node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BMP2 | BMP4 | ENSP00000368104 | ENSP00000245451 | bone morphogenetic protein 2; Induces cartilage and bone formation | bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) | 0.903 |
BMP2 | BMP5 | ENSP00000368104 | ENSP00000359866 | bone morphogenetic protein 2; Induces cartilage and bone formation | bone morphogenetic protein 5; Induces cartilage and bone formation | 0.969 |
BMP2 | BMP6 | ENSP00000368104 | ENSP00000283147 | bone morphogenetic protein 2; Induces cartilage and bone formation | bone morphogenetic protein 6; Induces cartilage and bone formation | 0.709 |
BMP2 | BMP7 | ENSP00000368104 | ENSP00000379204 | bone morphogenetic protein 2; Induces cartilage and bone formation | bone morphogenetic protein 7; Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis | 0.968 |
BMP2 | CHRDL2 | ENSP00000368104 | ENSP00000263671 | bone morphogenetic protein 2; Induces cartilage and bone formation | chordin-like 2; May inhibit BMPs activity by blocking their interaction with their receptors. Has a negative regulator effect on the cartilage formation/regeneration from immature mesenchymal cells, by preventing or reducing the rate of matrix accumulation (By similarity). Implicated in tumor angiogenesis. May play a role during myoblast and osteoblast differentiation, and maturation | 0.939 |
BMP2 | GDF5 | ENSP00000368104 | ENSP00000363489 | bone morphogenetic protein 2; Induces cartilage and bone formation | growth differentiation factor 5; Could be involved in bone and cartilage formation. Chondrogenic signaling is mediated by the high-affinity receptor BMPR1B | 0.916 |
BMP4 | BMP2 | ENSP00000245451 | ENSP00000368104 | bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) | bone morphogenetic protein 2; Induces cartilage and bone formation | 0.903 |
BMP4 | BMP5 | ENSP00000245451 | ENSP00000359866 | bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) | bone morphogenetic protein 5; Induces cartilage and bone formation | 0.969 |
BMP4 | BMP6 | ENSP00000245451 | ENSP00000283147 | bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) | bone morphogenetic protein 6; Induces cartilage and bone formation | 0.709 |
BMP4 | BMP7 | ENSP00000245451 | ENSP00000379204 | bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) | bone morphogenetic protein 7; Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis | 0.969 |
BMP4 | CHRDL2 | ENSP00000245451 | ENSP00000263671 | bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) | chordin-like 2; May inhibit BMPs activity by blocking their interaction with their receptors. Has a negative regulator effect on the cartilage formation/regeneration from immature mesenchymal cells, by preventing or reducing the rate of matrix accumulation (By similarity). Implicated in tumor angiogenesis. May play a role during myoblast and osteoblast differentiation, and maturation | 0.667 |
BMP4 | GDF5 | ENSP00000245451 | ENSP00000363489 | bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) | growth differentiation factor 5; Could be involved in bone and cartilage formation. Chondrogenic signaling is mediated by the high-affinity receptor BMPR1B | 0.916 |
BMP5 | BMP2 | ENSP00000359866 | ENSP00000368104 | bone morphogenetic protein 5; Induces cartilage and bone formation | bone morphogenetic protein 2; Induces cartilage and bone formation | 0.969 |
BMP5 | BMP4 | ENSP00000359866 | ENSP00000245451 | bone morphogenetic protein 5; Induces cartilage and bone formation | bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) | 0.969 |
BMP5 | BMP7 | ENSP00000359866 | ENSP00000379204 | bone morphogenetic protein 5; Induces cartilage and bone formation | bone morphogenetic protein 7; Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis | 0.902 |
BMP5 | CHRDL2 | ENSP00000359866 | ENSP00000263671 | bone morphogenetic protein 5; Induces cartilage and bone formation | chordin-like 2; May inhibit BMPs activity by blocking their interaction with their receptors. Has a negative regulator effect on the cartilage formation/regeneration from immature mesenchymal cells, by preventing or reducing the rate of matrix accumulation (By similarity). Implicated in tumor angiogenesis. May play a role during myoblast and osteoblast differentiation, and maturation | 0.802 |
BMP6 | BMP2 | ENSP00000283147 | ENSP00000368104 | bone morphogenetic protein 6; Induces cartilage and bone formation | bone morphogenetic protein 2; Induces cartilage and bone formation | 0.709 |
BMP6 | BMP4 | ENSP00000283147 | ENSP00000245451 | bone morphogenetic protein 6; Induces cartilage and bone formation | bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) | 0.709 |
BMP6 | CHRDL2 | ENSP00000283147 | ENSP00000263671 | bone morphogenetic protein 6; Induces cartilage and bone formation | chordin-like 2; May inhibit BMPs activity by blocking their interaction with their receptors. Has a negative regulator effect on the cartilage formation/regeneration from immature mesenchymal cells, by preventing or reducing the rate of matrix accumulation (By similarity). Implicated in tumor angiogenesis. May play a role during myoblast and osteoblast differentiation, and maturation | 0.747 |
BMP7 | BMP2 | ENSP00000379204 | ENSP00000368104 | bone morphogenetic protein 7; Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis | bone morphogenetic protein 2; Induces cartilage and bone formation | 0.968 |