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DCN | decorin; May affect the rate of fibrils formation (359 aa) | |||
ARSA | arylsulfatase A; Hydrolyzes cerebroside sulfate (509 aa) | |||
STS | steroid sulfatase (microsomal), isozyme S; Conversion of sulfated steroid precursors to estrogens during pregnancy (583 aa) | |||
HYAL4 | hyaluronoglucosaminidase 4; Endo-hyaluronidase that degrades hyaluronan to smaller oligosaccharide fragments. Has also chondroitin sulfate hydrolase activity, The best substrate being the galactosaminidic linkage in the sequence of a trisulfated tetrasaccharide (481 aa) | |||
IDUA | iduronidase, alpha-L- (653 aa) | |||
NCAN | neurocan; May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid (1321 aa) | |||
ARSB | arylsulfatase B (533 aa) | |||
VCAN | versican; May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid (3396 aa) | |||
SUMF1 | sulfatase modifying factor 1 (374 aa) | |||
CSPG4 | chondroitin sulfate proteoglycan 4; Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N- terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma c [...] (2322 aa) | |||
ARSJ | arylsulfatase family, member J (599 aa) | |||
BCAN | brevican; May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans (911 aa) | |||
ARSI | arylsulfatase family, member I; Displays arylsulfatase activity at neutral pH, when co- expressed with SUMF1; arylsulfatase activity is measured in the secretion medium of retinal cell line, but no activity is recorded when measured in cell extracts (569 aa) | |||
SUMF2 | sulfatase modifying factor 2 (358 aa) | |||
SPAM1 | sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding); Involved in sperm-egg adhesion. Upon fertilization sperm must first penetrate a layer of cumulus cells that surrounds the egg before reaching the zona pellucida. The cumulus cells are embedded in a matrix containing hyaluronic acid which is formed prior to ovulation. This protein aids in penetrating the layer of cumulus cells by digesting hyaluronic acid (511 aa) | |||
ARSF | arylsulfatase F (590 aa) | |||
MYC | v-myc myelocytomatosis viral oncogene homolog (avian); Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5’-CAC[GA]TG-3’. Seems to activate the transcription of growth-related genes (454 aa) | |||
ARSK | arylsulfatase family, member K (536 aa) | |||
ARSH | arylsulfatase family, member H (562 aa) | |||
ARSE | arylsulfatase E (chondrodysplasia punctata 1); May be essential for the correct composition of cartilage and bone matrix during development. Has no activity toward steroid sulfates (589 aa) | |||
ARSD | arylsulfatase D (593 aa) | |||
CSPG5 | chondroitin sulfate proteoglycan 5 (neuroglycan C); May function as a growth and differentiation factor involved in neuritogenesis. May induce ERBB3 activation (566 aa) | |||
ELAVL1 | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R); Involved in 3’-UTR ARE-mediated MYC stabilization. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA and AUUUUUA motifs. Binds preferentially to the 5’-UUUU[AG]UUU-3’ motif in vitro (326 aa) |