node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCR5 | IFNG | ENSP00000292303 | ENSP00000229135 | chemokine (C-C motif) receptor 5 (gene/pseudogene) | interferon, gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity) | 0.420 |
CCR5 | IL18 | ENSP00000292303 | ENSP00000280357 | chemokine (C-C motif) receptor 5 (gene/pseudogene) | interleukin 18 (interferon-gamma-inducing factor); Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells | 0.917 |
CCR5 | IL18R1 | ENSP00000292303 | ENSP00000233957 | chemokine (C-C motif) receptor 5 (gene/pseudogene) | interleukin 18 receptor 1; Receptor for interleukin 18 (IL-18). Binding to the agonist leads to the activation of NF-kappa-B | 0.906 |
CCR5 | IL18RAP | ENSP00000292303 | ENSP00000264260 | chemokine (C-C motif) receptor 5 (gene/pseudogene) | interleukin 18 receptor accessory protein; Required for the high affinity binding of interleukin 18 (IL-18) to its receptor complex (By similarity). Together with IL18R1 mediates IL-18-dependent activation of NF-kappa-B and JNK | 0.906 |
CD48 | IL18 | ENSP00000357025 | ENSP00000280357 | CD48 molecule; Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation | interleukin 18 (interferon-gamma-inducing factor); Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells | 0.822 |
CD48 | IL18R1 | ENSP00000357025 | ENSP00000233957 | CD48 molecule; Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation | interleukin 18 receptor 1; Receptor for interleukin 18 (IL-18). Binding to the agonist leads to the activation of NF-kappa-B | 0.576 |
CD48 | IL18RAP | ENSP00000357025 | ENSP00000264260 | CD48 molecule; Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation | interleukin 18 receptor accessory protein; Required for the high affinity binding of interleukin 18 (IL-18) to its receptor complex (By similarity). Together with IL18R1 mediates IL-18-dependent activation of NF-kappa-B and JNK | 0.583 |
GADD45B | GADD45G | ENSP00000215631 | ENSP00000252506 | growth arrest and DNA-damage-inducible, beta; Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK | growth arrest and DNA-damage-inducible, gamma; Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK | 0.962 |
GADD45B | IL18 | ENSP00000215631 | ENSP00000280357 | growth arrest and DNA-damage-inducible, beta; Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK | interleukin 18 (interferon-gamma-inducing factor); Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells | 0.927 |
GADD45B | IL18R1 | ENSP00000215631 | ENSP00000233957 | growth arrest and DNA-damage-inducible, beta; Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK | interleukin 18 receptor 1; Receptor for interleukin 18 (IL-18). Binding to the agonist leads to the activation of NF-kappa-B | 0.900 |
GADD45B | IL18RAP | ENSP00000215631 | ENSP00000264260 | growth arrest and DNA-damage-inducible, beta; Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK | interleukin 18 receptor accessory protein; Required for the high affinity binding of interleukin 18 (IL-18) to its receptor complex (By similarity). Together with IL18R1 mediates IL-18-dependent activation of NF-kappa-B and JNK | 0.908 |
GADD45B | MAPK8 | ENSP00000215631 | ENSP00000353483 | growth arrest and DNA-damage-inducible, beta; Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK | mitogen-activated protein kinase 8; Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK8/JNK1. In turn, MAPK8/JNK1 phosphorylates a number of transcription factors, primarily components of AP-1 such as JU [...] | 0.459 |
GADD45B | NFKB1 | ENSP00000215631 | ENSP00000226574 | growth arrest and DNA-damage-inducible, beta; Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to b [...] | 0.515 |
GADD45G | GADD45B | ENSP00000252506 | ENSP00000215631 | growth arrest and DNA-damage-inducible, gamma; Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK | growth arrest and DNA-damage-inducible, beta; Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK | 0.962 |
GADD45G | IL18 | ENSP00000252506 | ENSP00000280357 | growth arrest and DNA-damage-inducible, gamma; Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK | interleukin 18 (interferon-gamma-inducing factor); Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells | 0.900 |
GADD45G | IL18R1 | ENSP00000252506 | ENSP00000233957 | growth arrest and DNA-damage-inducible, gamma; Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK | interleukin 18 receptor 1; Receptor for interleukin 18 (IL-18). Binding to the agonist leads to the activation of NF-kappa-B | 0.900 |
GADD45G | IL18RAP | ENSP00000252506 | ENSP00000264260 | growth arrest and DNA-damage-inducible, gamma; Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK | interleukin 18 receptor accessory protein; Required for the high affinity binding of interleukin 18 (IL-18) to its receptor complex (By similarity). Together with IL18R1 mediates IL-18-dependent activation of NF-kappa-B and JNK | 0.900 |
GADD45G | MAPK8 | ENSP00000252506 | ENSP00000353483 | growth arrest and DNA-damage-inducible, gamma; Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK | mitogen-activated protein kinase 8; Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK8/JNK1. In turn, MAPK8/JNK1 phosphorylates a number of transcription factors, primarily components of AP-1 such as JU [...] | 0.457 |
GADD45G | STAT4 | ENSP00000252506 | ENSP00000351255 | growth arrest and DNA-damage-inducible, gamma; Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK | signal transducer and activator of transcription 4; Carries out a dual function- signal transduction and activation of transcription. Involved in IL12 signaling | 0.509 |
IFNG | CCR5 | ENSP00000229135 | ENSP00000292303 | interferon, gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity) | chemokine (C-C motif) receptor 5 (gene/pseudogene) | 0.420 |