node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CDC40 | CRNKL1 | ENSP00000304370 | ENSP00000366557 | cell division cycle 40 homolog (S. cerevisiae); Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing | crooked neck pre-mRNA splicing factor-like 1 (Drosophila) | 0.984 |
CDC40 | DHX8 | ENSP00000304370 | ENSP00000262415 | cell division cycle 40 homolog (S. cerevisiae); Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing | DEAH (Asp-Glu-Ala-His) box polypeptide 8; Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome | 0.989 |
CDC40 | EFTUD1 | ENSP00000304370 | ENSP00000268206 | cell division cycle 40 homolog (S. cerevisiae); Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing | elongation factor Tu GTP binding domain containing 1; Involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with SBDS, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Has low intrinsic GTPase activity. GTPase activity is increased by contact with 60S ribosome subunits | 0.561 |
CDC40 | PRPF8 | ENSP00000304370 | ENSP00000304350 | cell division cycle 40 homolog (S. cerevisiae); Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing | PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae); Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5’ and the 3’ splice site | 0.996 |
CDC40 | SNW1 | ENSP00000304370 | ENSP00000261531 | cell division cycle 40 homolog (S. cerevisiae); Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing | SNW domain containing 1; Involved in transcriptional regulation. Modulates TGF- beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1- mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coactivators [...] | 0.962 |
CDC40 | XAB2 | ENSP00000304370 | ENSP00000351137 | cell division cycle 40 homolog (S. cerevisiae); Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing | XPA binding protein 2; Involved in transcription-coupled repair (TCR), transcription and pre-mRNA splicing | 0.983 |
CRNKL1 | CDC40 | ENSP00000366557 | ENSP00000304370 | crooked neck pre-mRNA splicing factor-like 1 (Drosophila) | cell division cycle 40 homolog (S. cerevisiae); Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing | 0.984 |
CRNKL1 | DHX8 | ENSP00000366557 | ENSP00000262415 | crooked neck pre-mRNA splicing factor-like 1 (Drosophila) | DEAH (Asp-Glu-Ala-His) box polypeptide 8; Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome | 0.980 |
CRNKL1 | EFTUD1 | ENSP00000366557 | ENSP00000268206 | crooked neck pre-mRNA splicing factor-like 1 (Drosophila) | elongation factor Tu GTP binding domain containing 1; Involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with SBDS, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Has low intrinsic GTPase activity. GTPase activity is increased by contact with 60S ribosome subunits | 0.592 |
CRNKL1 | PRPF8 | ENSP00000366557 | ENSP00000304350 | crooked neck pre-mRNA splicing factor-like 1 (Drosophila) | PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae); Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5’ and the 3’ splice site | 0.989 |
CRNKL1 | SNW1 | ENSP00000366557 | ENSP00000261531 | crooked neck pre-mRNA splicing factor-like 1 (Drosophila) | SNW domain containing 1; Involved in transcriptional regulation. Modulates TGF- beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1- mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coactivators [...] | 0.983 |
CRNKL1 | XAB2 | ENSP00000366557 | ENSP00000351137 | crooked neck pre-mRNA splicing factor-like 1 (Drosophila) | XPA binding protein 2; Involved in transcription-coupled repair (TCR), transcription and pre-mRNA splicing | 0.982 |
DHX8 | CDC40 | ENSP00000262415 | ENSP00000304370 | DEAH (Asp-Glu-Ala-His) box polypeptide 8; Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome | cell division cycle 40 homolog (S. cerevisiae); Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing | 0.989 |
DHX8 | CRNKL1 | ENSP00000262415 | ENSP00000366557 | DEAH (Asp-Glu-Ala-His) box polypeptide 8; Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome | crooked neck pre-mRNA splicing factor-like 1 (Drosophila) | 0.980 |
DHX8 | EFTUD1 | ENSP00000262415 | ENSP00000268206 | DEAH (Asp-Glu-Ala-His) box polypeptide 8; Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome | elongation factor Tu GTP binding domain containing 1; Involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with SBDS, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Has low intrinsic GTPase activity. GTPase activity is increased by contact with 60S ribosome subunits | 0.862 |
DHX8 | MRPS6 | ENSP00000262415 | ENSP00000382250 | DEAH (Asp-Glu-Ala-His) box polypeptide 8; Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome | mitochondrial ribosomal protein S6 | 0.491 |
DHX8 | PRPF8 | ENSP00000262415 | ENSP00000304350 | DEAH (Asp-Glu-Ala-His) box polypeptide 8; Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome | PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae); Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5’ and the 3’ splice site | 0.947 |
DHX8 | RPL5 | ENSP00000262415 | ENSP00000359345 | DEAH (Asp-Glu-Ala-His) box polypeptide 8; Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome | ribosomal protein L5; Required for rRNA maturation and formation of the 60S ribosomal subunits. This protein binds 5S RNA | 0.571 |
DHX8 | RPS15A | ENSP00000262415 | ENSP00000318646 | DEAH (Asp-Glu-Ala-His) box polypeptide 8; Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome | ribosomal protein S15a | 0.546 |
DHX8 | RPS3 | ENSP00000262415 | ENSP00000433821 | DEAH (Asp-Glu-Ala-His) box polypeptide 8; Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome | ribosomal protein S3 | 0.435 |