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VPS28 VPS28 UBL4B UBL4B ENSG00000173727 ENSG00000173727 SEC61A1 SEC61A1 SEC61A2 SEC61A2 UBBP4 UBBP4 EMC4 EMC4 UBB UBB EMC3 EMC3 UBE2G2 UBE2G2 UBD UBD EMC2 EMC2 EMC9 EMC9 UBC UBC FAU FAU EMC1 EMC1 MMGT1 MMGT1 EMC8 EMC8 EMC10 EMC10 EMC7 EMC7 EMC6 EMC6 OASL OASL UBL4A UBL4A OAS2 OAS2 OAS1 OAS1 OAS3 OAS3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
EMC9ER membrane protein complex subunit 9 (208 aa)
EMC2ER membrane protein complex subunit 2 (297 aa)
OAS32’-5’-oligoadenylate synthetase 3, 100kDa; Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2’-5’- oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in [...] (1087 aa)
SEC61A1Sec61 alpha 1 subunit (S. cerevisiae) (476 aa)
EMC3ER membrane protein complex subunit 3 (261 aa)
EMC6ER membrane protein complex subunit 6 (110 aa)
EMC8ER membrane protein complex subunit 8 (210 aa)
EMC7ER membrane protein complex subunit 7 (242 aa)
OASL2’-5’-oligoadenylate synthetase-like; Does not have 2’-5’-OAS activity, but can bind double- stranded RNA. Displays antiviral activity against encephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) via an alternative antiviral pathway independent of RNase L (514 aa)
EMC4ER membrane protein complex subunit 4; May mediate anti-apoptotic activity (183 aa)
SEC61A2Sec61 alpha 2 subunit (S. cerevisiae); Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins. Found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins (By similarity) (476 aa)
UBBubiquitin B (229 aa)
MMGT1membrane magnesium transporter 1; Mediates Mg(2+) transport (By similarity) (131 aa)
ENSG00000173727Uncharacterized protein (112 aa)
EMC10ER membrane protein complex subunit 10 (262 aa)
UBL4Bubiquitin-like 4B (174 aa)
UBE2G2ubiquitin-conjugating enzyme E2G 2; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes ’Lys- 48’-linked polyubiquitination. Involved in endoplasmic reticulum- associated degradation (ERAD) (165 aa)
OAS22’-5’-oligoadenylate synthetase 2, 69/71kDa; Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2’-5’-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the [...] (719 aa)
UBCubiquitin C (685 aa)
UBL4Aubiquitin-like 4A; Component of the BAT3 complex, a multiprotein complex involved in the post-translational delivery of tail-anchored (TA) membrane proteins to the endoplasmic reticulum membrane. TA membrane proteins, also named type II transmembrane proteins, contain a single C-terminal transmembrane region. The complex acts by facilitating TA proteins capture by ASNA1/TRC40- it is recruited to ribosomes synthesizing membrane proteins, interacts with the transmembrane region of newly released TA proteins, and transfers them to ASNA1/TRC40 for targeting (157 aa)
UBDubiquitin D (165 aa)
VPS28vacuolar protein sorting 28 homolog (S. cerevisiae); Component of the ESCRT-I complex, a regulator of vesicular trafficking process (233 aa)
OAS12’-5’-oligoadenylate synthetase 1, 40/46kDa (414 aa)
EMC1ER membrane protein complex subunit 1 (993 aa)
FAUFinkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (133 aa)
UBBP4ubiquitin B pseudogene 4 (229 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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