node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACTN2 | MYOT | ENSP00000355537 | ENSP00000239926 | actinin, alpha 2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein | myotilin; Component of a complex of multiple actin cross-linking proteins. Involved in the control of myofibril assembly and stability at the Z lines in muscle cells | 0.511 |
ACTN2 | ST7 | ENSP00000355537 | ENSP00000265437 | actinin, alpha 2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein | suppression of tumorigenicity 7 | 0.583 |
ACTN2 | UBC | ENSP00000355537 | ENSP00000344818 | actinin, alpha 2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein | ubiquitin C | 0.872 |
GNB2L1 | ST7 | ENSP00000426909 | ENSP00000265437 | guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 | suppression of tumorigenicity 7 | 0.573 |
GNB2L1 | UBC | ENSP00000426909 | ENSP00000344818 | guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 | ubiquitin C | 0.998 |
MYOT | ACTN2 | ENSP00000239926 | ENSP00000355537 | myotilin; Component of a complex of multiple actin cross-linking proteins. Involved in the control of myofibril assembly and stability at the Z lines in muscle cells | actinin, alpha 2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein | 0.511 |
MYOT | ST7 | ENSP00000239926 | ENSP00000265437 | myotilin; Component of a complex of multiple actin cross-linking proteins. Involved in the control of myofibril assembly and stability at the Z lines in muscle cells | suppression of tumorigenicity 7 | 0.573 |
NFKBIA | UBC | ENSP00000216797 | ENSP00000344818 | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha; Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription | ubiquitin C | 0.999 |
NMRK2 | ST7 | ENSP00000168977 | ENSP00000265437 | nicotinamide riboside kinase 2; Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN). Reduces laminin matrix deposition and cell adhesion to laminin, but not to fibronectin. Involved in the regulation of PXN at the protein level and of PXN tyrosine phosphorylation. May play a role in the regulation of terminal myogenesis | suppression of tumorigenicity 7 | 0.573 |
SNAPIN | ST7 | ENSP00000357674 | ENSP00000265437 | SNAP-associated protein; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking. May modulate a step between vesicle priming, fusion [...] | suppression of tumorigenicity 7 | 0.573 |
SNAPIN | UBC | ENSP00000357674 | ENSP00000344818 | SNAP-associated protein; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking. May modulate a step between vesicle priming, fusion [...] | ubiquitin C | 0.767 |
ST7 | ACTN2 | ENSP00000265437 | ENSP00000355537 | suppression of tumorigenicity 7 | actinin, alpha 2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein | 0.583 |
ST7 | GNB2L1 | ENSP00000265437 | ENSP00000426909 | suppression of tumorigenicity 7 | guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 | 0.573 |
ST7 | MYOT | ENSP00000265437 | ENSP00000239926 | suppression of tumorigenicity 7 | myotilin; Component of a complex of multiple actin cross-linking proteins. Involved in the control of myofibril assembly and stability at the Z lines in muscle cells | 0.573 |
ST7 | NMRK2 | ENSP00000265437 | ENSP00000168977 | suppression of tumorigenicity 7 | nicotinamide riboside kinase 2; Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN). Reduces laminin matrix deposition and cell adhesion to laminin, but not to fibronectin. Involved in the regulation of PXN at the protein level and of PXN tyrosine phosphorylation. May play a role in the regulation of terminal myogenesis | 0.573 |
ST7 | SNAPIN | ENSP00000265437 | ENSP00000357674 | suppression of tumorigenicity 7 | SNAP-associated protein; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking. May modulate a step between vesicle priming, fusion [...] | 0.573 |
ST7 | UBC | ENSP00000265437 | ENSP00000344818 | suppression of tumorigenicity 7 | ubiquitin C | 0.620 |
ST7 | ZFYVE9 | ENSP00000265437 | ENSP00000287727 | suppression of tumorigenicity 7 | zinc finger, FYVE domain containing 9; Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor internalization | 0.587 |
UBC | ACTN2 | ENSP00000344818 | ENSP00000355537 | ubiquitin C | actinin, alpha 2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein | 0.872 |
UBC | GNB2L1 | ENSP00000344818 | ENSP00000426909 | ubiquitin C | guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 | 0.998 |