node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CRLF2 | EPOR | ENSP00000370979 | ENSP00000222139 | cytokine receptor-like factor 2; Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2 (By similarity). Implicated in the development of the hematopoietic system | erythropoietin receptor; Receptor for erythropoietin. Mediates erythropoietin- induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase | 0.410 |
CRLF2 | IL11 | ENSP00000370979 | ENSP00000264563 | cytokine receptor-like factor 2; Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2 (By similarity). Implicated in the development of the hematopoietic system | interleukin 11; Directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production | 0.800 |
CRLF2 | IL7R | ENSP00000370979 | ENSP00000306157 | cytokine receptor-like factor 2; Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2 (By similarity). Implicated in the development of the hematopoietic system | interleukin 7 receptor | 0.994 |
CRLF2 | JAK1 | ENSP00000370979 | ENSP00000343204 | cytokine receptor-like factor 2; Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2 (By similarity). Implicated in the development of the hematopoietic system | Janus kinase 1; Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor | 0.898 |
CRLF2 | JAK2 | ENSP00000370979 | ENSP00000371067 | cytokine receptor-like factor 2; Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2 (By similarity). Implicated in the development of the hematopoietic system | Janus kinase 2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors, phosphorylate [...] | 0.965 |
CRLF2 | TYK2 | ENSP00000370979 | ENSP00000264818 | cytokine receptor-like factor 2; Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2 (By similarity). Implicated in the development of the hematopoietic system | tyrosine kinase 2; Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain | 0.846 |
CSF2RA | CSF3R | ENSP00000394227 | ENSP00000362195 | colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) | colony stimulating factor 3 receptor (granulocyte); Receptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation. Plays a crucial role in the proliferation, differientation and survival of cells along the neutrophilic lineage. In addition it may function in some adhesion or recognition events at the cell surface | 0.742 |
CSF2RA | EPOR | ENSP00000394227 | ENSP00000222139 | colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) | erythropoietin receptor; Receptor for erythropoietin. Mediates erythropoietin- induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase | 0.407 |
CSF2RA | IL11 | ENSP00000394227 | ENSP00000264563 | colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) | interleukin 11; Directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production | 0.800 |
CSF2RA | JAK1 | ENSP00000394227 | ENSP00000343204 | colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) | Janus kinase 1; Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor | 0.836 |
CSF2RA | JAK2 | ENSP00000394227 | ENSP00000371067 | colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) | Janus kinase 2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors, phosphorylate [...] | 0.939 |
CSF2RA | TYK2 | ENSP00000394227 | ENSP00000264818 | colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) | tyrosine kinase 2; Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain | 0.824 |
CSF3R | CSF2RA | ENSP00000362195 | ENSP00000394227 | colony stimulating factor 3 receptor (granulocyte); Receptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation. Plays a crucial role in the proliferation, differientation and survival of cells along the neutrophilic lineage. In addition it may function in some adhesion or recognition events at the cell surface | colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) | 0.742 |
CSF3R | EPOR | ENSP00000362195 | ENSP00000222139 | colony stimulating factor 3 receptor (granulocyte); Receptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation. Plays a crucial role in the proliferation, differientation and survival of cells along the neutrophilic lineage. In addition it may function in some adhesion or recognition events at the cell surface | erythropoietin receptor; Receptor for erythropoietin. Mediates erythropoietin- induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase | 0.537 |
CSF3R | IL11 | ENSP00000362195 | ENSP00000264563 | colony stimulating factor 3 receptor (granulocyte); Receptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation. Plays a crucial role in the proliferation, differientation and survival of cells along the neutrophilic lineage. In addition it may function in some adhesion or recognition events at the cell surface | interleukin 11; Directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production | 0.817 |
CSF3R | IL6R | ENSP00000362195 | ENSP00000357470 | colony stimulating factor 3 receptor (granulocyte); Receptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation. Plays a crucial role in the proliferation, differientation and survival of cells along the neutrophilic lineage. In addition it may function in some adhesion or recognition events at the cell surface | interleukin 6 receptor; Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis | 0.660 |
CSF3R | JAK1 | ENSP00000362195 | ENSP00000343204 | colony stimulating factor 3 receptor (granulocyte); Receptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation. Plays a crucial role in the proliferation, differientation and survival of cells along the neutrophilic lineage. In addition it may function in some adhesion or recognition events at the cell surface | Janus kinase 1; Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor | 0.940 |
CSF3R | JAK2 | ENSP00000362195 | ENSP00000371067 | colony stimulating factor 3 receptor (granulocyte); Receptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation. Plays a crucial role in the proliferation, differientation and survival of cells along the neutrophilic lineage. In addition it may function in some adhesion or recognition events at the cell surface | Janus kinase 2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors, phosphorylate [...] | 0.952 |
CSF3R | TYK2 | ENSP00000362195 | ENSP00000264818 | colony stimulating factor 3 receptor (granulocyte); Receptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation. Plays a crucial role in the proliferation, differientation and survival of cells along the neutrophilic lineage. In addition it may function in some adhesion or recognition events at the cell surface | tyrosine kinase 2; Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain | 0.854 |
ENSG00000258728 | IL11 | ENSP00000451792 | ENSP00000264563 | Uncharacterized protein | interleukin 11; Directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production | 0.800 |