amyloid beta (A4) precursor protein-binding, family A, member 1

amyloid beta (A4) precursor-like protein 2; May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5’-GTCACATG-3’(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity)

amyloid beta (A4) precursor protein-binding, family A, member 1

amyloid beta (A4) precursor protein

amyloid beta (A4) precursor protein-binding, family A, member 1

calcium channel, voltage-dependent, N type, alpha 1B subunit; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the ’high-voltage activated’ (HVA) group and are blocked by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin- IIIA (omega-Aga-IIIA). [...]

amyloid beta (A4) precursor protein-binding, family A, member 1

calcium/calmodulin-dependent protein kinase II alpha; CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity)

amyloid beta (A4) precursor protein-binding, family A, member 1

calcium/calmodulin-dependent serine protein kinase (MAGUK family)

amyloid beta (A4) precursor protein-binding, family A, member 1

copper chaperone for superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)

amyloid beta (A4) precursor protein-binding, family A, member 1

contactin associated protein-like 3

amyloid beta (A4) precursor protein-binding, family A, member 1

contactin associated protein-like 4

amyloid beta (A4) precursor protein-binding, family A, member 1

5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system

amyloid beta (A4) precursor protein-binding, family A, member 1

potassium inwardly-rectifying channel, subfamily J, member 12; Inward rectifying potassium channel that is activated by phosphatidylinositol 4,5-bisphosphate and that probably participates in controlling the resting membrane potential in electrically excitable cells. Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracell [...]

amyloid beta (A4) precursor protein-binding, family A, member 1

kinesin family member 17; Transports vesicles containing N-methyl-D-aspartate (NMDA) receptor 2B along microtubules (By similarity)

amyloid beta (A4) precursor protein-binding, family A, member 1

lin-7 homolog B (C. elegans); Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may [...]

amyloid beta (A4) precursor protein-binding, family A, member 1

membrane protein, palmitoylated 1, 55kDa; Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity (By similarity)

amyloid beta (A4) precursor protein-binding, family A, member 1

membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)

amyloid beta (A4) precursor protein-binding, family A, member 1

membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)

amyloid beta (A4) precursor protein-binding, family A, member 1

notch 1; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for normal lymphocyte function. In altered form, may contribute to transformation or progression in some T-cell neoplasms. Involved in the maturation of both CD4+ and CD8+ c [...]

amyloid beta (A4) precursor protein-binding, family A, member 1

neurexin 1; Neuronal cell surface protein that may be involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins. May play a role in formation or maintenance of synaptic junctions. May mediate intracellular signaling. May play a role in angiogenesis (By similarity)

amyloid beta (A4) precursor protein-binding, family A, member 1

presenilin 1; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates cell-cell adhesion though its association with the E-cadherin/catenin complex. Under conditions of apoptosis or calcium influx, cleaves E-cadherin [...]

amyloid beta (A4) precursor protein-binding, family A, member 1

syntaxin 1A (brain)

amyloid beta (A4) precursor protein-binding, family A, member 1

syntaxin binding protein 1; May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1-1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions