| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AURKB | BIRC5 | ENSP00000463999 | ENSP00000301633 | aurora kinase B | baculoviral IAP repeat containing 5 | 0.999 |
| AURKB | CDCA8 | ENSP00000463999 | ENSP00000316121 | aurora kinase B | cell division cycle associated 8; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment | 0.999 |
| AURKB | GAS2L3 | ENSP00000463999 | ENSP00000266754 | aurora kinase B | growth arrest-specific 2 like 3; Cytoskeletal linker protein. May promote and stabilize the formation of the actin and microtubule network | 0.596 |
| AURKB | KIF20A | ENSP00000463999 | ENSP00000378356 | aurora kinase B | kinesin family member 20A; Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility | 0.996 |
| AURKB | SPAST | ENSP00000463999 | ENSP00000320885 | aurora kinase B | spastin; ATP-dependent microtubule severing protein. Microtubule severing may promote reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Golgi and for completion of the abscission stage of cytokinesis. Also plays a role in axon growth and the formation of axonal branches (By similarity) | 0.654 |
| BIRC5 | AURKB | ENSP00000301633 | ENSP00000463999 | baculoviral IAP repeat containing 5 | aurora kinase B | 0.999 |
| BIRC5 | CDCA8 | ENSP00000301633 | ENSP00000316121 | baculoviral IAP repeat containing 5 | cell division cycle associated 8; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment | 0.999 |
| BIRC5 | ELAVL1 | ENSP00000301633 | ENSP00000385269 | baculoviral IAP repeat containing 5 | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R); Involved in 3’-UTR ARE-mediated MYC stabilization. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA and AUUUUUA motifs. Binds preferentially to the 5’-UUUU[AG]UUU-3’ motif in vitro | 0.504 |
| BIRC5 | GAS2L3 | ENSP00000301633 | ENSP00000266754 | baculoviral IAP repeat containing 5 | growth arrest-specific 2 like 3; Cytoskeletal linker protein. May promote and stabilize the formation of the actin and microtubule network | 0.569 |
| BIRC5 | KIF20A | ENSP00000301633 | ENSP00000378356 | baculoviral IAP repeat containing 5 | kinesin family member 20A; Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility | 0.955 |
| CDCA8 | AURKB | ENSP00000316121 | ENSP00000463999 | cell division cycle associated 8; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment | aurora kinase B | 0.999 |
| CDCA8 | BIRC5 | ENSP00000316121 | ENSP00000301633 | cell division cycle associated 8; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment | baculoviral IAP repeat containing 5 | 0.999 |
| CDCA8 | GAS2L3 | ENSP00000316121 | ENSP00000266754 | cell division cycle associated 8; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment | growth arrest-specific 2 like 3; Cytoskeletal linker protein. May promote and stabilize the formation of the actin and microtubule network | 0.605 |
| CDCA8 | KIF20A | ENSP00000316121 | ENSP00000378356 | cell division cycle associated 8; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment | kinesin family member 20A; Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility | 0.955 |
| ELAVL1 | BIRC5 | ENSP00000385269 | ENSP00000301633 | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R); Involved in 3’-UTR ARE-mediated MYC stabilization. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA and AUUUUUA motifs. Binds preferentially to the 5’-UUUU[AG]UUU-3’ motif in vitro | baculoviral IAP repeat containing 5 | 0.504 |
| ELAVL1 | SPAST | ENSP00000385269 | ENSP00000320885 | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R); Involved in 3’-UTR ARE-mediated MYC stabilization. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA and AUUUUUA motifs. Binds preferentially to the 5’-UUUU[AG]UUU-3’ motif in vitro | spastin; ATP-dependent microtubule severing protein. Microtubule severing may promote reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Golgi and for completion of the abscission stage of cytokinesis. Also plays a role in axon growth and the formation of axonal branches (By similarity) | 0.463 |
| GAS2L3 | AURKB | ENSP00000266754 | ENSP00000463999 | growth arrest-specific 2 like 3; Cytoskeletal linker protein. May promote and stabilize the formation of the actin and microtubule network | aurora kinase B | 0.596 |
| GAS2L3 | BIRC5 | ENSP00000266754 | ENSP00000301633 | growth arrest-specific 2 like 3; Cytoskeletal linker protein. May promote and stabilize the formation of the actin and microtubule network | baculoviral IAP repeat containing 5 | 0.569 |
| GAS2L3 | CDCA8 | ENSP00000266754 | ENSP00000316121 | growth arrest-specific 2 like 3; Cytoskeletal linker protein. May promote and stabilize the formation of the actin and microtubule network | cell division cycle associated 8; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment | 0.605 |
| GAS2L3 | KIF20A | ENSP00000266754 | ENSP00000378356 | growth arrest-specific 2 like 3; Cytoskeletal linker protein. May promote and stabilize the formation of the actin and microtubule network | kinesin family member 20A; Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility | 0.569 |
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