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NT5C1A | 5’-nucleotidase, cytosolic IA; Dephosphorylates the 5’ and 2’(3’)-phosphates of deoxyribonucleotides and has a broad substrate specificity. Helps to regulate adenosine levels in heart during ischemia and hypoxia (368 aa) | |||
ADAT2 | adenosine deaminase, tRNA-specific 2; Probably participates in deamination of adenosine-34 to inosine in many tRNAs (By similarity) (191 aa) | |||
NT5C3 | 5’-nucleotidase, cytosolic III (336 aa) | |||
NT5C | 5’, 3’-nucleotidase, cytosolic; Dephosphorylates the 5’ and 2’(3’)-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP (201 aa) | |||
CDADC1 | cytidine and dCMP deaminase domain containing 1; May play an important role in testicular development and spermatogenesis (514 aa) | |||
CMPK2 | cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial; May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. May be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs (449 aa) | |||
NT5E | 5’-nucleotidase, ecto (CD73); Hydrolyzes extracellular nucleotides into membrane permeable nucleosides. Exhibits AMP-, NAD-, and NMN-nucleosidase activities (574 aa) | |||
SAMHD1 | SAM domain and HD domain 1; Putative nuclease involved in innate immune response by acting as a negative regulator of the cell-intrinsic antiviral response. May play a role in mediating proinflammatory responses to TNF-alpha signaling (626 aa) | |||
DGUOK | deoxyguanosine kinase; Required for the phosphorylation of several deoxyribonucleosides and certain nucleoside analogs widely employed as antiviral and chemotherapeutic agents (277 aa) | |||
DTYMK | deoxythymidylate kinase (thymidylate kinase); Catalyzes the conversion of dTMP to dTDP (212 aa) | |||
TYMS | thymidylate synthetase; Contributes to the de novo mitochondrial thymidylate biosynthesis pathway (313 aa) | |||
HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble); This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase (520 aa) | |||
ADAT3 | adenosine deaminase, tRNA-specific 3 (351 aa) | |||
NT5C2 | 5’-nucleotidase, cytosolic II; May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5’-monophosphate (IMP) and other purine nucleotides (561 aa) | |||
AK5 | adenylate kinase 5; Active on AMP and dAMP with ATP as a donor. When GTP is used as phosphate donor, the enzyme phosphorylates AMP, CMP, and to a small extent dCMP (562 aa) | |||
DCTD | dCMP deaminase; Supplies the nucleotide substrate for thymidylate synthetase (189 aa) | |||
PNP | purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) (289 aa) | |||
GUK1 | guanylate kinase 1; Essential for recycling GMP and indirectly, cGMP (241 aa) | |||
HMGCS2 | 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial); This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase (508 aa) | |||
CDA | cytidine deaminase; This enzyme scavenge exogenous and endogenous cytidine and 2’-deoxycytidine for UMP synthesis (146 aa) | |||
ITPA | inosine triphosphatase (nucleoside triphosphate pyrophosphatase) (194 aa) | |||
NT5M | 5’,3’-nucleotidase, mitochondrial; Dephosphorylates specifically the 5’ and 2’(3’)- phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP (228 aa) | |||
FCHSD2 | FCH and double SH3 domains 2 (740 aa) | |||
NT5C3L | 5’-nucleotidase, cytosolic III-like; Specifically hydrolyzes 7-methylguanosine monophosphate (m(7)GMP) to 7-methylguanosine and inorganic phosphate. The specific activity for m(7)GMP may protect cells against undesired salvage of m(7)GMP and its incorporation into nucleic acids. Also has weak activity for CMP. UMP and purine nucleotides are poor substrates (300 aa) | |||
FCHSD1 | FCH and double SH3 domains 1 (690 aa) | |||
ENSG00000250741 | NT5C1B-RDH14 readthrough (602 aa) |