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STRINGSTRING
LYZL4 LYZL4 IGSF11 IGSF11 BTNL2 BTNL2 BTNL9 BTNL9 DSCAML1 DSCAML1 DSCAM DSCAM CD22 CD22 PVRL4 PVRL4 BTN1A1 BTN1A1 VSIG1 VSIG1 VSIG2 VSIG2 TAPBPL TAPBPL EGFLAM EGFLAM IGSF9B IGSF9B CD276 CD276 BTN3A1 BTN3A1 EYS EYS HSPG2 HSPG2 LYZL1 LYZL1 BTN2A2 BTN2A2 BTN3A3 BTN3A3 BTN2A1 BTN2A1 LYZL2 LYZL2 UBC UBC VEGFA VEGFA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
CD22CD22 molecule (847 aa)
BTN1A1butyrophilin, subfamily 1, member A1; May function in the secretion of milk-fat droplets. May act as a specific membrane-associated receptor for the association of cytoplasmic droplets with the apical plasma membrane (By similarity). Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion (By similarity) (526 aa)
BTN3A3butyrophilin, subfamily 3, member A3; Plays a role in T-cell responses in the adaptive immune response (584 aa)
TAPBPLTAP binding protein-like (468 aa)
LYZL4lysozyme-like 4 (146 aa)
BTN3A1butyrophilin, subfamily 3, member A1 (513 aa)
BTN2A1butyrophilin, subfamily 2, member A1 (527 aa)
DSCAML1Down syndrome cell adhesion molecule like 1; Cell adhesion molecule that plays a role in neuronal self-avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Promotes both isoneuronal self-avoidance for creating an orderly neurite arborization in retinal rod bipolar cells and heteroneuronal self-avoidance to maintain mosaic spacing between AII amacrine cells (By similarity) (2113 aa)
IGSF9Bimmunoglobulin superfamily, member 9B (1349 aa)
VSIG2V-set and immunoglobulin domain containing 2 (327 aa)
CD276CD276 molecule; May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modula [...] (534 aa)
BTNL9butyrophilin-like 9 (535 aa)
UBCubiquitin C (685 aa)
EGFLAMEGF-like, fibronectin type III and laminin G domains (1017 aa)
BTN2A2butyrophilin, subfamily 2, member A2; Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion (By similarity) (523 aa)
PVRL4poliovirus receptor-related 4; Seems to be involved in cell adhesion through trans- homophilic and -heterophilic interactions, the latter including specifically interactions with PVRL2/nectin-1. Does not act as receptor for alpha-herpesvirus entry into cells (510 aa)
VEGFAvascular endothelial growth factor A (412 aa)
HSPG2heparan sulfate proteoglycan 2; Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development (4391 aa)
LYZL2lysozyme-like 2 (194 aa)
LYZL1lysozyme-like 1 (194 aa)
IGSF11immunoglobulin superfamily, member 11; Functions as a cell adhesion molecule through homophilic interaction. Stimulates cell growth (431 aa)
DSCAMDown syndrome cell adhesion molecule; Cell adhesion molecule that plays a role in neuronal self-avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Mediates within retinal amacrine and ganglion cell subtypes both isoneuronal self-avoidance for creating an orderly dendritic arborization and heteroneuronal self-avoidance to maintain the mosaic spacing between amacrine and ganglion cell bodies. Receptor for netrin required for axon guidance independently of and in collaboration with the receptor DCC. In spinal chord devel [...] (2012 aa)
VSIG1V-set and immunoglobulin domain containing 1 (423 aa)
BTNL2butyrophilin-like 2 (MHC class II associated) (482 aa)
EYSeyes shut homolog (Drosophila) (3144 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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