26 items (Homo sapiens) - STRING network view

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	HGF	hepatocyte growth factor (hepapoietin A; scatter factor) (728 aa)
	IL10RA	interleukin 10 receptor, alpha; Receptor for IL10; binds IL10 with a high affinity (578 aa)
	CNTFR	ciliary neurotrophic factor receptor; Binds to CNTF. The alpha subunit provides the receptor specificity (372 aa)
	IL9R	interleukin 9 receptor; This is a receptor for interleukin-9 (521 aa)
	IL12RB2	interleukin 12 receptor, beta 2; Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production (862 aa)
	IL7	interleukin 7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation (177 aa)
	OSMR	oncostatin M receptor; Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events (979 aa)
	IL9	interleukin 9; Supports IL-2 independent and IL-4 independent growth of helper T-cells (144 aa)
	IL3	interleukin 3 (colony-stimulating factor, multiple); Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages (152 aa)
	CSF2	colony stimulating factor 2 (granulocyte-macrophage); Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes (144 aa)
	IL22RA2	interleukin 22 receptor, alpha 2; Isoform 2 is a receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses (263 aa)
	IL13	interleukin 13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses (146 aa)
	IL7R	interleukin 7 receptor (459 aa)
	IL20RA	interleukin 20 receptor, alpha; The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL20RA/IL10RB dimer is a receptor for IL26 (553 aa)
	IL28RA	interleukin 28 receptor, alpha (interferon, lambda receptor); The IFNLR1/IL10RB dimer is a receptor for IFNL1, IFNL2 and IFNL3. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Seems not to be essential for early virus- activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium (520 aa)
	IL6ST	interleukin 6 signal transducer (gp130, oncostatin M receptor); Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in embryonic development (By similarity). The type I OSM receptor is capable of transducing OSM-specific signaling events (918 aa)
	JAK1	Janus kinase 1; Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor (1154 aa)
	IL13RA1	interleukin 13 receptor, alpha 1; Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity (427 aa)
	CSF3R	colony stimulating factor 3 receptor (granulocyte); Receptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation. Plays a crucial role in the proliferation, differientation and survival of cells along the neutrophilic lineage. In addition it may function in some adhesion or recognition events at the cell surface (863 aa)
	IL2RG	interleukin 2 receptor, gamma; Common subunit for the receptors for a variety of interleukins (369 aa)
	IL2RA	interleukin 2 receptor, alpha; Receptor for interleukin-2 (272 aa)
	CRLF2	cytokine receptor-like factor 2; Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2 (By similarity). Implicated in the development of the hematopoietic system (256 aa)
	PRLR	prolactin receptor (622 aa)
	JAK3	Janus kinase 3; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor [...] (1124 aa)
	CSF2RA	colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) (434 aa)
	ENSG00000258728	Uncharacterized protein (280 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CNTFR	CSF2	ENSP00000242338	ENSP00000296871	ciliary neurotrophic factor receptor; Binds to CNTF. The alpha subunit provides the receptor specificity	colony stimulating factor 2 (granulocyte-macrophage); Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes	0.820
CNTFR	ENSG00000258728	ENSP00000242338	ENSP00000451792	ciliary neurotrophic factor receptor; Binds to CNTF. The alpha subunit provides the receptor specificity	Uncharacterized protein	0.654
CNTFR	IL13	ENSP00000242338	ENSP00000304915	ciliary neurotrophic factor receptor; Binds to CNTF. The alpha subunit provides the receptor specificity	interleukin 13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses	0.801
CNTFR	IL3	ENSP00000242338	ENSP00000296870	ciliary neurotrophic factor receptor; Binds to CNTF. The alpha subunit provides the receptor specificity	interleukin 3 (colony-stimulating factor, multiple); Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages	0.831
CNTFR	IL6ST	ENSP00000242338	ENSP00000338799	ciliary neurotrophic factor receptor; Binds to CNTF. The alpha subunit provides the receptor specificity	interleukin 6 signal transducer (gp130, oncostatin M receptor); Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in embryonic development (By similarity). The type I OSM receptor is capable of transducing OSM-specific signaling events	0.968
CNTFR	IL7	ENSP00000242338	ENSP00000263851	ciliary neurotrophic factor receptor; Binds to CNTF. The alpha subunit provides the receptor specificity	interleukin 7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation	0.810
CNTFR	IL9	ENSP00000242338	ENSP00000274520	ciliary neurotrophic factor receptor; Binds to CNTF. The alpha subunit provides the receptor specificity	interleukin 9; Supports IL-2 independent and IL-4 independent growth of helper T-cells	0.800
CNTFR	JAK1	ENSP00000242338	ENSP00000343204	ciliary neurotrophic factor receptor; Binds to CNTF. The alpha subunit provides the receptor specificity	Janus kinase 1; Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor	0.865
CNTFR	JAK3	ENSP00000242338	ENSP00000391676	ciliary neurotrophic factor receptor; Binds to CNTF. The alpha subunit provides the receptor specificity	Janus kinase 3; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor [...]	0.832
CNTFR	OSMR	ENSP00000242338	ENSP00000274276	ciliary neurotrophic factor receptor; Binds to CNTF. The alpha subunit provides the receptor specificity	oncostatin M receptor; Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events	0.777
CRLF2	CSF2	ENSP00000370979	ENSP00000296871	cytokine receptor-like factor 2; Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2 (By similarity). Implicated in the development of the hematopoietic system	colony stimulating factor 2 (granulocyte-macrophage); Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes	0.822
CRLF2	IL13	ENSP00000370979	ENSP00000304915	cytokine receptor-like factor 2; Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2 (By similarity). Implicated in the development of the hematopoietic system	interleukin 13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses	0.802
CRLF2	IL3	ENSP00000370979	ENSP00000296870	cytokine receptor-like factor 2; Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2 (By similarity). Implicated in the development of the hematopoietic system	interleukin 3 (colony-stimulating factor, multiple); Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages	0.832
CRLF2	IL7	ENSP00000370979	ENSP00000263851	cytokine receptor-like factor 2; Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2 (By similarity). Implicated in the development of the hematopoietic system	interleukin 7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation	0.898
CRLF2	IL7R	ENSP00000370979	ENSP00000306157	cytokine receptor-like factor 2; Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2 (By similarity). Implicated in the development of the hematopoietic system	interleukin 7 receptor	0.994
CRLF2	IL9	ENSP00000370979	ENSP00000274520	cytokine receptor-like factor 2; Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2 (By similarity). Implicated in the development of the hematopoietic system	interleukin 9; Supports IL-2 independent and IL-4 independent growth of helper T-cells	0.800
CRLF2	JAK1	ENSP00000370979	ENSP00000343204	cytokine receptor-like factor 2; Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2 (By similarity). Implicated in the development of the hematopoietic system	Janus kinase 1; Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor	0.898
CRLF2	JAK3	ENSP00000370979	ENSP00000391676	cytokine receptor-like factor 2; Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2 (By similarity). Implicated in the development of the hematopoietic system	Janus kinase 3; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor [...]	0.875
CSF2	CNTFR	ENSP00000296871	ENSP00000242338	colony stimulating factor 2 (granulocyte-macrophage); Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes	ciliary neurotrophic factor receptor; Binds to CNTF. The alpha subunit provides the receptor specificity	0.820
CSF2	CRLF2	ENSP00000296871	ENSP00000370979	colony stimulating factor 2 (granulocyte-macrophage); Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes	cytokine receptor-like factor 2; Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2 (By similarity). Implicated in the development of the hematopoietic system	0.822

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