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Promotes axon guidance and homophilic cell adhesion. Plays a role in the development of the visual pathway; regulates the formation in ipsilateral retinal mapping to both the dorsal lateral geniculate nucleus (dLGN) and the superior colliculus (SC). May be involved in the differentiation of the fibroblast-like cells in the superficial layer of mandibular condylar cartilage into chondrocytes. May function as a cellular signal transducer (By sim [...] (2699 aa) | ||
 | CPE | carboxypeptidase E; Removes residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone processing. Processes proinsulin (476 aa) | ||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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