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PDE2A PDE2A PDE1A PDE1A PDE4B PDE4B PDE4D PDE4D RRM1 RRM1 PKM PKM NTPCR NTPCR AK7 AK7 DCK DCK RRM2 RRM2 AMPD3 AMPD3 NT5M NT5M ENTPD8 ENTPD8 ENTPD2 ENTPD2 ENTPD1 ENTPD1 APRT APRT NT5C2 NT5C2 ENTPD3 ENTPD3 NME2 NME2 NME7 NME7 PDE8A PDE8A PDE4C PDE4C NME1-NME2 NME1-NME2 PDE1C PDE1C PDE7B PDE7B PDE3A PDE3A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
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colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
AK7adenylate kinase 7; Adenylate kinase involved in maintaining ciliary structure and function (By similarity). Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP (723 aa)
DCKdeoxycytidine kinase; Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents (260 aa)
RRM1ribonucleotide reductase M1; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) (792 aa)
ENTPD3ectonucleoside triphosphate diphosphohydrolase 3; Has a threefold preference for the hydrolysis of ATP over ADP (529 aa)
PDE7Bphosphodiesterase 7B; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in the control of cAMP-mediated neural activity and cAMP metabolism in the brain (450 aa)
PDE8Aphosphodiesterase 8A (829 aa)
PKMpyruvate kinase, muscle (531 aa)
PDE1Aphosphodiesterase 1A, calmodulin-dependent (545 aa)
PDE4Bphosphodiesterase 4B, cAMP-specific; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents (736 aa)
PDE2Aphosphodiesterase 2A, cGMP-stimulated; Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (941 aa)
NT5C25’-nucleotidase, cytosolic II; May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5’-monophosphate (IMP) and other purine nucleotides (561 aa)
PDE4Dphosphodiesterase 4D, cAMP-specific (809 aa)
ENTPD2ectonucleoside triphosphate diphosphohydrolase 2; In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Hydrolyzes ADP only to a marginal extent. The order of activity with different substrates is ATP > GTP > CTP = ITP > UTP >> ADP = UDP (495 aa)
PDE4Cphosphodiesterase 4C, cAMP-specific; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (712 aa)
PDE3Aphosphodiesterase 3A, cGMP-inhibited; Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (By similarity) (1141 aa)
RRM2ribonucleotide reductase M2; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling (449 aa)
NTPCRnucleoside-triphosphatase, cancer-related; Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. Hydrolyzes nucleoside diphosphates with lower efficiency (190 aa)
NME7NME/NM23 family member 7; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (376 aa)
ENTPD1ectonucleoside triphosphate diphosphohydrolase 1 (522 aa)
ENTPD8ectonucleoside triphosphate diphosphohydrolase 8; Canalicular ectonucleoside NTPDase responsible for the main hepatic NTPDase activity. Ectonucleoside NTPDases catalyze the hydrolysis of gamma- and beta-phosphate residues of nucleotides, playing a central role in concentration of extracellular nucleotides. Has activity toward ATP, ADP, UTP and UDP, but not toward AMP (495 aa)
APRTadenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (180 aa)
NT5M5’,3’-nucleotidase, mitochondrial; Dephosphorylates specifically the 5’ and 2’(3’)- phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP (228 aa)
NME1-NME2NME1-NME2 readthrough; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) (152 aa)
NME2NME/NM23 nucleoside diphosphate kinase 2; Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed-8392752). Exhibits histidine protein kinase activity (267 aa)
PDE1Cphosphodiesterase 1C, calmodulin-dependent 70kDa; Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a high affinity for both cAMP and cGMP (769 aa)
AMPD3adenosine monophosphate deaminase 3; AMP deaminase plays a critical role in energy metabolism (776 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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