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LHX8 LHX8 SH2D1A SH2D1A ALX4 ALX4 OTP OTP LMO4 LMO4 IFT172 IFT172 LHX1 LHX1 LMX1B LMX1B TCAP TCAP LMO2 LMO2 LDB2 LDB2 ISL1 ISL1 LHX4 LHX4 PRRX1 PRRX1 ISL2 ISL2 LHX9 LHX9 LHX2 LHX2 LMO3 LMO3 FDX1L FDX1L DRGX DRGX SNRNP25 SNRNP25 RHOXF1 RHOXF1 ESX1 ESX1 DPRX DPRX RAX RAX ORC6 ORC6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
RHOXF1Rhox homeobox family, member 1; May be a transcription factor involved in reproductive processes (184 aa)
ORC6origin recognition complex, subunit 6; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication (252 aa)
ISL1ISL LIM homeobox 1; Binds and regulates the promoters of the insulin, glucagon and somatostatin genes. Involved in the specificarion of motor neurons in cooperation with LHX3 and LDB1 (By similarity) (349 aa)
PRRX1paired related homeobox 1; Acts as a transcriptional regulator of muscle creatine kinase (MCK) and so has a role in the establishment of diverse mesodermal muscle types. The protein binds to an A/T-rich element in the muscle creatine enhancer (By similarity) (245 aa)
LHX1LIM homeobox 1; Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis (406 aa)
LMO2LIM domain only 2 (rhombotin-like 1); Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state (227 aa)
IFT172intraflagellar transport 172 homolog (Chlamydomonas); Required for the maintenance and formation of cilia. Plays an indirect role in hedgehog (Hh) signaling, cilia being required for all activity of the hedgehog pathway (By similarity) (1749 aa)
LHX4LIM homeobox 4; May play a critical role in the development of respiratory control mechanisms and in the normal growth and maturation of the lung (By similarity) (390 aa)
ISL2ISL LIM homeobox 2; Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways (By similarity) (359 aa)
LHX8LIM homeobox 8; Transcription factor involved in differentiation of certain neurons and mesenchymal cells (By similarity) (356 aa)
OTPorthopedia homeobox; Probably involved in the differentiation of hypothalamic neuroendocrine cells (325 aa)
LDB2LIM domain binding 2; Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors (373 aa)
TCAPtitin-cap; Muscle assembly regulating factor. Mediates the antiparallel assembly of titin (TTN) molecules at the sarcomeric Z-disk (167 aa)
LMO3LIM domain only 3 (rhombotin-like 2) (145 aa)
ALX4ALX homeobox 4; Transcription factor involved in skull and limb development. Plays an essential role in craniofacial development, skin and hair follicle development (411 aa)
RAXretina and anterior neural fold homeobox; Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation. Binds to the photoreceptor conserved element-I (PCE-1/Ret 1) in the photoreceptor cell-specific arrestin promoter (346 aa)
LMX1BLIM homeobox transcription factor 1, beta; Essential for the specification of dorsal limb fate at both the zeugopodal and autopodal levels (406 aa)
LHX9LIM homeobox 9; Involved in gonadal development (By similarity) (397 aa)
LMO4LIM domain only 4; Probable transcriptional factor (By similarity) (165 aa)
SH2D1ASH2 domain containing 1A; Inhibitor of the SLAM self-association. Acts by blocking recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to a docking site in the SLAM cytoplasmic region. Mediates interaction between FYN and SLAMF1. May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3 (128 aa)
ESX1ESX homeobox 1; May coordinately regulate cell cycle progression and transcription during spermatogenesis. Inhibits degradation of polyubiquitinated cyclin A and cyclin B1 and thereby arrests the cell cycle at early M phase. ESXR1-N acts as a transcriptional repressor. Binds to the sequence 5’-TAATGTTATTA-3’ which is present within the first intron of the KRAS gene and inhibits its expression. ESXR1-C has the ability to inhibit cyclin turnover (406 aa)
LHX2LIM homeobox 2; Acts as a transcriptional activator. Stimulates the promoter of the alpha-glycoprotein gene. Transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types (By similarity) (406 aa)
DPRXdivergent-paired related homeobox; Putative transcription factor (By similarity) (191 aa)
SNRNP25small nuclear ribonucleoprotein 25kDa (U11/U12) (132 aa)
FDX1Lferredoxin 1-like; Essential for heme A and Fe/S protein biosynthesis (183 aa)
DRGXdorsal root ganglia homeobox; Transcription factor required for the formation of correct projections from nociceptive sensory neurons to the dorsal horn of the spinal cord and normal perception of pain (By similarity) (268 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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