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EMC9 | ER membrane protein complex subunit 9 (208 aa) | |||
EMC2 | ER membrane protein complex subunit 2 (297 aa) | |||
OAS3 | 2’-5’-oligoadenylate synthetase 3, 100kDa; Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2’-5’- oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in [...] (1087 aa) | |||
SEC61A1 | Sec61 alpha 1 subunit (S. cerevisiae) (476 aa) | |||
EMC3 | ER membrane protein complex subunit 3 (261 aa) | |||
EMC6 | ER membrane protein complex subunit 6 (110 aa) | |||
EMC8 | ER membrane protein complex subunit 8 (210 aa) | |||
EMC7 | ER membrane protein complex subunit 7 (242 aa) | |||
OASL | 2’-5’-oligoadenylate synthetase-like; Does not have 2’-5’-OAS activity, but can bind double- stranded RNA. Displays antiviral activity against encephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) via an alternative antiviral pathway independent of RNase L (514 aa) | |||
EMC4 | ER membrane protein complex subunit 4; May mediate anti-apoptotic activity (183 aa) | |||
SEC61A2 | Sec61 alpha 2 subunit (S. cerevisiae); Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins. Found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins (By similarity) (476 aa) | |||
UBB | ubiquitin B (229 aa) | |||
MMGT1 | membrane magnesium transporter 1; Mediates Mg(2+) transport (By similarity) (131 aa) | |||
ENSG00000173727 | Uncharacterized protein (112 aa) | |||
EMC10 | ER membrane protein complex subunit 10 (262 aa) | |||
UBL4B | ubiquitin-like 4B (174 aa) | |||
UBE2G2 | ubiquitin-conjugating enzyme E2G 2; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes ’Lys- 48’-linked polyubiquitination. Involved in endoplasmic reticulum- associated degradation (ERAD) (165 aa) | |||
OAS2 | 2’-5’-oligoadenylate synthetase 2, 69/71kDa; Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2’-5’-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the [...] (719 aa) | |||
UBC | ubiquitin C (685 aa) | |||
UBL4A | ubiquitin-like 4A; Component of the BAT3 complex, a multiprotein complex involved in the post-translational delivery of tail-anchored (TA) membrane proteins to the endoplasmic reticulum membrane. TA membrane proteins, also named type II transmembrane proteins, contain a single C-terminal transmembrane region. The complex acts by facilitating TA proteins capture by ASNA1/TRC40- it is recruited to ribosomes synthesizing membrane proteins, interacts with the transmembrane region of newly released TA proteins, and transfers them to ASNA1/TRC40 for targeting (157 aa) | |||
UBD | ubiquitin D (165 aa) | |||
VPS28 | vacuolar protein sorting 28 homolog (S. cerevisiae); Component of the ESCRT-I complex, a regulator of vesicular trafficking process (233 aa) | |||
OAS1 | 2’-5’-oligoadenylate synthetase 1, 40/46kDa (414 aa) | |||
EMC1 | ER membrane protein complex subunit 1 (993 aa) | |||
FAU | Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (133 aa) | |||
UBBP4 | ubiquitin B pseudogene 4 (229 aa) |