node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATL1 | UBC | ENSP00000351155 | ENSP00000344818 | atlastin GTPase 1; GTPase tethering membranes through formation of trans- homooligomer and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development | ubiquitin C | 0.620 |
CSNK1A1 | CSNK1E | ENSP00000421689 | ENSP00000352929 | casein kinase 1, alpha 1 | casein kinase 1, epsilon; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2. Retains PER1 in the cytoplasm. Inhibits cytokine-induced granuloytic differentiation | 0.598 |
CSNK1A1 | SNX25 | ENSP00000421689 | ENSP00000264694 | casein kinase 1, alpha 1 | sorting nexin 25; May be involved in several stages of intracellular trafficking (By similarity) | 0.738 |
CSNK1A1 | UBC | ENSP00000421689 | ENSP00000344818 | casein kinase 1, alpha 1 | ubiquitin C | 0.948 |
CSNK1A1 | YWHAZ | ENSP00000421689 | ENSP00000309503 | casein kinase 1, alpha 1 | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide | 0.986 |
CSNK1E | CSNK1A1 | ENSP00000352929 | ENSP00000421689 | casein kinase 1, epsilon; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2. Retains PER1 in the cytoplasm. Inhibits cytokine-induced granuloytic differentiation | casein kinase 1, alpha 1 | 0.598 |
CSNK1E | SNX25 | ENSP00000352929 | ENSP00000264694 | casein kinase 1, epsilon; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2. Retains PER1 in the cytoplasm. Inhibits cytokine-induced granuloytic differentiation | sorting nexin 25; May be involved in several stages of intracellular trafficking (By similarity) | 0.617 |
CSNK1E | UBC | ENSP00000352929 | ENSP00000344818 | casein kinase 1, epsilon; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2. Retains PER1 in the cytoplasm. Inhibits cytokine-induced granuloytic differentiation | ubiquitin C | 0.810 |
CSNK1E | YWHAZ | ENSP00000352929 | ENSP00000309503 | casein kinase 1, epsilon; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2. Retains PER1 in the cytoplasm. Inhibits cytokine-induced granuloytic differentiation | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide | 0.915 |
SEPT2 | UBC | ENSP00000353157 | ENSP00000344818 | septin 2; Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongat [...] | ubiquitin C | 0.901 |
SH3GL3 | UBC | ENSP00000391372 | ENSP00000344818 | SH3-domain GRB2-like 3; Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity) | ubiquitin C | 0.483 |
SIX5 | SNX25 | ENSP00000316842 | ENSP00000264694 | SIX homeobox 5; Transcription factor that is thought to be involved in regulation of organogenesis. May be involved in determination and maintenance of retina formation. Binds a 5’-GGTGTCAG-3’ motif present in the ARE regulatory element of ATP1A1. Binds a 5’- TCA[AG][AG]TTNC-3’ motif present in the MEF3 element in the myogenin promoter, and in the IGFBP5 promoter (By similarity). Thought to be regulated by association with Dach and Eya proteins, and seems to be coactivated by EYA1, EYA2 and EYA3 (By similarity) | sorting nexin 25; May be involved in several stages of intracellular trafficking (By similarity) | 0.644 |
SNX25 | CSNK1A1 | ENSP00000264694 | ENSP00000421689 | sorting nexin 25; May be involved in several stages of intracellular trafficking (By similarity) | casein kinase 1, alpha 1 | 0.738 |
SNX25 | CSNK1E | ENSP00000264694 | ENSP00000352929 | sorting nexin 25; May be involved in several stages of intracellular trafficking (By similarity) | casein kinase 1, epsilon; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2. Retains PER1 in the cytoplasm. Inhibits cytokine-induced granuloytic differentiation | 0.617 |
SNX25 | SIX5 | ENSP00000264694 | ENSP00000316842 | sorting nexin 25; May be involved in several stages of intracellular trafficking (By similarity) | SIX homeobox 5; Transcription factor that is thought to be involved in regulation of organogenesis. May be involved in determination and maintenance of retina formation. Binds a 5’-GGTGTCAG-3’ motif present in the ARE regulatory element of ATP1A1. Binds a 5’- TCA[AG][AG]TTNC-3’ motif present in the MEF3 element in the myogenin promoter, and in the IGFBP5 promoter (By similarity). Thought to be regulated by association with Dach and Eya proteins, and seems to be coactivated by EYA1, EYA2 and EYA3 (By similarity) | 0.644 |
SNX25 | UBC | ENSP00000264694 | ENSP00000344818 | sorting nexin 25; May be involved in several stages of intracellular trafficking (By similarity) | ubiquitin C | 0.483 |
UBC | ATL1 | ENSP00000344818 | ENSP00000351155 | ubiquitin C | atlastin GTPase 1; GTPase tethering membranes through formation of trans- homooligomer and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development | 0.620 |
UBC | CSNK1A1 | ENSP00000344818 | ENSP00000421689 | ubiquitin C | casein kinase 1, alpha 1 | 0.948 |
UBC | CSNK1E | ENSP00000344818 | ENSP00000352929 | ubiquitin C | casein kinase 1, epsilon; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2. Retains PER1 in the cytoplasm. Inhibits cytokine-induced granuloytic differentiation | 0.810 |
UBC | SEPT2 | ENSP00000344818 | ENSP00000353157 | ubiquitin C | septin 2; Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongat [...] | 0.901 |