node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CLASP2 | KIAA1009 | ENSP00000419974 | ENSP00000385215 | cytoplasmic linker associated protein 2; Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is re [...] | KIAA1009; Functions in cell division regulating chromosome segregation and mitotic spindle assembly | 0.900 |
CLASP2 | NUDC | ENSP00000419974 | ENSP00000319664 | cytoplasmic linker associated protein 2; Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is re [...] | nuclear distribution C homolog (A. nidulans); Plays a role in neurogenesis and neuronal migration (By similarity). Necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Necessary for cytokinesis and cell proliferation | 0.900 |
CPA4 | LXN | ENSP00000222482 | ENSP00000264265 | carboxypeptidase A4; Metalloprotease that could be involved in the histone hyperacetylation pathway | latexin; Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4. May play a role in inflammation | 0.998 |
DPYD | LXN | ENSP00000359211 | ENSP00000264265 | dihydropyrimidine dehydrogenase | latexin; Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4. May play a role in inflammation | 0.590 |
GSG1L | LXN | ENSP00000394954 | ENSP00000264265 | GSG1-like; As a component of the inner core of AMPAR complex, modifies AMPA receptor (AMPAR) gating (By similarity) | latexin; Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4. May play a role in inflammation | 0.557 |
KIAA1009 | CLASP2 | ENSP00000385215 | ENSP00000419974 | KIAA1009; Functions in cell division regulating chromosome segregation and mitotic spindle assembly | cytoplasmic linker associated protein 2; Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is re [...] | 0.900 |
KIAA1009 | LXN | ENSP00000385215 | ENSP00000264265 | KIAA1009; Functions in cell division regulating chromosome segregation and mitotic spindle assembly | latexin; Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4. May play a role in inflammation | 0.482 |
LXN | CPA4 | ENSP00000264265 | ENSP00000222482 | latexin; Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4. May play a role in inflammation | carboxypeptidase A4; Metalloprotease that could be involved in the histone hyperacetylation pathway | 0.998 |
LXN | DPYD | ENSP00000264265 | ENSP00000359211 | latexin; Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4. May play a role in inflammation | dihydropyrimidine dehydrogenase | 0.590 |
LXN | GSG1L | ENSP00000264265 | ENSP00000394954 | latexin; Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4. May play a role in inflammation | GSG1-like; As a component of the inner core of AMPAR complex, modifies AMPA receptor (AMPAR) gating (By similarity) | 0.557 |
LXN | KIAA1009 | ENSP00000264265 | ENSP00000385215 | latexin; Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4. May play a role in inflammation | KIAA1009; Functions in cell division regulating chromosome segregation and mitotic spindle assembly | 0.482 |
LXN | PHACTR3 | ENSP00000264265 | ENSP00000360054 | latexin; Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4. May play a role in inflammation | phosphatase and actin regulator 3 | 0.482 |
LXN | PPM1A | ENSP00000264265 | ENSP00000327255 | latexin; Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4. May play a role in inflammation | protein phosphatase, Mg2+/Mn2+ dependent, 1A; Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling | 0.482 |
LXN | SH3BGRL | ENSP00000264265 | ENSP00000362308 | latexin; Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4. May play a role in inflammation | SH3 domain binding glutamic acid-rich protein like | 0.644 |
LXN | TMEM14A | ENSP00000264265 | ENSP00000211314 | latexin; Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4. May play a role in inflammation | transmembrane protein 14A | 0.557 |
LXN | ZKSCAN4 | ENSP00000264265 | ENSP00000366509 | latexin; Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4. May play a role in inflammation | zinc finger with KRAB and SCAN domains 4; May be involved in the transcriptional activation of MDM2 and EP300 genes | 0.742 |
NUDC | CLASP2 | ENSP00000319664 | ENSP00000419974 | nuclear distribution C homolog (A. nidulans); Plays a role in neurogenesis and neuronal migration (By similarity). Necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Necessary for cytokinesis and cell proliferation | cytoplasmic linker associated protein 2; Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is re [...] | 0.900 |
PHACTR3 | LXN | ENSP00000360054 | ENSP00000264265 | phosphatase and actin regulator 3 | latexin; Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4. May play a role in inflammation | 0.482 |
PPM1A | LXN | ENSP00000327255 | ENSP00000264265 | protein phosphatase, Mg2+/Mn2+ dependent, 1A; Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling | latexin; Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4. May play a role in inflammation | 0.482 |
SH3BGRL | LXN | ENSP00000362308 | ENSP00000264265 | SH3 domain binding glutamic acid-rich protein like | latexin; Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4. May play a role in inflammation | 0.644 |