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CD93 | CD93 molecule; Receptor (or element of a larger receptor complex) for C1q, mannose-binding lectin (MBL2) and pulmonary surfactant protein A (SPA). May mediate the enhancement of phagocytosis in monocytes and macrophages upon interaction with soluble defense collagens. May play a role in intercellular adhesion (652 aa) | |||
JAG1 | jagged 1; Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity). Enhances fibroblast growth factor-induced angiogenesis (in vitro) (1218 aa) | |||
MIB1 | mindbomb E3 ubiquitin protein ligase 1 (1006 aa) | |||
SMAD2 | SMAD family member 2; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (467 aa) | |||
TANC1 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1; May be a scaffold component in the postsynaptic density (By similarity) (1861 aa) | |||
EPB41L5 | erythrocyte membrane protein band 4.1 like 5; May contribute to the correct positioning of tight junctions during the establishment of polarity in epithelial cells (733 aa) | |||
RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2; Guanine nucleotide exchange factor (GEF) for Rap1A, Rap1B and Rap2B GTPases. Does not interact with cAMP or cGMP (1499 aa) | |||
TSC1 | tuberous sclerosis 1; In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Seems not to be required for TSC2 GAP activity towards RHEB. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling (1164 aa) | |||
SUZ12 | suppressor of zeste 12 homolog (Drosophila); Polycomb group (PcG) protein. Component of the PRC2/EED- EZH2 complex, which methylates ’Lys-9’ (H3K9me) and ’Lys-27’ (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A (739 aa) | |||
JAG2 | jagged 2; Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development (By similarity) (1238 aa) | |||
SMAD3 | SMAD family member 3 (425 aa) | |||
UBC | ubiquitin C (685 aa) | |||
CRB1 | crumbs homolog 1 (Drosophila) (1406 aa) | |||
CRB2 | crumbs homolog 2 (Drosophila); May play a role in polarized cells morphogenesis (1285 aa) | |||
MAGI1 | membrane associated guanylate kinase, WW and PDZ domain containing 1; May play a role as scaffolding protein at cell-cell junctions. May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface (By similarity) (1462 aa) | |||
TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 (1990 aa) | |||
ATG12 | autophagy related 12; Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through an ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. The ATG12-ATG5 conjugate also regulates negatively the innate antiviral immune response by blocking the type I IFN production pathway through direct associ [...] (140 aa) | |||
MIB2 | mindbomb E3 ubiquitin protein ligase 2 (1070 aa) |