node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CALM1 | CALM2 | ENSP00000349467 | ENSP00000272298 | calmodulin 1 (phosphorylase kinase, delta) | calmodulin 2 (phosphorylase kinase, delta) | 0.901 |
CALM1 | CALM3 | ENSP00000349467 | ENSP00000291295 | calmodulin 1 (phosphorylase kinase, delta) | calmodulin 3 (phosphorylase kinase, delta) | 0.901 |
CALM2 | CALM1 | ENSP00000272298 | ENSP00000349467 | calmodulin 2 (phosphorylase kinase, delta) | calmodulin 1 (phosphorylase kinase, delta) | 0.901 |
CALM2 | CALM3 | ENSP00000272298 | ENSP00000291295 | calmodulin 2 (phosphorylase kinase, delta) | calmodulin 3 (phosphorylase kinase, delta) | 0.901 |
CALM3 | CALM1 | ENSP00000291295 | ENSP00000349467 | calmodulin 3 (phosphorylase kinase, delta) | calmodulin 1 (phosphorylase kinase, delta) | 0.901 |
CALM3 | CALM2 | ENSP00000291295 | ENSP00000272298 | calmodulin 3 (phosphorylase kinase, delta) | calmodulin 2 (phosphorylase kinase, delta) | 0.901 |
CIAPIN1 | MTRR | ENSP00000377914 | ENSP00000264668 | cytokine induced apoptosis inhibitor 1; May be required for the maturation of extramitochondrial Fe/S proteins (By similarity). Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells (By similarity) | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase; Involved in the reductive regeneration of cob(I)alamin cofactor required for the maintenance of methionine synthase in a functional state | 0.484 |
ENSG00000167807 | MTRR | ENSP00000441093 | ENSP00000264668 | Adrenodoxin-like protein, mitochondrial | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase; Involved in the reductive regeneration of cob(I)alamin cofactor required for the maintenance of methionine synthase in a functional state | 0.538 |
FDX1 | FDX1L | ENSP00000260270 | ENSP00000377311 | ferredoxin 1; Participates in the synthesis of thyroid hormones. Essential for the synthesis of various steroid hormones, participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage | ferredoxin 1-like; Essential for heme A and Fe/S protein biosynthesis | 0.660 |
FDX1 | MTRR | ENSP00000260270 | ENSP00000264668 | ferredoxin 1; Participates in the synthesis of thyroid hormones. Essential for the synthesis of various steroid hormones, participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase; Involved in the reductive regeneration of cob(I)alamin cofactor required for the maintenance of methionine synthase in a functional state | 0.538 |
FDX1L | FDX1 | ENSP00000377311 | ENSP00000260270 | ferredoxin 1-like; Essential for heme A and Fe/S protein biosynthesis | ferredoxin 1; Participates in the synthesis of thyroid hormones. Essential for the synthesis of various steroid hormones, participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage | 0.660 |
FDX1L | MTRR | ENSP00000377311 | ENSP00000264668 | ferredoxin 1-like; Essential for heme A and Fe/S protein biosynthesis | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase; Involved in the reductive regeneration of cob(I)alamin cofactor required for the maintenance of methionine synthase in a functional state | 0.538 |
MMACHC | MMADHC | ENSP00000383840 | ENSP00000301920 | methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria; May be involved in the binding and intracellular trafficking of cobalamin (vitamin B12) | methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria; Involved in cobalamin metabolism | 0.998 |
MMACHC | MTRR | ENSP00000383840 | ENSP00000264668 | methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria; May be involved in the binding and intracellular trafficking of cobalamin (vitamin B12) | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase; Involved in the reductive regeneration of cob(I)alamin cofactor required for the maintenance of methionine synthase in a functional state | 0.948 |
MMADHC | MMACHC | ENSP00000301920 | ENSP00000383840 | methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria; Involved in cobalamin metabolism | methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria; May be involved in the binding and intracellular trafficking of cobalamin (vitamin B12) | 0.998 |
MMADHC | MTRR | ENSP00000301920 | ENSP00000264668 | methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria; Involved in cobalamin metabolism | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase; Involved in the reductive regeneration of cob(I)alamin cofactor required for the maintenance of methionine synthase in a functional state | 0.974 |
MTRR | CIAPIN1 | ENSP00000264668 | ENSP00000377914 | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase; Involved in the reductive regeneration of cob(I)alamin cofactor required for the maintenance of methionine synthase in a functional state | cytokine induced apoptosis inhibitor 1; May be required for the maturation of extramitochondrial Fe/S proteins (By similarity). Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells (By similarity) | 0.484 |
MTRR | ENSG00000167807 | ENSP00000264668 | ENSP00000441093 | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase; Involved in the reductive regeneration of cob(I)alamin cofactor required for the maintenance of methionine synthase in a functional state | Adrenodoxin-like protein, mitochondrial | 0.538 |
MTRR | FDX1 | ENSP00000264668 | ENSP00000260270 | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase; Involved in the reductive regeneration of cob(I)alamin cofactor required for the maintenance of methionine synthase in a functional state | ferredoxin 1; Participates in the synthesis of thyroid hormones. Essential for the synthesis of various steroid hormones, participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage | 0.538 |
MTRR | FDX1L | ENSP00000264668 | ENSP00000377311 | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase; Involved in the reductive regeneration of cob(I)alamin cofactor required for the maintenance of methionine synthase in a functional state | ferredoxin 1-like; Essential for heme A and Fe/S protein biosynthesis | 0.538 |