node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACTB | ACTC1 | ENSP00000349960 | ENSP00000290378 | actin, beta | actin, alpha, cardiac muscle 1; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells | 0.579 |
ACTB | EPB49 | ENSP00000349960 | ENSP00000265800 | actin, beta | erythrocyte membrane protein band 4.9 (dematin); Actin-bundling protein. May function in mitogen- activated protein kinase pathway | 0.576 |
ACTB | GNB2L1 | ENSP00000349960 | ENSP00000426909 | actin, beta | guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 | 0.463 |
ACTB | SNCA | ENSP00000349960 | ENSP00000338345 | actin, beta | synuclein, alpha (non A4 component of amyloid precursor); May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation | 0.629 |
ACTC1 | ACTB | ENSP00000290378 | ENSP00000349960 | actin, alpha, cardiac muscle 1; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells | actin, beta | 0.579 |
ACTC1 | EPB49 | ENSP00000290378 | ENSP00000265800 | actin, alpha, cardiac muscle 1; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells | erythrocyte membrane protein band 4.9 (dematin); Actin-bundling protein. May function in mitogen- activated protein kinase pathway | 0.576 |
EPB42 | EPB49 | ENSP00000300215 | ENSP00000265800 | erythrocyte membrane protein band 4.2; Probably plays an important role in the regulation of erythrocyte shape and mechanical properties | erythrocyte membrane protein band 4.9 (dematin); Actin-bundling protein. May function in mitogen- activated protein kinase pathway | 0.695 |
EPB42 | SPTB | ENSP00000300215 | ENSP00000374372 | erythrocyte membrane protein band 4.2; Probably plays an important role in the regulation of erythrocyte shape and mechanical properties | spectrin, beta, erythrocytic; Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane | 0.681 |
EPB49 | ACTB | ENSP00000265800 | ENSP00000349960 | erythrocyte membrane protein band 4.9 (dematin); Actin-bundling protein. May function in mitogen- activated protein kinase pathway | actin, beta | 0.576 |
EPB49 | ACTC1 | ENSP00000265800 | ENSP00000290378 | erythrocyte membrane protein band 4.9 (dematin); Actin-bundling protein. May function in mitogen- activated protein kinase pathway | actin, alpha, cardiac muscle 1; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells | 0.576 |
EPB49 | EPB42 | ENSP00000265800 | ENSP00000300215 | erythrocyte membrane protein band 4.9 (dematin); Actin-bundling protein. May function in mitogen- activated protein kinase pathway | erythrocyte membrane protein band 4.2; Probably plays an important role in the regulation of erythrocyte shape and mechanical properties | 0.695 |
EPB49 | GNB2L1 | ENSP00000265800 | ENSP00000426909 | erythrocyte membrane protein band 4.9 (dematin); Actin-bundling protein. May function in mitogen- activated protein kinase pathway | guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 | 0.780 |
EPB49 | PRKACA | ENSP00000265800 | ENSP00000309591 | erythrocyte membrane protein band 4.9 (dematin); Actin-bundling protein. May function in mitogen- activated protein kinase pathway | protein kinase, cAMP-dependent, catalytic, alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA, TRPC1 and VASP. RORA is activated by phosphorylation. Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in th [...] | 0.576 |
EPB49 | SNCA | ENSP00000265800 | ENSP00000338345 | erythrocyte membrane protein band 4.9 (dematin); Actin-bundling protein. May function in mitogen- activated protein kinase pathway | synuclein, alpha (non A4 component of amyloid precursor); May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation | 0.573 |
EPB49 | SPTB | ENSP00000265800 | ENSP00000374372 | erythrocyte membrane protein band 4.9 (dematin); Actin-bundling protein. May function in mitogen- activated protein kinase pathway | spectrin, beta, erythrocytic; Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane | 0.740 |
EPB49 | WDR31 | ENSP00000265800 | ENSP00000363308 | erythrocyte membrane protein band 4.9 (dematin); Actin-bundling protein. May function in mitogen- activated protein kinase pathway | WD repeat domain 31 | 0.780 |
GNB2L1 | ACTB | ENSP00000426909 | ENSP00000349960 | guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 | actin, beta | 0.463 |
GNB2L1 | EPB49 | ENSP00000426909 | ENSP00000265800 | guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 | erythrocyte membrane protein band 4.9 (dematin); Actin-bundling protein. May function in mitogen- activated protein kinase pathway | 0.780 |
PRKACA | EPB49 | ENSP00000309591 | ENSP00000265800 | protein kinase, cAMP-dependent, catalytic, alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA, TRPC1 and VASP. RORA is activated by phosphorylation. Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in th [...] | erythrocyte membrane protein band 4.9 (dematin); Actin-bundling protein. May function in mitogen- activated protein kinase pathway | 0.576 |
PRKACA | YWHAB | ENSP00000309591 | ENSP00000300161 | protein kinase, cAMP-dependent, catalytic, alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA, TRPC1 and VASP. RORA is activated by phosphorylation. Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in th [...] | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in bloc [...] | 0.947 |