| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CASP3 | UBC | ENSP00000311032 | ENSP00000344818 | caspase 3, apoptosis-related cysteine peptidase; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a ’216-Asp-|-Gly-217’ bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage | ubiquitin C | 0.920 |
| GPHN | UBC | ENSP00000417901 | ENSP00000344818 | gephyrin; Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released | ubiquitin C | 0.512 |
| SEPT4 | UBC | ENSP00000321674 | ENSP00000344818 | septin 4; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion. Isoform ARTS, but not the other isoforms, is required for the induction of cell death mediated by TGF-beta and by other apoptotic stimuli | ubiquitin C | 0.853 |
| SGK1 | SLC1A3 | ENSP00000356832 | ENSP00000265113 | serum/glucocorticoid regulated kinase 1 | solute carrier family 1 (glial high affinity glutamate transporter), member 3; Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium | 0.800 |
| SGK1 | UBC | ENSP00000356832 | ENSP00000344818 | serum/glucocorticoid regulated kinase 1 | ubiquitin C | 0.999 |
| SLC1A3 | SGK1 | ENSP00000265113 | ENSP00000356832 | solute carrier family 1 (glial high affinity glutamate transporter), member 3; Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium | serum/glucocorticoid regulated kinase 1 | 0.800 |
| SLC1A3 | UBC | ENSP00000265113 | ENSP00000344818 | solute carrier family 1 (glial high affinity glutamate transporter), member 3; Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium | ubiquitin C | 0.864 |
| SLC1A3 | ZDHHC17 | ENSP00000265113 | ENSP00000403397 | solute carrier family 1 (glial high affinity glutamate transporter), member 3; Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium | zinc finger, DHHC-type containing 17; Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HD. Palmitoylates MPP1 in erythrocytes. May be involved in the sorting or targeting of critical proteins involved in the initiating events of endocytosis at the plasma membrane. Has transforming activity. Mediates Mg(2+) transport | 0.442 |
| TNFRSF1B | UBC | ENSP00000365435 | ENSP00000344818 | tumor necrosis factor receptor superfamily, member 1B; Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity | ubiquitin C | 0.835 |
| UBC | CASP3 | ENSP00000344818 | ENSP00000311032 | ubiquitin C | caspase 3, apoptosis-related cysteine peptidase; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a ’216-Asp-|-Gly-217’ bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage | 0.920 |
| UBC | GPHN | ENSP00000344818 | ENSP00000417901 | ubiquitin C | gephyrin; Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released | 0.512 |
| UBC | SEPT4 | ENSP00000344818 | ENSP00000321674 | ubiquitin C | septin 4; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion. Isoform ARTS, but not the other isoforms, is required for the induction of cell death mediated by TGF-beta and by other apoptotic stimuli | 0.853 |
| UBC | SGK1 | ENSP00000344818 | ENSP00000356832 | ubiquitin C | serum/glucocorticoid regulated kinase 1 | 0.999 |
| UBC | SLC1A3 | ENSP00000344818 | ENSP00000265113 | ubiquitin C | solute carrier family 1 (glial high affinity glutamate transporter), member 3; Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium | 0.864 |
| UBC | TNFRSF1B | ENSP00000344818 | ENSP00000365435 | ubiquitin C | tumor necrosis factor receptor superfamily, member 1B; Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity | 0.835 |
| UBC | ZDHHC17 | ENSP00000344818 | ENSP00000403397 | ubiquitin C | zinc finger, DHHC-type containing 17; Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HD. Palmitoylates MPP1 in erythrocytes. May be involved in the sorting or targeting of critical proteins involved in the initiating events of endocytosis at the plasma membrane. Has transforming activity. Mediates Mg(2+) transport | 0.466 |
| ZDHHC17 | SLC1A3 | ENSP00000403397 | ENSP00000265113 | zinc finger, DHHC-type containing 17; Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HD. Palmitoylates MPP1 in erythrocytes. May be involved in the sorting or targeting of critical proteins involved in the initiating events of endocytosis at the plasma membrane. Has transforming activity. Mediates Mg(2+) transport | solute carrier family 1 (glial high affinity glutamate transporter), member 3; Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium | 0.442 |
| ZDHHC17 | UBC | ENSP00000403397 | ENSP00000344818 | zinc finger, DHHC-type containing 17; Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HD. Palmitoylates MPP1 in erythrocytes. May be involved in the sorting or targeting of critical proteins involved in the initiating events of endocytosis at the plasma membrane. Has transforming activity. Mediates Mg(2+) transport | ubiquitin C | 0.466 |
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