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ATP5L2 ATP5L2 SLC30A10 SLC30A10 SLC30A1 SLC30A1 JAGN1 JAGN1 ATP1A3 ATP1A3 ATP1A4 ATP1A4 TECR TECR ATP1A1 ATP1A1 ATP1A2 ATP1A2 ABCA3 ABCA3 ATP12A ATP12A UBC UBC TECRL TECRL ATP4A ATP4A EPS15 EPS15 PLD1 PLD1 SLC9A7 SLC9A7 PLD2 PLD2 SCAMP2 SCAMP2 RAB4A RAB4A RAB4B RAB4B SNAP23 SNAP23
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
TECRtrans-2,3-enoyl-CoA reductase; Reduces trans-2,3-stearoyl-CoA to stearoyl-CoA of long and very long chain fatty acids (308 aa)
ATP12AATPase, H+/K+ transporting, nongastric, alpha polypeptide; Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for potassium absorption in various tissues (1045 aa)
SNAP23synaptosomal-associated protein, 23kDa; Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion (211 aa)
ATP4AATPase, H+/K+ exchanging, alpha polypeptide; Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for acid production in the stomach (1035 aa)
PLD2phospholipase D2; May have a role in signal-induced cytoskeletal regulation and/or endocytosis (By similarity) (933 aa)
SCAMP2secretory carrier membrane protein 2; Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface (329 aa)
ATP1A1ATPase, Na+/K+ transporting, alpha 1 polypeptide; This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients (1023 aa)
ABCA3ATP-binding cassette, sub-family A (ABC1), member 3; Plays an important role in the formation of pulmonary surfactant, probably by transporting lipids such as cholesterol (1704 aa)
ATP1A3ATPase, Na+/K+ transporting, alpha 3 polypeptide; This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients (1013 aa)
JAGN1jagunal homolog 1 (Drosophila); May be required for endoplasmic reticulum organization (By similarity) (183 aa)
SLC9A7solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7; Mediates electroneutral exchange of protons for Na(+) and K(+) across endomembranes. May contribute to Golgi volume and cation homeostasis (725 aa)
PLD1phospholipase D1, phosphatidylcholine-specific; Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity) (1074 aa)
UBCubiquitin C (685 aa)
RAB4BRAB4B, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) (213 aa)
ATP1A2ATPase, Na+/K+ transporting, alpha 2 polypeptide; This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients (1020 aa)
RAB4ARAB4A, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) (218 aa)
SLC30A10solute carrier family 30, member 10; May be involved in zinc transport out of the cell, being a zinc-efflux transporter (By similarity) (485 aa)
SLC30A1solute carrier family 30 (zinc transporter), member 1; May be involved in zinc transport out of the cell (507 aa)
ATP1A4ATPase, Na+/K+ transporting, alpha 4 polypeptide; This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Plays a role in sperm motility (1029 aa)
EPS15epidermal growth factor receptor pathway substrate 15; Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta- 1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seem [...] (896 aa)
TECRLtrans-2,3-enoyl-CoA reductase-like (363 aa)
ATP5L2ATP synthase, H+ transporting, mitochondrial Fo complex, subunit G2; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via [...] (100 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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